ENSG00000007923

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000294401 ENSG00000007923 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAJC11 protein_coding protein_coding 71.51601 88.3247 58.27585 8.898629 1.544963 -0.5998346 2.974200 2.174533 5.634749 0.5793517 0.8087995 1.3695845 0.04650833 0.02383333 0.09616667 0.07233333 0.0001352383 0.0001352383 FALSE TRUE
ENST00000377577 ENSG00000007923 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAJC11 protein_coding protein_coding 71.51601 88.3247 58.27585 8.898629 1.544963 -0.5998346 56.833873 74.637767 40.116940 11.1323946 1.0652431 -0.8955280 0.78153750 0.83573333 0.68900000 -0.14673333 0.2347156597 0.0001352383 FALSE TRUE
ENST00000691481 ENSG00000007923 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAJC11 protein_coding retained_intron 71.51601 88.3247 58.27585 8.898629 1.544963 -0.5998346 3.631779 4.313244 3.199053 0.8766216 0.2511108 -0.4299666 0.05230000 0.05203333 0.05473333 0.00270000 0.9492439455 0.0001352383 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000007923 E001 0.0000000       1 6630569 6630596 28 -      
ENSG00000007923 E002 3.5761409 0.9140596822 6.820882e-01 0.824014995 1 6632029 6634167 2139 - 0.850 0.454 -1.720
ENSG00000007923 E003 6.2807207 0.0525910860 3.866524e-01 0.617809728 1 6634168 6634169 2 - 0.723 0.895 0.675
ENSG00000007923 E004 22.3401961 0.2732654818 2.723785e-01 0.512234726 1 6634170 6634182 13 - 1.198 1.415 0.758
ENSG00000007923 E005 22.5125705 0.2751093305 2.672795e-01 0.506903857 1 6634183 6634183 1 - 1.198 1.419 0.772
ENSG00000007923 E006 24.2878155 0.2673970040 2.506762e-01 0.488719248 1 6634184 6634185 2 - 1.221 1.453 0.808
ENSG00000007923 E007 59.4022674 0.5176003919 2.204878e-01 0.454088525 1 6634186 6634210 25 - 1.537 1.848 1.052
ENSG00000007923 E008 761.0420618 1.6255110072 3.979129e-01 0.626695388 1 6634211 6634784 574 - 2.598 2.958 1.197
ENSG00000007923 E009 811.9778451 1.6563948619 4.149451e-01 0.639782744 1 6634785 6635112 328 - 2.639 2.983 1.143
ENSG00000007923 E010 1045.2414624 0.1881024856 1.502991e-01 0.362721945 1 6635113 6635644 532 - 2.819 3.073 0.843
ENSG00000007923 E011 383.7420838 0.0001533760 1.721390e-02 0.086230960 1 6635645 6635700 56 - 2.500 2.596 0.320
ENSG00000007923 E012 633.0026117 0.0007133122 1.105814e-01 0.299940418 1 6636117 6636246 130 - 2.727 2.808 0.269
ENSG00000007923 E013 723.7272597 0.0038017769 9.124070e-01 0.958336646 1 6637198 6637340 143 - 2.803 2.859 0.184
ENSG00000007923 E014 14.3950964 0.0645614462 1.097656e-01 0.298657724 1 6637341 6637446 106 - 1.274 1.099 -0.624
ENSG00000007923 E015 480.5810528 0.0050538360 7.673121e-01 0.876987898 1 6637447 6637504 58 - 2.620 2.684 0.211
ENSG00000007923 E016 42.4140072 0.1353383245 1.525440e-01 0.365982907 1 6637505 6638082 578 - 1.706 1.561 -0.495
ENSG00000007923 E017 20.7287907 0.0808353621 4.292744e-01 0.650486483 1 6638083 6638294 212 - 1.352 1.301 -0.176
ENSG00000007923 E018 483.1448377 0.0035385151 8.768112e-01 0.939608594 1 6638295 6638364 70 - 2.626 2.684 0.193
ENSG00000007923 E019 17.4824258 0.1129600780 2.204528e-01 0.454068415 1 6638365 6639530 1166 - 1.332 1.196 -0.477
ENSG00000007923 E020 679.1359034 0.0060333244 6.285928e-01 0.789649137 1 6639902 6640057 156 - 2.790 2.824 0.112
ENSG00000007923 E021 634.0395987 0.0042374366 1.460407e-01 0.356435854 1 6644558 6644669 112 - 2.780 2.784 0.013
