ENSG00000007516

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000426824 ENSG00000007516 HEK293_OSMI2_6hA HEK293_TMG_6hB BAIAP3 protein_coding protein_coding 4.029926 5.204134 2.596252 1.467034 0.4454356 -1.000451 0.6936320 1.2170349 0.04896317 0.05750115 0.04896317 -4.3792184 0.17126250 0.26460000 0.01813333 -0.24646667 0.02206683 0.02206683 FALSE TRUE
ENST00000565665 ENSG00000007516 HEK293_OSMI2_6hA HEK293_TMG_6hB BAIAP3 protein_coding retained_intron 4.029926 5.204134 2.596252 1.467034 0.4454356 -1.000451 0.2780891 0.2710703 0.32337432 0.20153591 0.17053280 0.2462120 0.06405833 0.03880000 0.10656667 0.06776667 0.82098630 0.02206683 FALSE TRUE
ENST00000567203 ENSG00000007516 HEK293_OSMI2_6hA HEK293_TMG_6hB BAIAP3 protein_coding retained_intron 4.029926 5.204134 2.596252 1.467034 0.4454356 -1.000451 0.6224975 0.7555844 0.40215995 0.60381565 0.15918806 -0.8933571 0.13994583 0.10823333 0.14900000 0.04076667 0.81549263 0.02206683 FALSE FALSE
MSTRG.11774.1 ENSG00000007516 HEK293_OSMI2_6hA HEK293_TMG_6hB BAIAP3 protein_coding   4.029926 5.204134 2.596252 1.467034 0.4454356 -1.000451 0.3908022 0.4289786 0.38604726 0.04135644 0.02523369 -0.1484780 0.10836250 0.09196667 0.16283333 0.07086667 0.65166112 0.02206683 FALSE TRUE
MSTRG.11774.14 ENSG00000007516 HEK293_OSMI2_6hA HEK293_TMG_6hB BAIAP3 protein_coding   4.029926 5.204134 2.596252 1.467034 0.4454356 -1.000451 0.4985288 0.8866397 0.20744339 0.33501579 0.10379183 -2.0438885 0.12071250 0.16093333 0.06986667 -0.09106667 0.51130744 0.02206683 TRUE TRUE
MSTRG.11774.15 ENSG00000007516 HEK293_OSMI2_6hA HEK293_TMG_6hB BAIAP3 protein_coding   4.029926 5.204134 2.596252 1.467034 0.4454356 -1.000451 0.3329171 0.6169913 0.10773426 0.08042797 0.10773426 -2.4129113 0.08488333 0.14593333 0.06063333 -0.08530000 0.50226498 0.02206683 FALSE TRUE
MSTRG.11774.7 ENSG00000007516 HEK293_OSMI2_6hA HEK293_TMG_6hB BAIAP3 protein_coding   4.029926 5.204134 2.596252 1.467034 0.4454356 -1.000451 0.3234906 0.3709074 0.40133774 0.07531795 0.06323941 0.1108831 0.08745000 0.07476667 0.15860000 0.08383333 0.18877314 0.02206683 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000007516 E001 0.0000000       16 1333638 1333642 5 +      
ENSG00000007516 E002 0.1308682 0.032215116 1.0000000000   16 1333643 1333644 2 + 0.000 0.077 8.768
ENSG00000007516 E003 0.4644705 0.074032909 0.3961275621   16 1333645 1333653 9 + 0.000 0.198 12.795
ENSG00000007516 E004 1.0008072 0.435928340 0.1952841167   16 1333654 1333657 4 + 0.000 0.336 13.213
ENSG00000007516 E005 5.0047951 0.038011254 0.2384654954 0.47486458 16 1333658 1333749 92 + 0.566 0.770 0.867
ENSG00000007516 E006 2.1345318 0.030078030 0.6830527153 0.82458192 16 1334504 1334756 253 + 0.499 0.439 -0.303
ENSG00000007516 E007 2.8768997 0.076370726 0.0244928914 0.11064149 16 1336197 1336399 203 + 0.810 0.373 -2.003
ENSG00000007516 E008 11.4179404 0.002936956 0.5034078058 0.70316026 16 1338540 1338680 141 + 0.983 1.058 0.276
ENSG00000007516 E009 10.5327752 0.003337343 0.0803746726 0.24559562 16 1338902 1338989 88 + 1.144 0.959 -0.673
