ENSG00000008311

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000417368 ENSG00000008311 HEK293_OSMI2_6hA HEK293_TMG_6hB AASS protein_coding protein_coding 9.659746 4.881998 16.59372 0.7152261 0.5529469 1.763011 6.7736883 2.429879 13.26008 0.5439195 0.5089617 2.443295 0.6212875 0.4859000 0.7988667 0.3129667 5.047291e-06 2.331663e-28 FALSE TRUE
ENST00000681213 ENSG00000008311 HEK293_OSMI2_6hA HEK293_TMG_6hB AASS protein_coding protein_coding 9.659746 4.881998 16.59372 0.7152261 0.5529469 1.763011 0.5352777 1.822106 0.00000 0.3421897 0.0000000 -7.517360 0.1474417 0.3685667 0.0000000 -0.3685667 2.331663e-28 2.331663e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000008311 E001 0.0000000       7 122064583 122064650 68 -      
ENSG00000008311 E002 2.0043565 0.0114866347 1.731265e-01 3.946742e-01 7 122073549 122073564 16 - 0.352 0.594 1.230
ENSG00000008311 E003 3.2361305 0.0081560716 1.110501e-01 3.006834e-01 7 122073565 122073582 18 - 0.497 0.754 1.130
ENSG00000008311 E004 3.0333963 0.0081475439 2.061053e-01 4.371352e-01 7 122073583 122073586 4 - 0.497 0.707 0.936
ENSG00000008311 E005 277.9531069 0.0002486477 1.749618e-21 6.088633e-19 7 122073587 122074494 908 - 2.316 2.537 0.735
ENSG00000008311 E006 158.1917512 0.0034440303 3.486651e-02 1.412645e-01 7 122074495 122074895 401 - 2.111 2.203 0.309
ENSG00000008311 E007 59.9493674 0.0106337772 1.480942e-01 3.596117e-01 7 122074896 122074973 78 - 1.690 1.794 0.354
ENSG00000008311 E008 208.1419809 0.0050406334 4.880058e-01 6.926644e-01 7 122074974 122075646 673 - 2.245 2.274 0.099
ENSG00000008311 E009 90.5077888 0.0147982434 4.929006e-01 6.958859e-01 7 122075647 122076132 486 - 1.881 1.934 0.179
ENSG00000008311 E010 17.2854540 0.0098578717 7.888349e-01 8.897998e-01 7 122076133 122076148 16 - 1.189 1.223 0.120
ENSG00000008311 E011 34.2603484 0.0529357271 8.375464e-01 9.180624e-01 7 122076149 122076244 96 - 1.470 1.521 0.173
ENSG00000008311 E012 36.1127788 0.0134818138 5.685036e-01 7.491439e-01 7 122076245 122076302 58 - 1.494 1.552 0.199
ENSG00000008311 E013 116.8534397 0.0024084037 5.055407e-01 7.046557e-01 7 122076303 122076607 305 - 1.998 2.032 0.111
ENSG00000008311 E014 0.7804750 0.0223140246 8.829772e-01   7 122077836 122077837 2 - 0.233 0.200 -0.284
ENSG00000008311 E015 121.4082456 0.0013443914 9.426014e-01 9.735825e-01 7 122077838 122078014 177 - 2.021 2.030 0.028
ENSG00000008311 E016 3.7145232 0.3388021204 7.250682e-01 8.511642e-01 7 122078015 122078861 847 - 0.564 0.760 0.836
ENSG00000008311 E017 80.0152816 0.0009731238 5.739650e-01 7.529970e-01 7 122078862 122078950 89 - 1.837 1.869 0.109
ENSG00000008311 E018 1.3026600 0.0135014115 9.327059e-01   7 122078951 122079148 198 - 0.316 0.336 0.126
ENSG00000008311 E019 0.9458845 0.0166165085 2.829732e-02   7 122079149 122079327 179 - 0.132 0.523 2.710
ENSG00000008311 E020 0.1723744 0.0404644203 1.373608e-01   7 122079328 122079351 24 - 0.000 0.200 12.245
ENSG00000008311 E021 1.3242015 1.3110243938 6.140647e-01   7 122079352 122079596 245 - 0.279 0.451 1.017
ENSG00000008311 E022 77.8140297 0.0016402711 1.398093e-01 3.471834e-01 7 122079597 122079690 94 - 1.811 1.886 0.253
ENSG00000008311 E023 44.8799476 0.0008185108 6.261664e-01 7.880459e-01 7 122079691 122079712 22 - 1.586 1.622 0.121
ENSG00000008311 E024 69.2054694 0.0014773482 9.910862e-01 9.972640e-01 7 122081500 122081595 96 - 1.780 1.786 0.021
ENSG00000008311 E025 5.2562627 0.0666181797 2.468311e-01 4.845013e-01 7 122082788 122082891 104 - 0.678 0.873 0.778
