ENSG00000007341

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000467335 ENSG00000007341 HEK293_OSMI2_6hA HEK293_TMG_6hB ST7L protein_coding processed_transcript 27.68061 19.42921 33.02757 1.690586 0.8627069 0.7651382 7.198485 6.1644674 8.974735 0.09294822 0.61122417 0.5411612 0.27170833 0.32253333 0.27303333 -0.04950000 0.78767851 0.03981955 FALSE TRUE
ENST00000473206 ENSG00000007341 HEK293_OSMI2_6hA HEK293_TMG_6hB ST7L protein_coding processed_transcript 27.68061 19.42921 33.02757 1.690586 0.8627069 0.7651382 3.339517 3.5270362 2.135858 0.64604066 0.57957202 -0.7209864 0.12565000 0.18176667 0.06403333 -0.11773333 0.03993199 0.03981955 FALSE TRUE
ENST00000477332 ENSG00000007341 HEK293_OSMI2_6hA HEK293_TMG_6hB ST7L protein_coding processed_transcript 27.68061 19.42921 33.02757 1.690586 0.8627069 0.7651382 4.233602 3.5415207 3.252293 0.60725091 0.03240355 -0.1225507 0.16047500 0.18056667 0.09863333 -0.08193333 0.03981955 0.03981955 FALSE TRUE
ENST00000479436 ENSG00000007341 HEK293_OSMI2_6hA HEK293_TMG_6hB ST7L protein_coding processed_transcript 27.68061 19.42921 33.02757 1.690586 0.8627069 0.7651382 3.058051 0.8138414 3.723680 0.44852650 0.75760057 2.1801598 0.10186250 0.04260000 0.11173333 0.06913333 0.68237102 0.03981955 FALSE TRUE
MSTRG.1827.11 ENSG00000007341 HEK293_OSMI2_6hA HEK293_TMG_6hB ST7L protein_coding   27.68061 19.42921 33.02757 1.690586 0.8627069 0.7651382 1.217382 0.2437164 2.400508 0.24371640 0.71303187 3.2480488 0.03950833 0.01173333 0.07296667 0.06123333 0.22071057 0.03981955 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000007341 E001 0.1426347 0.0319692996 7.362978e-01   1 112523514 112523517 4 - 0.099 0.000 -8.957
ENSG00000007341 E002 56.9423805 0.8939234246 4.633255e-01 6.753586e-01 1 112523518 112525281 1764 - 1.694 1.832 0.466
ENSG00000007341 E003 20.0442661 0.5251166260 3.197594e-01 5.594881e-01 1 112525282 112525529 248 - 1.222 1.426 0.710
ENSG00000007341 E004 25.2057994 0.6535046640 5.512946e-01 7.372083e-01 1 112525530 112525875 346 - 1.389 1.439 0.173
ENSG00000007341 E005 6.5020413 0.2950399536 6.363917e-01 7.946030e-01 1 112525876 112525878 3 - 0.827 0.917 0.347
ENSG00000007341 E006 6.0741373 0.2753793769 5.090502e-01 7.072020e-01 1 112525879 112525882 4 - 0.779 0.916 0.534
ENSG00000007341 E007 18.1651456 0.5634487584 5.358982e-01 7.262611e-01 1 112525883 112525985 103 - 1.233 1.329 0.337
ENSG00000007341 E008 29.5565410 0.6965829252 5.028248e-01 7.027274e-01 1 112525986 112526111 126 - 1.435 1.532 0.331
ENSG00000007341 E009 1.1250361 0.0144256498 3.379137e-01   1 112526886 112526952 67 - 0.247 0.420 1.088
ENSG00000007341 E010 0.6897577 0.0561753642 5.710557e-01   1 112539159 112539275 117 - 0.248 0.148 -0.918
ENSG00000007341 E011 6.8023193 0.0682637981 2.634352e-01 5.026676e-01 1 112540779 112540872 94 - 0.958 0.766 -0.741
ENSG00000007341 E012 0.3206185 0.0274424043 3.538980e-01   1 112541790 112541793 4 - 0.179 0.000 -12.494
ENSG00000007341 E013 6.7022547 0.0102681872 9.073134e-03 5.414960e-02 1 112541794 112541950 157 - 0.985 0.630 -1.410
ENSG00000007341 E014 48.4996479 0.0075715592 8.711834e-02 2.584731e-01 1 112541951 112542090 140 - 1.724 1.620 -0.352
ENSG00000007341 E015 18.2518218 0.0252954634 4.206662e-01 6.441826e-01 1 112550601 112550693 93 - 1.309 1.233 -0.268
ENSG00000007341 E016 40.8343707 0.0125014567 1.450231e-02 7.624141e-02 1 112555868 112556018 151 - 1.676 1.496 -0.614
ENSG00000007341 E017 0.5540201 0.3188379412 3.024190e-01   1 112571275 112571351 77 - 0.099 0.335 2.181
ENSG00000007341 E018 1.1833707 0.0151218350 1.562992e-01   1 112572404 112572455 52 - 0.404 0.148 -1.914
ENSG00000007341 E019 2.0783180 0.0710924436 6.025361e-01 7.718966e-01 1 112575133 112575233 101 - 0.443 0.539 0.473
ENSG00000007341 E020 42.8914491 0.0050325509 3.098317e-04 3.830001e-03 1 112576986 112577088 103 - 1.707 1.481 -0.772
