ENSG00000007264

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310132 ENSG00000007264 HEK293_OSMI2_6hA HEK293_TMG_6hB MATK protein_coding protein_coding 44.80419 67.26458 20.12375 14.93389 1.100494 -1.740445 20.207227 31.146373 12.2150246 7.6333510 0.7272975 -1.349690 0.46047500 0.45586667 0.60743333 0.15156667 0.04660291 0.04660291 FALSE TRUE
ENST00000395040 ENSG00000007264 HEK293_OSMI2_6hA HEK293_TMG_6hB MATK protein_coding protein_coding 44.80419 67.26458 20.12375 14.93389 1.100494 -1.740445 8.209056 13.901695 0.7818461 2.6031657 0.7818461 -4.134934 0.16892083 0.21276667 0.04336667 -0.16940000 0.18010894 0.04660291 FALSE TRUE
MSTRG.16185.15 ENSG00000007264 HEK293_OSMI2_6hA HEK293_TMG_6hB MATK protein_coding   44.80419 67.26458 20.12375 14.93389 1.100494 -1.740445 4.132433 5.579499 2.2400766 0.7202251 0.4270805 -1.312745 0.10281250 0.08773333 0.10966667 0.02193333 0.79485638 0.04660291 FALSE TRUE
MSTRG.16185.17 ENSG00000007264 HEK293_OSMI2_6hA HEK293_TMG_6hB MATK protein_coding   44.80419 67.26458 20.12375 14.93389 1.100494 -1.740445 2.940389 6.427973 0.7892820 1.9783596 0.1303854 -3.009830 0.05891667 0.09040000 0.04006667 -0.05033333 0.14278905 0.04660291 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000007264 E001 0.0000000       19 3777970 3777972 3 -      
ENSG00000007264 E002 1.5106757 0.0143474198 4.208274e-01 6.443204e-01 19 3777973 3777974 2 - 0.218 0.386 1.134
ENSG00000007264 E003 5.0995314 0.0118172635 5.490423e-01 7.356374e-01 19 3777975 3777976 2 - 0.630 0.735 0.444
ENSG00000007264 E004 7.9988170 0.0174512444 3.299702e-01 5.689276e-01 19 3777977 3777983 7 - 0.746 0.907 0.632
ENSG00000007264 E005 15.4217508 0.0812294587 9.949771e-01 9.990444e-01 19 3777984 3777985 2 - 1.110 1.125 0.057
ENSG00000007264 E006 27.2944099 0.0016414206 2.029135e-01 4.332443e-01 19 3777986 3777994 9 - 1.270 1.382 0.392
ENSG00000007264 E007 347.4763465 0.0002534771 3.951598e-07 1.259284e-05 19 3777995 3778422 428 - 2.340 2.469 0.432
ENSG00000007264 E008 248.9780170 0.0002070655 5.919647e-02 2.009893e-01 19 3778509 3778592 84 - 2.257 2.311 0.181
ENSG00000007264 E009 170.3973011 0.0002857698 3.044803e-01 5.450610e-01 19 3778593 3778595 3 - 2.110 2.145 0.118
ENSG00000007264 E010 340.1070993 0.0001660959 5.585804e-01 7.422412e-01 19 3778992 3779132 141 - 2.447 2.433 -0.045
ENSG00000007264 E011 241.2112123 0.0003221752 7.762677e-02 2.400672e-01 19 3779133 3779187 55 - 2.325 2.275 -0.169
ENSG00000007264 E012 171.6827549 0.0002984922 4.650813e-01 6.766035e-01 19 3779378 3779388 11 - 2.160 2.135 -0.081
ENSG00000007264 E013 256.8458555 0.0002161892 6.909662e-02 2.229691e-01 19 3779389 3779451 63 - 2.354 2.305 -0.163
ENSG00000007264 E014 162.0670551 0.0033585758 1.100822e-01 2.991453e-01 19 3779533 3779541 9 - 2.175 2.098 -0.259
ENSG00000007264 E015 289.9545681 0.0023180430 4.904026e-02 1.772893e-01 19 3779542 3779617 76 - 2.423 2.348 -0.251
ENSG00000007264 E016 321.0583958 0.0004717235 1.948562e-02 9.414509e-02 19 3779698 3779788 91 - 2.459 2.398 -0.203