ENSG00000008311 E026 0.7838716 0.0450420532 2.308522e-01   7 122085578 122085718 141 - 0.276 0.000 -13.070
ENSG00000008311 E027 78.8149622 0.0005447756 4.472783e-01 6.637025e-01 7 122086012 122086115 104 - 1.844 1.814 -0.098
ENSG00000008311 E028 54.6724228 0.0010299920 9.174079e-01 9.609208e-01 7 122086116 122086179 64 - 1.681 1.694 0.043
ENSG00000008311 E029 0.3336024 0.0274424043 3.032456e-02   7 122086180 122086239 60 - 0.000 0.336 13.391
ENSG00000008311 E030 0.1779838 0.0360001533 1.000000e+00   7 122087597 122087694 98 - 0.071 0.000 -10.872
ENSG00000008311 E031 68.6601374 0.0008203452 7.048724e-01 8.386243e-01 7 122091703 122091843 141 - 1.770 1.795 0.083
ENSG00000008311 E032 67.4670366 0.0005649134 8.723333e-01 9.372177e-01 7 122092843 122092951 109 - 1.770 1.769 -0.003
ENSG00000008311 E033 0.3040503 0.0274424043 8.433446e-01   7 122092952 122092982 31 - 0.132 0.000 -11.923
ENSG00000008311 E034 76.1781230 0.0019165196 3.044944e-01 5.450806e-01 7 122093048 122093158 111 - 1.834 1.789 -0.152
ENSG00000008311 E035 78.0959519 0.0027679315 2.444230e-02 1.104894e-01 7 122098450 122098576 127 - 1.859 1.746 -0.382
ENSG00000008311 E036 0.8981014 0.1955806328 9.256078e-01   7 122098577 122098744 168 - 0.237 0.202 -0.293
ENSG00000008311 E037 30.3101014 0.0017398224 2.354788e-01 4.713976e-01 7 122098745 122098748 4 - 1.449 1.365 -0.289
ENSG00000008311 E038 55.2133408 0.0033152843 1.906652e-01 4.177279e-01 7 122098749 122098866 118 - 1.700 1.627 -0.247
ENSG00000008311 E039 43.1587756 0.2298512572 7.729471e-01 8.804713e-01 7 122098867 122100679 1813 - 1.564 1.617 0.181
ENSG00000008311 E040 14.6800059 0.0332819916 5.147083e-01 7.114732e-01 7 122100680 122101370 691 - 1.148 1.061 -0.314
ENSG00000008311 E041 43.5708741 0.0008817285 2.195843e-01 4.529120e-01 7 122101371 122101438 68 - 1.598 1.528 -0.242
ENSG00000008311 E042 7.4127409 0.1327803836 8.907671e-01 9.470528e-01 7 122101439 122101620 182 - 0.854 0.877 0.090
ENSG00000008311 E043 46.8117532 0.0008654437 1.683428e-03 1.490148e-02 7 122101621 122101680 60 - 1.652 1.454 -0.676
ENSG00000008311 E044 62.8765554 0.0007489372 1.001255e-03 9.926212e-03 7 122113118 122113229 112 - 1.775 1.597 -0.604
ENSG00000008311 E045 74.1567146 0.0143793674 2.273375e-02 1.050752e-01 7 122113598 122113720 123 - 1.847 1.673 -0.587
ENSG00000008311 E046 73.6233599 0.0005698445 5.303202e-04 5.951269e-03 7 122115074 122115222 149 - 1.840 1.668 -0.583
ENSG00000008311 E047 58.5260780 0.0007714017 7.164356e-03 4.540500e-02 7 122116633 122116760 128 - 1.737 1.591 -0.499
ENSG00000008311 E048 46.6530428 0.0009055308 1.512375e-02 7.856459e-02 7 122116879 122116957 79 - 1.644 1.496 -0.505
ENSG00000008311 E049 72.9557782 0.0005547639 1.675926e-01 3.873731e-01 7 122118307 122118453 147 - 1.817 1.756 -0.206
ENSG00000008311 E050 54.5482432 0.0008307353 9.770049e-02 2.777694e-01 7 122118563 122118630 68 - 1.698 1.609 -0.299
ENSG00000008311 E051 55.3939633 0.0007498866 3.070175e-01 5.476171e-01 7 122126375 122126459 85 - 1.696 1.645 -0.171
ENSG00000008311 E052 73.6206989 0.0005327779 3.677625e-03 2.735514e-02 7 122129361 122129537 177 - 1.835 1.694 -0.475
ENSG00000008311 E053 76.6112900 0.0004853021 2.812077e-04 3.540708e-03 7 122133517 122133734 218 - 1.860 1.684 -0.595
ENSG00000008311 E054 26.0482067 0.0017270402 2.253352e-01 4.597419e-01 7 122133735 122133741 7 - 1.386 1.294 -0.322
ENSG00000008311 E055 0.1308682 0.0326491905 1.385079e-01   7 122133742 122133822 81 - 0.000 0.199 12.336
ENSG00000008311 E056 36.1184794 0.0017590849 7.479189e-02 2.343991e-01 7 122144161 122144308 148 - 1.529 1.407 -0.420