ENSG00000008083

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341776 ENSG00000008083 HEK293_OSMI2_6hA HEK293_TMG_6hB JARID2 protein_coding protein_coding 7.986174 8.917035 9.861961 0.9568123 0.1598196 0.1451556 4.4509595 4.6447619 6.7412845 0.6131808 0.2427506 0.5364546 0.5435375 0.52546667 0.68390000 0.15843333 0.360978377 0.002558116 FALSE TRUE
ENST00000397311 ENSG00000008083 HEK293_OSMI2_6hA HEK293_TMG_6hB JARID2 protein_coding protein_coding 7.986174 8.917035 9.861961 0.9568123 0.1598196 0.1451556 1.5372805 2.5440844 0.6188509 0.5963620 0.1000885 -2.0220162 0.2054000 0.28770000 0.06253333 -0.22516667 0.002558116 0.002558116 FALSE TRUE
MSTRG.27673.5 ENSG00000008083 HEK293_OSMI2_6hA HEK293_TMG_6hB JARID2 protein_coding   7.986174 8.917035 9.861961 0.9568123 0.1598196 0.1451556 1.1473435 1.3604875 1.1259141 0.6211213 0.2602466 -0.2708355 0.1461792 0.14303333 0.11356667 -0.02946667 0.946895662 0.002558116 FALSE TRUE
MSTRG.27673.6 ENSG00000008083 HEK293_OSMI2_6hA HEK293_TMG_6hB JARID2 protein_coding   7.986174 8.917035 9.861961 0.9568123 0.1598196 0.1451556 0.6373575 0.2518003 1.1641261 0.2518003 0.2884944 2.1650484 0.0769875 0.02763333 0.11816667 0.09053333 0.288820320 0.002558116 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000008083 E001 0.0000000       6 15244800 15244945 146 +      
ENSG00000008083 E002 0.1723744 0.0338695518 5.364299e-01   6 15244946 15244999 54 + 0.000 0.117 9.265
ENSG00000008083 E003 0.7429130 0.6728458650 5.106109e-01   6 15245000 15245032 33 + 0.359 0.118 -2.042
ENSG00000008083 E004 0.1723744 0.0338695518 5.364299e-01   6 15245314 15245484 171 + 0.000 0.117 9.272
ENSG00000008083 E005 1.1190667 0.0153787590 6.043215e-01   6 15245485 15245519 35 + 0.372 0.284 -0.552
ENSG00000008083 E006 3.6143095 0.0074773047 7.930876e-01 8.922518e-01 6 15245520 15245607 88 + 0.674 0.642 -0.137
ENSG00000008083 E007 49.8049769 0.0009062692 1.584247e-04 2.200209e-03 6 15246069 15246380 312 + 1.787 1.603 -0.622
ENSG00000008083 E008 66.2798548 0.0047761875 1.844733e-06 4.854766e-05 6 15246381 15246584 204 + 1.939 1.689 -0.843
ENSG00000008083 E009 4.7194440 0.0435389548 2.147538e-01 4.472119e-01 6 15248855 15248964 110 + 0.643 0.850 0.844
ENSG00000008083 E010 66.7725113 0.0011310073 8.739491e-05 1.335103e-03 6 15374117 15374252 136 + 1.906 1.737 -0.568
ENSG00000008083 E011 49.7859079 0.0009890960 5.973173e-02 2.021809e-01 6 15410224 15410365 142 + 1.746 1.659 -0.295
ENSG00000008083 E012 72.7974209 0.0005938748 2.701233e-03 2.157805e-02 6 15452006 15452175 170 + 1.920 1.803 -0.394
ENSG00000008083 E013 86.4419513 0.0005040400 9.362956e-05 1.415261e-03 6 15468542 15468718 177 + 2.008 1.867 -0.473
ENSG00000008083 E014 80.1707028 0.0010231554 4.016080e-02 1.551221e-01 6 15487307 15487542 236 + 1.946 1.871 -0.254
ENSG00000008083 E015 21.5627074 0.0016910324 3.781139e-01 6.106108e-01 6 15496132 15496140 9 + 1.380 1.323 -0.200
ENSG00000008083 E016 188.1029004 0.0002382178 3.179600e-05 5.674330e-04 6 15496141 15497055 915 + 2.322 2.224 -0.325
ENSG00000008083 E017 53.4681296 0.0030831455 1.538448e-01 3.678166e-01 6 15497056 15497170 115 + 1.770 1.703 -0.226
ENSG00000008083 E018 140.4460722 0.0034537354 1.635644e-01 3.820455e-01 6 15500907 15501357 451 + 2.173 2.128 -0.152
ENSG00000008083 E019 56.5677426 0.0049546274 3.942937e-01 6.238216e-01 6 15501358 15501409 52 + 1.779 1.739 -0.135
ENSG00000008083 E020 77.9888179 0.0008215315 7.466907e-01 8.647508e-01 6 15504500 15504592 93 + 1.897 1.892 -0.017
ENSG00000008083 E021 0.5227326 0.3515580292 7.174953e-01   6 15505165 15505295 131 + 0.128 0.211 0.869
ENSG00000008083 E022 90.6504851 0.0004357738 9.896571e-01 9.965578e-01 6 15507136 15507254 119 + 1.956 1.964 0.029
ENSG00000008083 E023 70.0495551 0.0008921813 3.497611e-01 5.870650e-01 6 15507346 15507416 71 + 1.826 1.874 0.164
ENSG00000008083 E024 92.7295022 0.0009167786 3.659102e-02 1.458274e-01 6 15508340 15508454 115 + 1.920 2.009 0.298
ENSG00000008083 E025 81.9113161 0.0005559321 4.562411e-02 1.690858e-01 6 15511296 15511401 106 + 1.866 1.953 0.293
ENSG00000008083 E026 103.5771359 0.0004169939 2.389236e-01 4.753643e-01 6 15512208 15512390 183 + 1.989 2.038 0.165
ENSG00000008083 E027 81.0233377 0.0005680866 7.011247e-01 8.363568e-01 6 15512915 15513045 131 + 1.900 1.923 0.078
ENSG00000008083 E028 101.6626140 0.0003770191 5.387526e-01 7.281196e-01 6 15513239 15513422 184 + 1.993 2.023 0.100
ENSG00000008083 E029 86.3281712 0.0004590784 3.239780e-01 5.632914e-01 6 15517161 15517268 108 + 1.913 1.959 0.154
ENSG00000008083 E030 96.6562308 0.0006063585 5.220323e-02 1.848538e-01 6 15520069 15520290 222 + 1.939 2.019 0.268
ENSG00000008083 E031 214.2560004 0.0002878932 6.264755e-11 4.625650e-09 6 15520291 15520910 620 + 2.233 2.401 0.560
ENSG00000008083 E032 285.6457185 0.0056796313 1.606178e-04 2.225389e-03 6 15520911 15522195 1285 + 2.363 2.523 0.534