ENSG00000007264 E017 160.9112245 0.0005714308 5.733185e-02 1.967956e-01 19 3779789 3779797 9 - 2.167 2.101 -0.223
ENSG00000007264 E018 264.0317071 0.0004062230 1.644635e-04 2.270891e-03 19 3781607 3781672 66 - 2.406 2.303 -0.342
ENSG00000007264 E019 22.1005045 0.0981297384 5.796316e-02 1.982015e-01 19 3782292 3782426 135 - 1.509 1.180 -1.148
ENSG00000007264 E020 74.2777784 0.0027716224 3.283489e-01 5.673805e-01 19 3782427 3782671 245 - 1.829 1.773 -0.188
ENSG00000007264 E021 41.9926373 0.0147897000 1.788418e-01 4.024082e-01 19 3782787 3782817 31 - 1.432 1.566 0.461
ENSG00000007264 E022 68.1906345 0.0180481687 1.170917e-01 3.109977e-01 19 3782818 3782937 120 - 1.621 1.769 0.501
ENSG00000007264 E023 328.4890727 0.0003519545 1.134967e-01 3.049788e-01 19 3783126 3783219 94 - 2.451 2.412 -0.132
ENSG00000007264 E024 16.1741947 0.0021538382 5.680217e-01 7.488000e-01 19 3783220 3783297 78 - 1.186 1.129 -0.204
ENSG00000007264 E025 250.3848037 0.0002445045 5.807102e-01 7.576508e-01 19 3783814 3783871 58 - 2.315 2.299 -0.051
ENSG00000007264 E026 326.0952311 0.0009587766 1.657670e-01 3.848348e-01 19 3783872 3784020 149 - 2.384 2.422 0.127
ENSG00000007264 E027 142.8421824 0.0005375619 1.007707e-01 2.831589e-01 19 3784021 3784033 13 - 2.009 2.071 0.210
ENSG00000007264 E028 301.7514327 0.0006299038 5.795952e-02 1.981930e-01 19 3784124 3784239 116 - 2.341 2.392 0.172
ENSG00000007264 E029 298.8550278 0.0011353823 1.743956e-02 8.706861e-02 19 3784338 3784451 114 - 2.320 2.392 0.241
ENSG00000007264 E030 6.0158820 0.0050360112 6.273253e-03 4.106475e-02 19 3784452 3784573 122 - 1.032 0.669 -1.413
ENSG00000007264 E031 195.5499214 0.0018713785 8.375586e-03 5.104755e-02 19 3784825 3784884 60 - 2.110 2.214 0.347
ENSG00000007264 E032 98.9723686 0.0046351019 4.511977e-01 6.665002e-01 19 3785064 3785096 33 - 1.930 1.895 -0.118
ENSG00000007264 E033 157.6387200 0.0042447312 5.962675e-01 7.678362e-01 19 3785097 3785246 150 - 2.118 2.098 -0.066
ENSG00000007264 E034 78.6892687 0.0006676187 2.729075e-01 5.127365e-01 19 3785247 3785279 33 - 1.850 1.798 -0.174
ENSG00000007264 E035 50.2286289 0.0078524696 1.204559e-01 3.165611e-01 19 3785280 3785286 7 - 1.698 1.594 -0.353
ENSG00000007264 E036 3.1223551 0.1991601235 4.116561e-01 6.372742e-01 19 3785613 3786024 412 - 0.690 0.492 -0.886
ENSG00000007264 E037 4.9636691 0.0063163049 9.560058e-01 9.799117e-01 19 3786025 3786168 144 - 0.691 0.698 0.030
ENSG00000007264 E038 179.0190746 0.0012000657 3.799641e-04 4.539016e-03 19 3786169 3786413 245 - 2.046 2.184 0.464
ENSG00000007264 E039 0.0000000       19 3787460 3787715 256 -      
ENSG00000007264 E040 0.0000000       19 3789273 3789404 132 -      
ENSG00000007264 E041 0.0000000       19 3793074 3793129 56 -      
ENSG00000007264 E042 0.0000000       19 3793130 3793398 269 -      
ENSG00000007264 E043 0.0000000       19 3793399 3793401 3 -      
ENSG00000007264 E044 0.1308682 0.0326491905 1.000000e+00   19 3801532 3801686 155 - 0.001 0.064 6.379
ENSG00000007264 E045 0.0000000       19 3801687 3801812 126 -      
ENSG00000007264 E046 0.0000000       19 3801895 3802129 235 -