ENSG00000005893

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000200639 ENSG00000005893 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMP2 protein_coding protein_coding 57.21664 24.75636 86.2316 5.656213 2.599104 1.800002 3.323737 1.557102 4.491187 0.4508509 0.1408493 1.522206 0.0595500 0.0603000 0.05216667 -0.008133333 8.335936e-01 7.691464e-05 FALSE TRUE
ENST00000371335 ENSG00000005893 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMP2 protein_coding protein_coding 57.21664 24.75636 86.2316 5.656213 2.599104 1.800002 18.457749 6.333395 28.300388 1.7907056 0.7514232 2.158005 0.3166000 0.2471333 0.32846667 0.081333333 3.530824e-01 7.691464e-05 FALSE TRUE
MSTRG.34818.4 ENSG00000005893 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMP2 protein_coding   57.21664 24.75636 86.2316 5.656213 2.599104 1.800002 18.433407 11.962929 25.331586 2.7083746 2.2038812 1.081731 0.3964833 0.4839667 0.29283333 -0.191133333 7.691464e-05 7.691464e-05 FALSE TRUE
MSTRG.34818.6 ENSG00000005893 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMP2 protein_coding   57.21664 24.75636 86.2316 5.656213 2.599104 1.800002 16.597063 4.843707 27.752086 0.8391032 0.2912854 2.515957 0.2199958 0.2067333 0.32236667 0.115633333 1.576458e-01 7.691464e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000005893 E001 108.347389 0.0081272905 1.127928e-01 3.038131e-01 X 120426148 120427826 1679 - 1.957 2.046 0.298
ENSG00000005893 E002 54.257106 0.0008868852 8.686733e-02 2.579977e-01 X 120427827 120428626 800 - 1.665 1.750 0.289
ENSG00000005893 E003 218.949090 0.0004302249 1.858056e-02 9.100736e-02 X 120428627 120431247 2621 - 2.273 2.331 0.194
ENSG00000005893 E004 235.867880 0.0026750806 1.144836e-16 2.172284e-14 X 120431248 120431462 215 - 2.231 2.503 0.908
ENSG00000005893 E005 3.046685 0.1236348277 2.754664e-01 5.155333e-01 X 120434009 120434042 34 - 0.494 0.691 0.885
ENSG00000005893 E006 1050.228640 0.0023419481 1.055970e-06 2.980356e-05 X 120436494 120439075 2582 - 2.994 2.875 -0.396
ENSG00000005893 E007 263.446904 0.0001917517 3.863834e-25 1.994431e-22 X 120439076 120439293 218 - 2.428 2.131 -0.993
ENSG00000005893 E008 493.685597 0.0001929441 1.376239e-04 1.952034e-03 X 120441730 120441894 165 - 2.624 2.684 0.201
ENSG00000005893 E009 334.186036 0.0002283701 9.298740e-03 5.507987e-02 X 120442599 120442662 64 - 2.457 2.506 0.165
ENSG00000005893 E010 419.692239 0.0013731612 9.645716e-03 5.659231e-02 X 120446305 120446427 123 - 2.554 2.606 0.174
ENSG00000005893 E011 540.417847 0.0040334770 8.024628e-01 8.977291e-01 X 120447841 120448025 185 - 2.681 2.673 -0.028
ENSG00000005893 E012 480.358425 0.0020106773 4.414621e-01 6.597185e-01 X 120448970 120449128 159 - 2.636 2.608 -0.095
ENSG00000005893 E013 527.309463 0.0001564245 9.892999e-02 2.799211e-01 X 120455357 120455570 214 - 2.678 2.642 -0.121
ENSG00000005893 E014 306.743166 0.0001666654 5.560992e-01 7.405716e-01 X 120456651 120456769 119 - 2.438 2.418 -0.069
ENSG00000005893 E015 1.711715 0.4930473210 5.623935e-01 7.449884e-01 X 120468902 120469105 204 - 0.327 0.599 1.404
ENSG00000005893 E016 232.514762 0.0002325315 2.107448e-01 4.426851e-01 X 120469106 120469365 260 - 2.308 2.334 0.087