ENSG00000007923 E022 317.5626013 0.0025311717 1.193708e-02 0.066187526 1 6644670 6644674 5 - 2.500 2.472 -0.092
ENSG00000007923 E023 1.0765154 0.2150227879 4.044178e-01   1 6644969 6645040 72 - 0.430 0.237 -1.221
ENSG00000007923 E024 585.5245901 0.0043411851 7.359350e-02 0.231948293 1 6645041 6645126 86 - 2.754 2.744 -0.032
ENSG00000007923 E025 13.6731167 0.0780756729 2.842289e-02 0.122580706 1 6645127 6645788 662 - 1.313 1.034 -0.995
ENSG00000007923 E026 341.5139917 0.0056207006 2.078228e-01 0.439198149 1 6645789 6645799 11 - 2.515 2.515 -0.001
ENSG00000007923 E027 546.1778256 0.0035412064 1.381281e-01 0.344656595 1 6645800 6645870 71 - 2.715 2.719 0.013
ENSG00000007923 E028 307.7583266 0.0015332949 6.291443e-02 0.209250239 1 6645871 6645875 5 - 2.470 2.468 -0.009
ENSG00000007923 E029 583.0670493 0.0020041376 5.058154e-03 0.034938214 1 6645876 6645978 103 - 2.760 2.738 -0.073
ENSG00000007923 E030 171.7122070 0.0753868663 1.840128e-01 0.409169618 1 6645979 6647076 1098 - 2.276 2.182 -0.314
ENSG00000007923 E031 39.6886492 0.0980152326 7.869417e-01 0.888716858 1 6647340 6647780 441 - 1.578 1.597 0.062
ENSG00000007923 E032 39.4858718 0.1409024472 2.894220e-01 0.529941813 1 6650570 6651016 447 - 1.638 1.559 -0.269
ENSG00000007923 E033 42.0988669 0.1510271726 2.553315e-01 0.493969797 1 6651017 6651180 164 - 1.676 1.577 -0.334
ENSG00000007923 E034 61.0218513 0.1256415825 9.029367e-02 0.264309955 1 6651181 6651528 348 - 1.885 1.696 -0.636
ENSG00000007923 E035 436.0695496 0.0021745006 2.161728e-03 0.018153149 1 6651529 6651602 74 - 2.643 2.609 -0.114
ENSG00000007923 E036 6.6787914 0.0915721745 3.319356e-01 0.570769187 1 6652650 6652663 14 - 0.943 0.828 -0.442
ENSG00000007923 E037 14.2015062 0.0929217296 2.862669e-02 0.123243677 1 6652664 6652828 165 - 1.329 1.038 -1.037
ENSG00000007923 E038 408.5691957 0.0020356535 1.333690e-04 0.001902329 1 6652829 6652913 85 - 2.628 2.573 -0.182
ENSG00000007923 E039 332.0560713 0.0009021055 2.096409e-03 0.017711478 1 6652914 6652951 38 - 2.521 2.496 -0.083
ENSG00000007923 E040 19.0534795 0.1068422377 6.603651e-02 0.216200165 1 6652952 6653387 436 - 1.433 1.168 -0.928
ENSG00000007923 E041 18.9939138 0.0623453021 5.633336e-02 0.194409558 1 6653388 6653808 421 - 1.403 1.197 -0.720
ENSG00000007923 E042 9.5991209 0.0144190965 6.767153e-01 0.820660550 1 6653809 6653910 102 - 1.004 0.997 -0.026
ENSG00000007923 E043 485.5408565 0.0008332486 1.587936e-03 0.014236517 1 6653911 6654039 129 - 2.680 2.663 -0.056
ENSG00000007923 E044 1.4832166 0.0127392264 1.772539e-01 0.400119425 1 6654108 6654287 180 - 0.500 0.293 -1.170
ENSG00000007923 E045 3.4144040 0.0688041365 2.066423e-01 0.437683771 1 6666597 6667708 1112 - 0.728 0.538 -0.827
ENSG00000007923 E046 450.9497458 0.0033933276 7.213296e-03 0.045638525 1 6667709 6667810 102 - 2.658 2.623 -0.117
ENSG00000007923 E047 0.0000000       1 6668125 6668210 86 -      
ENSG00000007923 E048 3.2766566 0.0259096834 7.087250e-03 0.045018818 1 6670461 6670910 450 - 0.822 0.429 -1.744
ENSG00000007923 E049 450.6789565 0.0035332046 7.472674e-04 0.007837884 1 6678394 6678467 74 - 2.673 2.613 -0.202
ENSG00000007923 E050 550.7830784 0.0038509266 1.682169e-04 0.002314063 1 6680908 6681037 130 - 2.768 2.694 -0.246
ENSG00000007923 E051 0.4397201 0.1150137205 9.707898e-01   1 6691221 6691831 611 - 0.157 0.168 0.120
ENSG00000007923 E052 325.3489580 0.0031697666 4.506207e-05 0.000761602 1 6701729 6701924 196 - 2.547 2.461 -0.288