ENSG00000008394

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396210 ENSG00000008394 HEK293_OSMI2_6hA HEK293_TMG_6hB MGST1 protein_coding protein_coding 20.00737 17.60975 17.81736 3.259982 0.3165003 0.01689899 18.1777512 15.498695 16.1603606 2.9849564 0.34002681 0.06027458 0.90621250 0.87680000 0.90693333 0.03013333 0.595870784 0.002295083 FALSE  
ENST00000543076 ENSG00000008394 HEK293_OSMI2_6hA HEK293_TMG_6hB MGST1 protein_coding protein_coding 20.00737 17.60975 17.81736 3.259982 0.3165003 0.01689899 0.6676585 1.172904 0.2238214 0.3872754 0.03594553 -2.33885393 0.03123333 0.06306667 0.01263333 -0.05043333 0.002295083 0.002295083 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000008394 E001 0.0000000       12 16347142 16347184 43 +      
ENSG00000008394 E002 1.3274104 0.0132086488 0.4155167724   12 16347645 16347651 7 + 0.423 0.289 -0.800
ENSG00000008394 E003 1.3274104 0.0132086488 0.4155167724   12 16347652 16347653 2 + 0.423 0.289 -0.800
ENSG00000008394 E004 6.6691050 0.0252324735 0.3577018615 0.59390127 12 16347654 16347663 10 + 0.799 0.935 0.526
ENSG00000008394 E005 32.8546568 0.0013090758 0.5622989814 0.74491423 12 16347664 16347693 30 + 1.535 1.517 -0.061
ENSG00000008394 E006 40.2372201 0.0013107363 0.1464967251 0.35717279 12 16347694 16347710 17 + 1.645 1.583 -0.212
ENSG00000008394 E007 0.4820342 0.0213671224 0.0736298794   12 16347778 16347796 19 + 0.299 0.000 -12.660
ENSG00000008394 E008 1.4708529 0.0120438673 0.0103576034 0.05966417 12 16347797 16347898 102 + 0.561 0.119 -3.061
ENSG00000008394 E009 0.0000000       12 16348894 16349106 213 +      
ENSG00000008394 E010 0.1426347 0.0320621001 0.4597155697   12 16350746 16350799 54 + 0.124 0.000 -11.035
ENSG00000008394 E011 0.0000000       12 16353417 16353467 51 +      
ENSG00000008394 E012 60.6231665 0.0010073980 0.1034986515 0.28803556 12 16354231 16354270 40 + 1.817 1.762 -0.185
ENSG00000008394 E013 95.1510128 0.0005749566 0.0002153546 0.00284564 12 16354271 16354378 108 + 2.039 1.931 -0.365
ENSG00000008394 E014 0.6370325 0.0842281693 0.3631030683   12 16354379 16354724 346 + 0.124 0.289 1.520
ENSG00000008394 E015 0.7984482 0.2672624572 0.7132258980   12 16357511 16357604 94 + 0.220 0.289 0.513
ENSG00000008394 E016 124.8365197 0.0005237524 0.7681775804 0.87754592 12 16357605 16357699 95 + 2.089 2.114 0.085
ENSG00000008394 E017 0.0000000       12 16360300 16360443 144 +      
ENSG00000008394 E018 2.1970892 0.0119341158 0.0147649797 0.07719687 12 16362568 16363794 1227 + 0.220 0.651 2.401
ENSG00000008394 E019 257.6191582 0.0036641113 0.0028257773 0.02234608 12 16363795 16364410 616 + 2.363 2.454 0.304
ENSG00000008394 E020 0.9596762 0.0165805439 0.4767759399   12 16367325 16367465 141 + 0.220 0.354 0.936
ENSG00000008394 E021 0.6966548 0.0937246214 0.7862204002   12 16369769 16370408 640 + 0.219 0.286 0.500
ENSG00000008394 E022 0.4536995 0.1702727635 0.5592947251   12 16376122 16377192 1071 + 0.220 0.118 -1.082
ENSG00000008394 E023 0.1723744 0.0485011520 0.5166690668   12 16382827 16383506 680 + 0.000 0.119 9.970
ENSG00000008394 E024 0.6238610 0.0200439615 0.9346888557   12 16383507 16383604 98 + 0.220 0.212 -0.064
ENSG00000008394 E025 0.0000000       12 16437388 16438761 1374 +      
ENSG00000008394 E026 0.0000000       12 16589528 16589580 53 +      
ENSG00000008394 E027 0.0000000       12 16609094 16609259 166 +