ENSG00000008405

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000008527 ENSG00000008405 HEK293_OSMI2_6hA HEK293_TMG_6hB CRY1 protein_coding protein_coding 15.43492 8.140287 26.56236 0.8612897 0.7113202 1.705004 12.2016829 7.0439946 18.866540 0.9951655 0.2945434 1.420082 0.81129167 0.8583333 0.71070000 -0.14763333 9.798504e-02 1.030874e-08 FALSE  
ENST00000546722 ENSG00000008405 HEK293_OSMI2_6hA HEK293_TMG_6hB CRY1 protein_coding retained_intron 15.43492 8.140287 26.56236 0.8612897 0.7113202 1.705004 1.6601047 0.7776464 4.103919 0.0736138 0.2552607 2.384893 0.10063750 0.0990000 0.15420000 0.05520000 3.911314e-01 1.030874e-08 FALSE  
ENST00000549356 ENSG00000008405 HEK293_OSMI2_6hA HEK293_TMG_6hB CRY1 protein_coding protein_coding 15.43492 8.140287 26.56236 0.8612897 0.7113202 1.705004 0.5050912 0.0000000 1.435690 0.0000000 0.1174363 7.175614 0.02354583 0.0000000 0.05386667 0.05386667 1.030874e-08 1.030874e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000008405 E001 0.7982606 0.0170375576 0.0212762847   12 106991364 106991366 3 - 0.081 0.481 3.306
ENSG00000008405 E002 77.1442486 0.0206132814 0.1536503663 0.367517376 12 106991367 106991610 244 - 1.809 1.938 0.436
ENSG00000008405 E003 190.2439435 0.0077714499 0.0009080564 0.009161104 12 106991611 106992001 391 - 2.185 2.349 0.550
ENSG00000008405 E004 19.3532303 0.0787011899 0.4564350753 0.670619278 12 106992002 106992486 485 - 1.293 1.211 -0.288
ENSG00000008405 E005 14.2890873 0.0432649477 0.0045442134 0.032170750 12 106992487 106992786 300 - 1.231 0.820 -1.512
ENSG00000008405 E006 126.2748728 0.0013127921 0.7184097688 0.847244881 12 106992787 106992890 104 - 2.054 2.080 0.088
ENSG00000008405 E007 15.1913860 0.0672695744 0.5538149534 0.738955151 12 106992891 106992964 74 - 1.191 1.122 -0.247
ENSG00000008405 E008 123.8852049 0.0005495397 0.5308241225 0.722631766 12 106992965 106993036 72 - 2.057 2.050 -0.026
ENSG00000008405 E009 111.8036146 0.0003644065 0.9476538068 0.976146764 12 106997294 106997386 93 - 2.008 2.025 0.057
ENSG00000008405 E010 0.1723744 0.0332179765 0.1983913305   12 106997387 106997406 20 - 0.000 0.178 10.531
ENSG00000008405 E011 141.3862770 0.0024766045 0.0764115867 0.237550706 12 106997488 106997690 203 - 2.091 2.171 0.271
ENSG00000008405 E012 128.5477160 0.0056883431 0.7333180774 0.856251710 12 106997915 106998066 152 - 2.075 2.069 -0.019
ENSG00000008405 E013 200.1436001 0.0005751955 0.1353444831 0.340300941 12 106999551 106999788 238 - 2.272 2.244 -0.092
ENSG00000008405 E014 105.0953216 0.0063319930 0.3318702873 0.570699162 12 106999789 106999862 74 - 1.995 1.955 -0.135
ENSG00000008405 E015 17.3796618 0.0355760634 0.1334856697 0.337265107 12 106999863 106999941 79 - 1.267 1.070 -0.701
ENSG00000008405 E016 140.1028332 0.0035564733 0.5125475632 0.709889285 12 106999942 107000082 141 - 2.113 2.100 -0.043
ENSG00000008405 E017 101.3305325 0.0043336761 0.4797163841 0.686923393 12 107001280 107001368 89 - 1.979 1.962 -0.060
ENSG00000008405 E018 158.5912337 0.0003164919 0.0324971136 0.134702400 12 107001764 107001948 185 - 2.179 2.128 -0.169
ENSG00000008405 E019 117.9511186 0.0007745789 0.2772744923 0.517303885 12 107005106 107005248 143 - 2.042 2.017 -0.085
ENSG00000008405 E020 87.2886096 0.0004359880 0.0047094300 0.033059256 12 107022084 107022192 109 - 1.934 1.829 -0.354
ENSG00000008405 E021 0.1614157 0.0327860102 1.0000000000   12 107042950 107043178 229 - 0.081 0.000 -7.951
ENSG00000008405 E022 1.2956455 0.0136968632 0.2624656459   12 107049771 107049852 82 - 0.387 0.178 -1.500
ENSG00000008405 E023 0.0000000       12 107049954 107050359 406 -      
ENSG00000008405 E024 3.5492023 0.0083112424 0.0219583669 0.102440126 12 107072935 107073054 120 - 0.708 0.304 -2.017
ENSG00000008405 E025 166.6071516 0.0066957136 0.1810464509 0.405323992 12 107092804 107093549 746 - 2.163 2.238 0.249