ENSG00000006118

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000005286 ENSG00000006118 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM132A protein_coding protein_coding 30.66439 43.55655 21.66318 3.592654 0.5592902 -1.00731 10.756763 15.167693 6.869858 2.5754813 0.4185480 -1.1415018 0.34414583 0.3436333 0.3165333 -0.02710000 0.90943424 0.0122959 FALSE TRUE
ENST00000453848 ENSG00000006118 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM132A protein_coding protein_coding 30.66439 43.55655 21.66318 3.592654 0.5592902 -1.00731 7.435632 12.930717 1.928018 2.7134369 0.3644659 -2.7392637 0.22428333 0.2922000 0.0890000 -0.20320000 0.01229590 0.0122959 FALSE TRUE
ENST00000540112 ENSG00000006118 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM132A protein_coding protein_coding 30.66439 43.55655 21.66318 3.592654 0.5592902 -1.00731 4.568286 5.439095 3.679355 1.0660405 0.1978835 -0.5626480 0.15186667 0.1288333 0.1696000 0.04076667 0.73855748 0.0122959 FALSE TRUE
MSTRG.5558.14 ENSG00000006118 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM132A protein_coding   30.66439 43.55655 21.66318 3.592654 0.5592902 -1.00731 1.672314 1.926330 2.223652 0.2631156 0.3145454 0.2060794 0.06314583 0.0454000 0.1022000 0.05680000 0.09606598 0.0122959   TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000006118 E001 0.2617363 0.0768805926 7.748061e-01   11 60924460 60924462 3 + 0.000 0.133 8.322
ENSG00000006118 E002 0.7685209 0.0181367714 4.516041e-01   11 60924463 60924469 7 + 0.332 0.188 -1.083
ENSG00000006118 E003 1.6248558 0.0110546574 7.012584e-01 8.364152e-01 11 60924470 60924480 11 + 0.435 0.355 -0.445
ENSG00000006118 E004 2.9162291 0.0082611333 7.324306e-01 8.556594e-01 11 60924481 60924482 2 + 0.519 0.569 0.235
ENSG00000006118 E005 3.7132045 0.0539361819 7.435942e-01 8.627056e-01 11 60924483 60924486 4 + 0.588 0.655 0.293
ENSG00000006118 E006 4.5942898 0.0074002903 3.162204e-01 5.562559e-01 11 60924487 60924491 5 + 0.588 0.741 0.649
ENSG00000006118 E007 5.8201239 0.0048490389 1.034502e-01 2.879658e-01 11 60924492 60924497 6 + 0.588 0.831 1.008
ENSG00000006118 E008 7.2055409 0.0045198954 1.331848e-01 3.368005e-01 11 60924498 60924501 4 + 0.701 0.905 0.806
ENSG00000006118 E009 17.0042157 0.0176290907 3.006697e-02 1.275369e-01 11 60924502 60924543 42 + 0.984 1.242 0.928
ENSG00000006118 E010 92.5584369 0.0012295203 6.096778e-01 7.767008e-01 11 60924544 60924733 190 + 1.899 1.907 0.028
ENSG00000006118 E011 23.8173798 0.2188779925 8.464309e-02 2.540328e-01 11 60925208 60925703 496 + 1.592 1.198 -1.366
ENSG00000006118 E012 31.3222376 0.0518379334 1.415013e-05 2.833078e-04 11 60925704 60926084 381 + 1.788 1.240 -1.883
ENSG00000006118 E013 21.7211556 0.0128049567 1.551978e-05 3.071098e-04 11 60926579 60926721 143 + 1.564 1.157 -1.417
ENSG00000006118 E014 28.6010547 0.1017159506 7.994664e-02 2.447148e-01 11 60926832 60927048 217 + 1.617 1.309 -1.062
ENSG00000006118 E015 10.9061140 0.1358859430 7.482282e-02 2.344527e-01 11 60927049 60927067 19 + 1.247 0.901 -1.260