ENSG00000007516 E010 1.1838505 0.131254993 0.9163007125   16 1339113 1339163 51 + 0.316 0.330 0.091
ENSG00000007516 E011 10.2608049 0.050139876 0.6682387882 0.81505915 16 1339164 1339244 81 + 1.068 0.982 -0.315
ENSG00000007516 E012 2.9419861 0.093063576 0.1363481756 0.34191840 16 1339245 1339386 142 + 0.726 0.469 -1.156
ENSG00000007516 E013 8.9839609 0.040381337 0.2723796688 0.51223473 16 1339496 1339564 69 + 1.070 0.892 -0.660
ENSG00000007516 E014 8.5901912 0.059817108 0.5137392302 0.71073984 16 1339565 1339579 15 + 1.027 0.898 -0.484
ENSG00000007516 E015 7.8176535 0.004607993 0.7400716511 0.86048196 16 1339580 1339603 24 + 0.931 0.890 -0.159
ENSG00000007516 E016 9.9439895 0.003193111 0.4135407164 0.63866358 16 1340922 1340981 60 + 1.051 0.960 -0.335
ENSG00000007516 E017 11.5135180 0.003544521 0.0243405544 0.11013791 16 1341129 1341195 67 + 1.207 0.977 -0.830
ENSG00000007516 E018 16.7558644 0.002434646 0.0220488472 0.10274679 16 1341294 1341489 196 + 1.332 1.132 -0.707
ENSG00000007516 E019 8.1772054 0.004540094 0.1737017975 0.39547077 16 1341822 1341866 45 + 1.029 0.867 -0.607
ENSG00000007516 E020 7.3760640 0.004074676 0.0005444863 0.00607811 16 1341867 1341985 119 + 1.127 0.720 -1.543
ENSG00000007516 E021 11.5219721 0.028546968 0.4881376648 0.69276011 16 1341986 1342063 78 + 1.111 1.008 -0.375
ENSG00000007516 E022 14.2544468 0.003125344 0.1431626091 0.35222461 16 1342181 1342283 103 + 1.221 1.080 -0.505
ENSG00000007516 E023 1.8672587 0.014988998 0.1798027055 0.40369437 16 1342284 1342421 138 + 0.568 0.335 -1.213
ENSG00000007516 E024 13.5712220 0.036388253 0.6415062108 0.79782722 16 1342527 1342634 108 + 1.163 1.083 -0.287
ENSG00000007516 E025 12.7532864 0.023242168 0.9301050004 0.96706623 16 1342719 1342814 96 + 1.073 1.077 0.016
ENSG00000007516 E026 4.3849841 0.006347843 0.1402247494 0.34784382 16 1342815 1342912 98 + 0.840 0.631 -0.853
ENSG00000007516 E027 14.1144203 0.029791904 0.2292250316 0.46422060 16 1342913 1343016 104 + 0.983 1.172 0.689
ENSG00000007516 E028 0.8855973 0.028336272 0.7087964961   16 1343318 1343392 75 + 0.318 0.248 -0.487
ENSG00000007516 E029 15.3208964 0.014159448 0.7486537135 0.86590818 16 1343393 1343513 121 + 1.127 1.177 0.180
ENSG00000007516 E030 0.1723744 0.032649190 1.0000000000   16 1343890 1344021 132 + 0.000 0.077 11.425
ENSG00000007516 E031 8.4693937 0.004014274 0.5573403130 0.74136983 16 1344022 1344044 23 + 0.873 0.950 0.291
ENSG00000007516 E032 14.2581803 0.002510454 0.4142493025 0.63923472 16 1344045 1344146 102 + 1.071 1.156 0.306
ENSG00000007516 E033 3.7616577 0.035178052 0.5866909603 0.76139054 16 1344147 1344226 80 + 0.567 0.652 0.375
ENSG00000007516 E034 15.8116973 0.008661894 0.5052688368 0.70449027 16 1344227 1344317 91 + 1.109 1.182 0.259
ENSG00000007516 E035 15.5938904 0.002116204 0.7760415467 0.88238752 16 1344469 1344525 57 + 1.144 1.174 0.105
ENSG00000007516 E036 6.4496279 0.004505610 0.0126863665 0.06919662 16 1344526 1344600 75 + 1.029 0.720 -1.190
