ENSG00000006695

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261643 ENSG00000006695 HEK293_OSMI2_6hA HEK293_TMG_6hB COX10 protein_coding protein_coding 12.87451 15.19933 13.55895 1.962703 1.072584 -0.1646478 9.4908977 12.7432395 7.185672 2.4352479 0.1218275 -0.8256625 0.72848333 0.82270000 0.5359333 -0.2867667 0.04799413 0.04799413 FALSE TRUE
MSTRG.13698.6 ENSG00000006695 HEK293_OSMI2_6hA HEK293_TMG_6hB COX10 protein_coding   12.87451 15.19933 13.55895 1.962703 1.072584 -0.1646478 1.0275573 0.5446924 2.173100 0.5446924 1.2104006 1.9766181 0.08392500 0.04800000 0.1568667 0.1088667 0.63283948 0.04799413 FALSE TRUE
MSTRG.13698.7 ENSG00000006695 HEK293_OSMI2_6hA HEK293_TMG_6hB COX10 protein_coding   12.87451 15.19933 13.55895 1.962703 1.072584 -0.1646478 0.7863691 0.5952216 1.875211 0.2376861 1.6066112 1.6391905 0.06204167 0.03643333 0.1368667 0.1004333 1.00000000 0.04799413 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000006695 E001 0.4231520 0.0893241325 9.223076e-01   17 14069490 14069495 6 + 0.151 0.175 0.260
ENSG00000006695 E002 0.4231520 0.0893241325 9.223076e-01   17 14069496 14069503 8 + 0.151 0.175 0.260
ENSG00000006695 E003 2.9839291 0.0628961350 2.531954e-01 4.914215e-01 17 14069504 14069519 16 + 0.712 0.510 -0.892
ENSG00000006695 E004 46.0326751 0.0009371362 8.512786e-02 2.548418e-01 17 14069520 14069603 84 + 1.712 1.623 -0.304
ENSG00000006695 E005 53.6244489 0.0061222587 3.564292e-02 1.433043e-01 17 14069604 14069648 45 + 1.800 1.672 -0.434
ENSG00000006695 E006 105.9490562 0.0068439024 3.873198e-02 1.514420e-01 17 14074323 14074456 134 + 2.078 1.970 -0.359
ENSG00000006695 E007 188.7835211 0.0003320211 1.204047e-03 1.146481e-02 17 14076735 14077056 322 + 2.313 2.234 -0.266
ENSG00000006695 E008 2.2490473 0.0357902344 1.009769e-01 2.835584e-01 17 14077057 14077322 266 + 0.674 0.397 -1.316
ENSG00000006695 E009 87.5207109 0.0006445275 5.709207e-01 7.509465e-01 17 14102118 14102242 125 + 1.948 1.928 -0.067
ENSG00000006695 E010 83.7925210 0.0027824587 7.543290e-01 8.693020e-01 17 14159877 14159947 71 + 1.905 1.921 0.054
ENSG00000006695 E011 1.0764452 0.0616531355 5.751786e-01   17 14182021 14182130 110 + 0.351 0.246 -0.710
ENSG00000006695 E012 103.9246624 0.0091036876 1.671782e-01 3.867944e-01 17 14191989 14192221 233 + 1.958 2.033 0.252
ENSG00000006695 E013 0.5171231 0.9734029409 5.407886e-01   17 14202109 14202169 61 + 0.000 0.251 9.554
ENSG00000006695 E014 129.7625897 0.0006301843 3.934778e-04 4.667290e-03 17 14206810 14207268 459 + 2.026 2.144 0.394
ENSG00000006695 E015 437.3228296 0.0007479300 9.597161e-06 2.023112e-04 17 14207269 14208553 1285 + 2.575 2.654 0.262
ENSG00000006695 E016 52.0475657 0.0043652531 2.789527e-02 1.209866e-01 17 14208554 14208779 226 + 1.619 1.753 0.452
ENSG00000006695 E017 1.5364037 0.3914240156 2.774298e-01 5.174799e-01 17 14208780 14208790 11 + 0.152 0.466 2.196
ENSG00000006695 E018 6.5706438 0.0050132523 5.065620e-08 2.017019e-06 17 14209509 14209965 457 + 1.167 0.478 -2.767
ENSG00000006695 E019 0.5470056 0.2416057046 6.630943e-01   17 14210468 14210487 20 + 0.259 0.173 -0.742
ENSG00000006695 E020 0.7367559 0.0383869457 6.180243e-02   17 14210488 14210565 78 + 0.424 0.097 -2.722
ENSG00000006695 E021 5.9022853 0.0159833251 3.835527e-03 2.821771e-02 17 14211288 14211508 221 + 1.023 0.631 -1.542
ENSG00000006695 E022 4.6352348 0.0065371533 4.343271e-04 5.072815e-03 17 14215810 14215937 128 + 0.968 0.479 -2.043
ENSG00000006695 E023 15.5469854 0.0301922624 2.256517e-03 1.877829e-02 17 14216685 14217665 981 + 1.392 1.035 -1.266
ENSG00000006695 E024 3.3376342 0.0073096907 2.265331e-03 1.882949e-02 17 14217666 14217922 257 + 0.858 0.399 -2.043
ENSG00000006695 E025 7.6850156 0.1095207662 8.053635e-01 8.993527e-01 17 14230403 14231736 1334 + 0.946 0.911 -0.133