ENSG00000007341 E021 44.6843070 0.0007936003 1.418587e-04 2.002733e-03 1 112578345 112578417 73 - 1.719 1.515 -0.695
ENSG00000007341 E022 28.4883973 0.0014891807 4.763437e-04 5.462866e-03 1 112581992 112581995 4 - 1.535 1.295 -0.828
ENSG00000007341 E023 45.5977904 0.0009359516 3.248255e-05 5.775609e-04 1 112581996 112582106 111 - 1.730 1.504 -0.768
ENSG00000007341 E024 42.2925733 0.0011372209 4.363901e-04 5.093407e-03 1 112582375 112582472 98 - 1.693 1.498 -0.664
ENSG00000007341 E025 16.3737661 0.0020537710 4.038698e-02 1.557286e-01 1 112583972 112583974 3 - 1.294 1.121 -0.613
ENSG00000007341 E026 44.8347842 0.0037866607 8.607456e-04 8.778189e-03 1 112583975 112584126 152 - 1.723 1.529 -0.661
ENSG00000007341 E027 1.3066042 0.3211315653 5.538289e-01   1 112591482 112591524 43 - 0.404 0.261 -0.895
ENSG00000007341 E028 37.6546813 0.0013494559 7.590145e-04 7.933814e-03 1 112591525 112591603 79 - 1.648 1.451 -0.675
ENSG00000007341 E029 44.7073963 0.0008235209 2.014949e-04 2.691189e-03 1 112597971 112598021 51 - 1.719 1.520 -0.677
ENSG00000007341 E030 41.5979477 0.0029121077 2.582190e-02 1.147375e-01 1 112598022 112598086 65 - 1.667 1.541 -0.432
ENSG00000007341 E031 39.5223462 0.0011327904 2.969471e-03 2.321324e-02 1 112600794 112600848 55 - 1.655 1.487 -0.573
ENSG00000007341 E032 0.0000000       1 112601532 112601558 27 -      
ENSG00000007341 E033 40.0103710 0.0133651073 2.825234e-03 2.234490e-02 1 112607104 112607240 137 - 1.485 1.727 0.825
ENSG00000007341 E034 54.3080471 0.0007542069 5.840265e-14 7.611752e-12 1 112607241 112607454 214 - 1.547 1.916 1.249
ENSG00000007341 E035 38.3716243 0.0009641390 9.357730e-17 1.795659e-14 1 112607455 112607597 143 - 1.331 1.815 1.653
ENSG00000007341 E036 0.2617363 0.1379716688 1.294176e-01   1 112610455 112610458 4 - 0.000 0.255 11.752
ENSG00000007341 E037 2.2595598 0.1047613166 7.679350e-01 8.773573e-01 1 112610459 112610487 29 - 0.485 0.536 0.247
ENSG00000007341 E038 45.6937288 0.0008499953 3.202501e-03 2.461677e-02 1 112610488 112610615 128 - 1.586 1.748 0.548
ENSG00000007341 E039 40.0698522 0.0009329744 1.534627e-02 7.937833e-02 1 112610616 112610657 42 - 1.541 1.683 0.485
ENSG00000007341 E040 51.0901446 0.0025314863 2.413163e-02 1.094614e-01 1 112610658 112610690 33 - 1.646 1.774 0.434
ENSG00000007341 E041 81.5340492 0.0006967302 7.384135e-04 7.769011e-03 1 112610691 112610840 150 - 1.844 1.985 0.476
ENSG00000007341 E042 235.4250127 0.0003344489 2.940309e-01 5.346446e-01 1 112610841 112611003 163 - 2.349 2.382 0.108
ENSG00000007341 E043 129.1394603 0.0008225672 4.320579e-01 6.527862e-01 1 112616813 112616844 32 - 2.110 2.093 -0.058
ENSG00000007341 E044 124.3050973 0.0005114375 2.520669e-01 4.901330e-01 1 112616845 112616895 51 - 2.069 2.114 0.151
ENSG00000007341 E045 4.7220061 0.0271484738 6.493643e-01 8.030308e-01 1 112616896 112617286 391 - 0.727 0.798 0.286
ENSG00000007341 E046 5.7528033 0.1893224602 8.330284e-01 9.154747e-01 1 112618007 112618217 211 - 0.798 0.834 0.141
ENSG00000007341 E047 5.1219302 0.0062925798 3.853876e-01 6.167604e-01 1 112618247 112618369 123 - 0.728 0.851 0.488
ENSG00000007341 E048 2.2998487 0.0314745326 1.927135e-01 4.203985e-01 1 112618784 112618908 125 - 0.581 0.348 -1.198
ENSG00000007341 E049 140.9158957 0.0094795540 3.631969e-01 5.982819e-01 1 112618909 112619139 231 - 2.119 2.174 0.184
ENSG00000007341 E050 5.6474646 0.1581224089 5.389540e-01 7.282874e-01 1 112619140 112619196 57 - 0.863 0.705 -0.632
ENSG00000007341 E051 10.9351957 0.2842022291 9.803714e-01 9.919492e-01 1 112619197 112619396 200 - 1.123 0.946 -0.649
ENSG00000007341 E052 11.1542060 0.3806499117 6.194778e-01 7.834961e-01 1 112619397 112619643 247 - 1.168 0.850 -1.176
ENSG00000007341 E053 8.0724681 0.1419153493 2.388874e-01 4.753191e-01 1 112619644 112619796 153 - 1.030 0.747 -1.083
ENSG00000007341 E054 2.1949643 0.0511673999 9.659818e-01 9.848764e-01 1 112619910 112620825 916 - 0.486 0.483 -0.016