ENSG00000008086

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379996 ENSG00000008086 HEK293_OSMI2_6hA HEK293_TMG_6hB CDKL5 protein_coding protein_coding 0.752822 0.5348143 1.067379 0.08352053 0.04942662 0.9836892 0.063731986 0.00000000 0.05916930 0.00000000 0.03062614 2.7901319 0.06865833 0.00000000 0.05293333 0.05293333 0.6317204668 0.0007179646 FALSE TRUE
ENST00000463994 ENSG00000008086 HEK293_OSMI2_6hA HEK293_TMG_6hB CDKL5 protein_coding protein_coding 0.752822 0.5348143 1.067379 0.08352053 0.04942662 0.9836892 0.098548801 0.00000000 0.32070926 0.00000000 0.02238187 5.0474915 0.08931250 0.00000000 0.30370000 0.30370000 0.0007179646 0.0007179646 FALSE TRUE
ENST00000623535 ENSG00000008086 HEK293_OSMI2_6hA HEK293_TMG_6hB CDKL5 protein_coding protein_coding 0.752822 0.5348143 1.067379 0.08352053 0.04942662 0.9836892 0.418223558 0.19946373 0.55937982 0.10015963 0.08090650 1.4426909 0.60372500 0.44043333 0.51940000 0.07896667 0.9469760364 0.0007179646 FALSE TRUE
ENST00000623610 ENSG00000008086 HEK293_OSMI2_6hA HEK293_TMG_6hB CDKL5 protein_coding retained_intron 0.752822 0.5348143 1.067379 0.08352053 0.04942662 0.9836892 0.057340233 0.07054058 0.07972570 0.03945033 0.03308340 0.1558054 0.08457500 0.15976667 0.07530000 -0.08446667 0.8456321444 0.0007179646 FALSE TRUE
ENST00000673617 ENSG00000008086 HEK293_OSMI2_6hA HEK293_TMG_6hB CDKL5 protein_coding processed_transcript 0.752822 0.5348143 1.067379 0.08352053 0.04942662 0.9836892 0.007248776 0.05799021 0.00000000 0.05799021 0.00000000 -2.7653270 0.01039583 0.08316667 0.00000000 -0.08316667 0.7919430460 0.0007179646 FALSE FALSE
ENST00000674046 ENSG00000008086 HEK293_OSMI2_6hA HEK293_TMG_6hB CDKL5 protein_coding protein_coding 0.752822 0.5348143 1.067379 0.08352053 0.04942662 0.9836892 0.081533418 0.20064187 0.03861486 0.15458108 0.03861486 -2.1153231 0.11910000 0.30776667 0.03983333 -0.26793333 0.6170334168 0.0007179646 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000008086 E001 0.0000000       X 18425583 18425607 25 +      
ENSG00000008086 E002 1.1089159 0.0151386598 1.822608e-02   X 18425608 18425695 88 + 0.449 0.000 -11.915
ENSG00000008086 E003 0.0000000       X 18426198 18426401 204 +      
ENSG00000008086 E004 0.5365243 0.0225483315 3.306932e-01   X 18426713 18426919 207 + 0.100 0.257 1.640
ENSG00000008086 E005 0.0000000       X 18442188 18442212 25 +      
ENSG00000008086 E006 0.0000000       X 18442213 18442223 11 +      
ENSG00000008086 E007 0.0000000       X 18442224 18442227 4 +      
ENSG00000008086 E008 0.0000000       X 18442228 18442261 34 +      
ENSG00000008086 E009 0.0000000       X 18442262 18442274 13 +      
ENSG00000008086 E010 0.0000000       X 18442275 18442374 100 +      
ENSG00000008086 E011 0.0000000       X 18442375 18442390 16 +      
ENSG00000008086 E012 0.0000000       X 18442391 18442423 33 +      
ENSG00000008086 E013 0.0000000       X 18443819 18443959 141 +      
