ENSG00000005884

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000007722 ENSG00000005884 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA3 protein_coding protein_coding 2.161578 2.628813 1.068171 0.2715474 0.07559253 -1.291304 0.13323775 0.000000 0.39563625 0.000000000 0.04038094 5.3421147 0.08950833 0.0000 0.3716 0.3716 9.064701e-11 9.064701e-11 FALSE TRUE
ENST00000320031 ENSG00000005884 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA3 protein_coding protein_coding 2.161578 2.628813 1.068171 0.2715474 0.07559253 -1.291304 1.20348471 2.149120 0.30480682 0.173188328 0.01782944 -2.7779048 0.55655833 0.8212 0.2859 -0.5353 1.447941e-08 9.064701e-11 FALSE TRUE
ENST00000506437 ENSG00000005884 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA3 protein_coding retained_intron 2.161578 2.628813 1.068171 0.2715474 0.07559253 -1.291304 0.17952105 0.168566 0.21778453 0.009581891 0.02475338 0.3512122 0.09489583 0.0660 0.2033 0.1373 6.247415e-02 9.064701e-11 FALSE TRUE
ENST00000510809 ENSG00000005884 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA3 protein_coding nonsense_mediated_decay 2.161578 2.628813 1.068171 0.2715474 0.07559253 -1.291304 0.03673907 0.000000 0.05441148 0.000000000 0.05441148 2.6873179 0.02041250 0.0000 0.0511 0.0511 7.223644e-01 9.064701e-11   FALSE
ENST00000514834 ENSG00000005884 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA3 protein_coding retained_intron 2.161578 2.628813 1.068171 0.2715474 0.07559253 -1.291304 0.27252993 0.000000 0.00000000 0.000000000 0.00000000 0.0000000 0.09505417 0.0000 0.0000 0.0000   9.064701e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000005884 E001 0.4054685 0.7020504297 1.0000000000   17 50055968 50056016 49 + 0.000 0.133 9.710
ENSG00000005884 E002 1.8628218 0.0771542452 0.7860436007 0.888119986 17 50056068 50056109 42 + 0.457 0.395 -0.330
ENSG00000005884 E003 8.1687812 0.0039623619 0.3516620670 0.588766054 17 50056110 50056437 328 + 0.779 0.910 0.508
ENSG00000005884 E004 1.4332001 0.1494742111 0.1161892031 0.309486151 17 50056438 50056439 2 + 0.000 0.414 14.335
ENSG00000005884 E005 3.2830150 0.1128244860 0.0119553391 0.066264942 17 50056440 50056486 47 + 0.000 0.655 15.287
ENSG00000005884 E006 7.7129702 0.0150975210 0.0734322487 0.231655609 17 50056487 50056645 159 + 0.616 0.903 1.159
ENSG00000005884 E007 0.2617363 0.1107171983 1.0000000000   17 50063538 50064076 539 + 0.000 0.123 12.370
ENSG00000005884 E008 10.2078377 0.0037734219 0.3454996728 0.583100567 17 50064077 50064204 128 + 0.862 0.984 0.462
ENSG00000005884 E009 0.0000000       17 50064205 50064527 323 +      
ENSG00000005884 E010 9.0397181 0.0041453462 0.8638865106 0.932557337 17 50064528 50064607 80 + 0.931 0.910 -0.077
ENSG00000005884 E011 0.4646582 0.0217681645 0.5937626997   17 50064608 50066032 1425 + 0.211 0.124 -0.920
ENSG00000005884 E012 17.4683779 0.0026439204 0.0194277171 0.093938908 17 50068056 50068305 250 + 1.336 1.128 -0.735
ENSG00000005884 E013 9.1451729 0.0234153119 0.0597129262 0.202137426 17 50070844 50070872 29 + 1.109 0.856 -0.940
ENSG00000005884 E014 10.8179865 0.0300481757 0.3421392286 0.579854304 17 50070873 50070930 58 + 1.088 0.955 -0.486
ENSG00000005884 E015 13.4210005 0.0024262164 0.3647407323 0.599698946 17 50071311 50071518 208 + 1.151 1.059 -0.334
ENSG00000005884 E016 0.0000000       17 50071740 50071985 246 +      
ENSG00000005884 E017 11.5976327 0.0058444363 0.0518149830 0.184029611 17 50071986 50072159 174 + 1.188 0.982 -0.746
ENSG00000005884 E018 7.6400498 0.0042578402 0.2025737374 0.432801749 17 50072160 50072182 23 + 0.990 0.832 -0.600
