ENSG00000007376

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000007264 ENSG00000007376 HEK293_OSMI2_6hA HEK293_TMG_6hB RPUSD1 protein_coding protein_coding 126.7185 189.7797 59.86588 36.78477 1.162949 -1.664355 62.001295 98.85951 24.471705 26.9398753 3.7529043 -2.0138217 0.45866667 0.50166667 0.40670000 -9.496667e-02 0.730673734 7.815739e-05 FALSE TRUE
ENST00000561734 ENSG00000007376 HEK293_OSMI2_6hA HEK293_TMG_6hB RPUSD1 protein_coding protein_coding 126.7185 189.7797 59.86588 36.78477 1.162949 -1.664355 10.658475 12.84190 9.190870 2.7450939 0.2472564 -0.4821397 0.10682500 0.07953333 0.15373333 7.420000e-02 0.385910213 7.815739e-05 FALSE TRUE
ENST00000562070 ENSG00000007376 HEK293_OSMI2_6hA HEK293_TMG_6hB RPUSD1 protein_coding protein_coding 126.7185 189.7797 59.86588 36.78477 1.162949 -1.664355 8.759146 10.82421 7.541768 0.7993619 0.1378744 -0.5207070 0.08116250 0.06030000 0.12603333 6.573333e-02 0.007091291 7.815739e-05 FALSE TRUE
ENST00000565809 ENSG00000007376 HEK293_OSMI2_6hA HEK293_TMG_6hB RPUSD1 protein_coding protein_coding 126.7185 189.7797 59.86588 36.78477 1.162949 -1.664355 9.130031 14.40998 4.436721 3.7536153 0.4484079 -1.6972555 0.07422917 0.07430000 0.07436667 6.666667e-05 1.000000000 7.815739e-05 FALSE FALSE
ENST00000567114 ENSG00000007376 HEK293_OSMI2_6hA HEK293_TMG_6hB RPUSD1 protein_coding protein_coding 126.7185 189.7797 59.86588 36.78477 1.162949 -1.664355 20.334131 27.67015 5.936810 4.9679405 2.3444719 -2.2186637 0.14543333 0.14690000 0.10073333 -4.616667e-02 0.763680577 7.815739e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000007376 E001 60.28194 0.0138069975 7.544592e-01 8.693885e-01 16 784974 784990 17 - 1.711 1.697 -0.048
ENSG00000007376 E002 135.46441 0.0028226807 7.783847e-02 2.404898e-01 16 784991 785013 23 - 1.974 2.064 0.303
ENSG00000007376 E003 563.88105 0.0004523189 6.920214e-01 8.303504e-01 16 785014 785139 126 - 2.660 2.662 0.005
ENSG00000007376 E004 1195.12520 0.0001056934 1.126276e-01 3.035511e-01 16 785140 785327 188 - 2.994 2.986 -0.028
ENSG00000007376 E005 769.94619 0.0001707604 2.382184e-01 4.745729e-01 16 785328 785383 56 - 2.803 2.796 -0.023
ENSG00000007376 E006 515.03823 0.0001489324 4.058608e-01 6.329641e-01 16 785384 785387 4 - 2.626 2.622 -0.012
ENSG00000007376 E007 2670.94493 0.0013123355 2.056488e-03 1.743667e-02 16 785388 785967 580 - 3.285 3.343 0.193
ENSG00000007376 E008 606.74279 0.0001511354 2.413345e-03 1.976855e-02 16 785968 785982 15 - 2.639 2.708 0.231
ENSG00000007376 E009 1111.51430 0.0005097655 2.821388e-04 3.550211e-03 16 785983 786148 166 - 2.898 2.969 0.236
ENSG00000007376 E010 567.55844 0.0009554286 9.905993e-01 9.970280e-01 16 786149 786193 45 - 2.654 2.667 0.043
ENSG00000007376 E011 1016.49513 0.0002276745 3.880934e-02 1.516432e-01 16 786194 786377 184 - 2.932 2.914 -0.061
ENSG00000007376 E012 171.25912 0.0150791645 5.244780e-07 1.613851e-05 16 786378 786825 448 - 2.387 2.049 -1.129
ENSG00000007376 E013 48.14316 0.0326887309 8.576395e-04 8.754158e-03 16 786826 786826 1 - 1.849 1.502 -1.179
ENSG00000007376 E014 492.61008 0.0006608198 8.806014e-05 1.343392e-03 16 786827 786840 14 - 2.662 2.584 -0.261
ENSG00000007376 E015 679.56075 0.0005180559 4.252358e-05 7.249029e-04 16 786841 786928 88 - 2.795 2.726 -0.229
ENSG00000007376 E016 73.63889 0.0062612620 2.002833e-03 1.708666e-02 16 787068 787076 9 - 1.919 1.736 -0.617
ENSG00000007376 E017 727.15460 0.0001079306 1.365341e-02 7.297817e-02 16 787077 787179 103 - 2.795 2.768 -0.089
ENSG00000007376 E018 37.47041 0.0396440737 3.835627e-03 2.821771e-02 16 787180 787241 62 - 1.734 1.402 -1.135
ENSG00000007376 E019 18.61510 0.0500660203 5.423172e-02 1.896171e-01 16 787344 787353 10 - 1.399 1.138 -0.918
ENSG00000007376 E020 542.75744 0.0001623877 2.631744e-03 2.116049e-02 16 787354 787396 43 - 2.681 2.638 -0.146
ENSG00000007376 E021 629.04352 0.0001450882 8.690663e-01 9.354654e-01 16 787397 787477 81 - 2.703 2.713 0.032
ENSG00000007376 E022 438.38962 0.0002430326 5.642539e-01 7.462948e-01 16 787556 787603 48 - 2.534 2.560 0.085
ENSG00000007376 E023 422.08815 0.0005422737 4.311057e-02 1.628627e-01 16 787604 787645 42 - 2.489 2.549 0.200
ENSG00000007376 E024 442.59151 0.0079239822 3.441801e-02 1.400026e-01 16 787646 787744 99 - 2.468 2.572 0.347
ENSG00000007376 E025 76.51844 0.1239127336 1.448406e-01 3.547239e-01 16 787745 787981 237 - 1.967 1.739 -0.769
ENSG00000007376 E026 313.65702 1.1095292813 2.766365e-01 5.166188e-01 16 788256 788397 142 - 2.063 2.458 1.321