ENSG00000006118 E016 21.4572740 0.0998201408 9.026265e-02 2.642465e-01 11 60927068 60927203 136 + 1.478 1.201 -0.966
ENSG00000006118 E017 183.2541027 0.0002582690 4.651936e-02 1.713418e-01 11 60927204 60927358 155 + 2.255 2.182 -0.245
ENSG00000006118 E018 143.8435284 0.0003723828 6.931468e-01 8.311497e-01 11 60927359 60927418 60 + 2.117 2.089 -0.094
ENSG00000006118 E019 265.4931526 0.0002391184 5.680277e-01 7.488000e-01 11 60927641 60927859 219 + 2.381 2.351 -0.098
ENSG00000006118 E020 308.8557720 0.0011024372 7.889758e-01 8.898660e-01 11 60928629 60928960 332 + 2.440 2.416 -0.080
ENSG00000006118 E021 179.5927863 0.0007309441 3.563769e-01 5.928608e-01 11 60930510 60930659 150 + 2.223 2.177 -0.153
ENSG00000006118 E022 36.2368119 0.0117484019 1.470024e-01 3.580048e-01 11 60931686 60931688 3 + 1.604 1.470 -0.457
ENSG00000006118 E023 144.9873317 0.0047435298 7.960893e-02 2.440561e-01 11 60931689 60931754 66 + 2.169 2.068 -0.337
ENSG00000006118 E024 219.5975242 0.0027716733 1.411657e-01 3.492546e-01 11 60931755 60931884 130 + 2.328 2.256 -0.240
ENSG00000006118 E025 7.6938788 0.2075778333 2.629705e-01 5.021773e-01 11 60931885 60931983 99 + 1.059 0.795 -0.998
ENSG00000006118 E026 175.2542870 0.0004786722 3.977179e-01 6.265575e-01 11 60931984 60932127 144 + 2.171 2.182 0.039
ENSG00000006118 E027 52.8020218 0.1106494486 2.044835e-02 9.748742e-02 11 60932128 60933541 1414 + 1.915 1.537 -1.280
ENSG00000006118 E028 184.1441449 0.0003730360 4.505902e-07 1.412601e-05 11 60933542 60933744 203 + 2.083 2.233 0.499
ENSG00000006118 E029 22.7946708 0.0386636170 1.570481e-01 3.723365e-01 11 60933745 60933996 252 + 1.441 1.252 -0.656
ENSG00000006118 E030 21.9960184 0.0361686522 2.177171e-02 1.018326e-01 11 60933997 60934205 209 + 1.491 1.207 -0.988
ENSG00000006118 E031 15.7810567 0.0795912262 4.071528e-02 1.565830e-01 11 60934206 60934337 132 + 1.381 1.057 -1.146
ENSG00000006118 E032 10.4418542 0.0170556015 2.270754e-01 4.618415e-01 11 60934338 60934487 150 + 1.116 0.952 -0.600
ENSG00000006118 E033 104.6753507 0.0038914174 5.789346e-10 3.521362e-08 11 60934488 60934642 155 + 1.683 2.014 1.115
ENSG00000006118 E034 144.7108209 0.0034180792 3.910796e-02 1.524558e-01 11 60934643 60934764 122 + 2.036 2.115 0.263
ENSG00000006118 E035 166.8913795 0.0011860763 8.567668e-01 9.287138e-01 11 60935252 60935317 66 + 2.176 2.155 -0.070
ENSG00000006118 E036 217.2318967 0.0009508489 9.704799e-01 9.871005e-01 11 60935318 60935443 126 + 2.286 2.270 -0.053
ENSG00000006118 E037 57.4944933 0.0675773234 3.877482e-02 1.515642e-01 11 60935444 60935863 420 + 1.888 1.617 -0.917
ENSG00000006118 E038 220.3555334 0.0002381073 5.958761e-02 2.018262e-01 11 60935864 60936016 153 + 2.249 2.287 0.125
ENSG00000006118 E039 642.2796695 0.0007580832 1.712195e-07 6.013858e-06 11 60936017 60936746 730 + 2.674 2.759 0.283
ENSG00000006118 E040 339.1766160 0.0068924813 8.417037e-02 2.531273e-01 11 60936747 60937159 413 + 2.420 2.474 0.180