ENSG00000005884 E019 9.0987674 0.0033713173 0.1921025059 0.419513424 17 50073916 50074004 89 + 0.779 0.960 0.694
ENSG00000005884 E020 11.4809750 0.0100391537 0.4720728628 0.681597548 17 50074144 50074280 137 + 0.931 1.021 0.336
ENSG00000005884 E021 0.1779838 0.0357704085 0.1149781611   17 50074281 50074292 12 + 0.212 0.000 -14.825
ENSG00000005884 E022 9.4520264 0.0037625765 0.7732977732 0.880658180 17 50074448 50074534 87 + 0.962 0.928 -0.127
ENSG00000005884 E023 5.5848711 0.0065187837 0.7094147516 0.841422974 17 50075459 50075459 1 + 0.780 0.726 -0.218
ENSG00000005884 E024 10.6495258 0.0086839853 0.6443274794 0.799672780 17 50075460 50075526 67 + 0.931 0.991 0.225
ENSG00000005884 E025 1.9528487 0.0102748459 0.7147953217 0.844783884 17 50075527 50075598 72 + 0.353 0.425 0.405
ENSG00000005884 E026 12.8563457 0.0030108689 0.1139426902 0.305678959 17 50075599 50075735 137 + 0.898 1.089 0.710
ENSG00000005884 E027 16.8298088 0.0022143757 0.1325815454 0.335868931 17 50076326 50076475 150 + 1.043 1.202 0.572
ENSG00000005884 E028 10.0035782 0.0035692041 0.3279270315 0.566970590 17 50076584 50076624 41 + 0.862 0.990 0.485
ENSG00000005884 E029 10.5326603 0.0122664764 0.4260385570 0.648040645 17 50076625 50076681 57 + 0.898 1.009 0.415
ENSG00000005884 E030 0.4812263 0.0217681645 0.5935884066   17 50076682 50076973 292 + 0.212 0.124 -0.921
ENSG00000005884 E031 14.1565504 0.0022851836 0.5018302871 0.702125991 17 50076974 50077121 148 + 1.043 1.117 0.270
ENSG00000005884 E032 0.1779838 0.0357704085 0.1149781611   17 50077122 50077378 257 + 0.212 0.000 -14.825
ENSG00000005884 E033 7.9004105 0.0039780808 0.8847634417 0.943782164 17 50077379 50077399 21 + 0.861 0.882 0.080
ENSG00000005884 E034 9.3217242 0.0036266509 0.6805992337 0.823136950 17 50077400 50077447 48 + 0.897 0.952 0.205
ENSG00000005884 E035 0.2027342 0.0461823244 1.0000000000   17 50078004 50078045 42 + 0.000 0.067 11.581
ENSG00000005884 E036 10.9307292 0.0042546787 0.5406997724 0.729521492 17 50078046 50078125 80 + 0.931 1.006 0.280
ENSG00000005884 E037 10.6910685 0.0046144867 0.3581434671 0.594322797 17 50078207 50078284 78 + 1.067 0.961 -0.389
ENSG00000005884 E038 10.3441018 0.0238107803 0.9021001505 0.952939133 17 50078824 50078926 103 + 0.990 0.979 -0.038
ENSG00000005884 E039 0.0000000       17 50078927 50079016 90 +      
ENSG00000005884 E040 18.0753830 0.0024050806 0.5351383669 0.725688845 17 50079076 50079258 183 + 1.152 1.215 0.225
ENSG00000005884 E041 16.4570983 0.0021306123 0.5793125756 0.756671301 17 50079435 50079557 123 + 1.111 1.169 0.208
ENSG00000005884 E042 10.5584740 0.0030903823 0.5046180606 0.704040034 17 50080262 50080316 55 + 1.043 0.968 -0.276
ENSG00000005884 E043 14.1111384 0.0025427219 0.1055705747 0.291607354 17 50080317 50080375 59 + 1.222 1.065 -0.564
ENSG00000005884 E044 0.1308682 0.0326491905 1.0000000000   17 50081097 50081193 97 + 0.000 0.067 11.610
ENSG00000005884 E045 16.6150313 0.0022708182 0.5734250718 0.752579415 17 50081310 50081408 99 + 1.206 1.154 -0.184
ENSG00000005884 E046 4.8105418 0.0361494559 0.0004807872 0.005501936 17 50086329 50087743 1415 + 1.042 0.503 -2.195
ENSG00000005884 E047 14.6607074 0.0048911375 0.8998259276 0.951809668 17 50087744 50087869 126 + 1.131 1.121 -0.036
ENSG00000005884 E048 0.0000000       17 50088213 50088224 12 +      
ENSG00000005884 E049 11.2841714 0.0081414547 0.4517855656 0.666952781 17 50088225 50088366 142 + 0.931 1.026 0.354
ENSG00000005884 E050 65.4128001 0.0008791103 0.9353927193 0.969864573 17 50089110 50090189 1080 + 1.740 1.738 -0.007
ENSG00000005884 E051 17.5221663 0.0025911348 0.0187608978 0.091586856 17 50090190 50090481 292 + 0.962 1.220 0.937