ENSG00000007516 E037 10.5168902 0.003517946 0.5532268214 0.73853874 16 1344601 1344667 67 + 0.958 1.028 0.258
ENSG00000007516 E038 6.9132522 0.004086629 0.1220640501 0.31911838 16 1344668 1344698 31 + 0.679 0.900 0.882
ENSG00000007516 E039 10.4629118 0.003764530 0.0075743417 0.04737220 16 1344798 1344849 52 + 0.725 1.073 1.328
ENSG00000007516 E040 17.0531385 0.015675362 0.2943192649 0.53491203 16 1344969 1345099 131 + 1.126 1.230 0.370
ENSG00000007516 E041 16.2598827 0.002485684 0.8878385324 0.94547068 16 1345249 1345372 124 + 1.176 1.190 0.047
ENSG00000007516 E042 1.6768882 0.030166302 0.6917572142 0.83018590 16 1345418 1345746 329 + 0.318 0.407 0.523
ENSG00000007516 E043 20.1360026 0.002182903 0.4881622324 0.69277017 16 1345747 1345890 144 + 1.221 1.282 0.216
ENSG00000007516 E044 11.9347891 0.002785270 0.3631546849 0.59826374 16 1345986 1346008 23 + 1.127 1.035 -0.331
ENSG00000007516 E045 15.0081256 0.002389389 0.4166354500 0.64115738 16 1346009 1346078 70 + 1.207 1.132 -0.266
ENSG00000007516 E046 11.8802761 0.006125287 0.8527237256 0.92653654 16 1346170 1346220 51 + 1.071 1.058 -0.050
ENSG00000007516 E047 9.2334882 0.012366028 0.5792059259 0.75660531 16 1346221 1346237 17 + 1.007 0.950 -0.213
ENSG00000007516 E048 20.0998149 0.042933421 0.8046227541 0.89897402 16 1346238 1346361 124 + 1.262 1.276 0.047
ENSG00000007516 E049 13.9705252 0.025581097 0.6960983166 0.83300570 16 1346442 1346458 17 + 1.144 1.118 -0.093
ENSG00000007516 E050 19.2560980 0.002396146 0.8726513916 0.93739915 16 1346459 1346510 52 + 1.261 1.251 -0.037
ENSG00000007516 E051 18.8286559 0.002361464 0.1227050596 0.32001376 16 1346605 1346684 80 + 1.127 1.274 0.521
ENSG00000007516 E052 0.6479912 0.020788998 0.2568208612   16 1346685 1346718 34 + 0.000 0.249 13.321
ENSG00000007516 E053 2.9198085 0.096000099 0.2493219240 0.48711585 16 1346719 1346846 128 + 0.678 0.497 -0.816
ENSG00000007516 E054 12.2245862 0.003221926 0.7440905931 0.86305747 16 1346847 1346933 87 + 1.090 1.058 -0.117
ENSG00000007516 E055 9.0522936 0.012898968 0.8342548879 0.91616443 16 1346934 1346955 22 + 0.959 0.942 -0.063
ENSG00000007516 E056 7.9192426 0.141318191 0.9970842619 1.00000000 16 1346956 1347091 136 + 0.844 0.912 0.262
ENSG00000007516 E057 19.1602848 0.053552634 0.8707342794 0.93638177 16 1347298 1347369 72 + 1.269 1.242 -0.095
ENSG00000007516 E058 23.5356567 0.002571942 0.1339632462 0.33804426 16 1347545 1347625 81 + 1.235 1.366 0.457
ENSG00000007516 E059 26.1650265 0.001328448 0.1829660375 0.40780522 16 1347701 1347821 121 + 1.298 1.404 0.368
ENSG00000007516 E060 23.2000491 0.011953442 0.2811844497 0.52147063 16 1347894 1348017 124 + 1.261 1.354 0.326
ENSG00000007516 E061 23.8136866 0.002862131 0.4525246033 0.66753314 16 1348096 1348208 113 + 1.298 1.358 0.211
ENSG00000007516 E062 22.5579700 0.001921583 0.4543644881 0.66901523 16 1348209 1348301 93 + 1.274 1.336 0.217
ENSG00000007516 E063 95.7411801 0.003540310 0.1478801127 0.35925665 16 1348379 1349365 987 + 1.880 1.944 0.216
ENSG00000007516 E064 5.0471766 0.008564112 0.3358369343 0.57427402 16 1349366 1349441 76 + 0.627 0.779 0.634