ENSG00000008086 E014 0.0000000       X 18457483 18457534 52 +      
ENSG00000008086 E015 0.0000000       X 18497318 18497378 61 +      
ENSG00000008086 E016 5.0335909 0.0081385173 5.277253e-03 3.606479e-02 X 18506935 18507160 226 + 0.902 0.478 -1.799
ENSG00000008086 E017 3.1996856 0.0093067492 2.254622e-02 1.043828e-01 X 18510820 18510854 35 + 0.732 0.344 -1.868
ENSG00000008086 E018 4.7792290 0.0204657758 4.268606e-02 1.617447e-01 X 18564477 18564522 46 + 0.858 0.533 -1.364
ENSG00000008086 E019 7.0809152 0.0615648760 1.693140e-01 3.896759e-01 X 18575354 18575490 137 + 0.979 0.735 -0.943
ENSG00000008086 E020 3.8716424 0.0072827062 6.518814e-02 2.142983e-01 X 18579848 18579968 121 + 0.772 0.479 -1.288
ENSG00000008086 E021 1.8600271 0.1118307381 3.734262e-02 1.478443e-01 X 18581891 18581950 60 + 0.584 0.146 -2.827
ENSG00000008086 E022 2.3835675 0.0703203126 1.066783e-02 6.097753e-02 X 18584263 18584353 91 + 0.664 0.147 -3.164
ENSG00000008086 E023 0.0000000       X 18587686 18587953 268 +      
ENSG00000008086 E024 4.5386885 0.0092993866 1.057830e-01 2.919661e-01 X 18587954 18588143 190 + 0.825 0.581 -1.018
ENSG00000008086 E025 0.0000000       X 18588144 18589815 1672 +      
ENSG00000008086 E026 2.8979638 0.0083291543 9.827449e-01 9.931134e-01 X 18595348 18595428 81 + 0.585 0.581 -0.017
ENSG00000008086 E027 5.4492711 0.1218238861 5.272656e-01 7.200396e-01 X 18598462 18598613 152 + 0.850 0.702 -0.591
ENSG00000008086 E028 18.2911951 0.0117501850 1.597391e-03 1.430769e-02 X 18603902 18604868 967 + 1.373 1.058 -1.117
ENSG00000008086 E029 4.1262940 0.0067651260 1.246866e-01 3.232427e-01 X 18608811 18608912 102 + 0.772 0.534 -1.025
ENSG00000008086 E030 5.0091850 0.0628963576 4.601598e-01 6.732231e-01 X 18609465 18609570 106 + 0.823 0.699 -0.498
ENSG00000008086 E031 4.6722020 0.0092409928 1.725121e-01 3.938180e-01 X 18613152 18613275 124 + 0.825 0.624 -0.826
ENSG00000008086 E032 2.3917994 0.0091465325 6.697099e-01 8.161016e-01 X 18619867 18619966 100 + 0.555 0.478 -0.366
ENSG00000008086 E033 0.8817055 0.0925236492 8.166326e-02   X 18623879 18624001 123 + 0.100 0.420 2.660
ENSG00000008086 E034 3.2793020 0.0073200767 7.355711e-01 8.576512e-01 X 18625128 18625247 120 + 0.640 0.582 -0.257
ENSG00000008086 E035 0.3807181 0.0283311507 7.360639e-01   X 18626774 18627734 961 + 0.100 0.147 0.638
ENSG00000008086 E036 4.6832782 0.0057183182 2.153491e-01 4.479142e-01 X 18628371 18628587 217 + 0.809 0.625 -0.757
ENSG00000008086 E037 147.1384001 0.0005882734 3.025002e-16 5.390503e-14 X 18628588 18640196 11609 + 2.097 2.234 0.458
ENSG00000008086 E038 0.1614157 0.0317040594 7.491910e-01   X 18646007 18646090 84 + 0.100 0.000 -11.506
ENSG00000008086 E039 0.0000000       X 18649804 18649872 69 +      
ENSG00000008086 E040 0.2027342 0.0320370390 3.103234e-01   X 18650410 18650592 183 + 0.000 0.147 10.996
ENSG00000008086 E041 0.2027342 0.0320370390 3.103234e-01   X 18653432 18653629 198 + 0.000 0.147 10.996