ENSG00000005801

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000005082 ENSG00000005801 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF195 protein_coding protein_coding 12.68971 5.730856 18.93708 0.7158401 0.8257446 1.722638 2.85223938 0.9919747 4.4678894 0.5261848 0.3944060 2.1599729 0.21407500 0.16203333 0.2350333 0.07300000 0.83666812 0.01173325 FALSE  
ENST00000354599 ENSG00000005801 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF195 protein_coding protein_coding 12.68971 5.730856 18.93708 0.7158401 0.8257446 1.722638 3.52251967 2.0664059 5.8310276 0.2578617 0.3344340 1.4921337 0.30274167 0.36390000 0.3077000 -0.05620000 0.78182722 0.01173325 FALSE  
ENST00000526601 ENSG00000005801 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF195 protein_coding protein_coding 12.68971 5.730856 18.93708 0.7158401 0.8257446 1.722638 1.56692531 0.6390645 2.5073352 0.1123620 0.2039461 1.9554636 0.11706667 0.11730000 0.1337667 0.01646667 0.92537099 0.01173325 FALSE  
ENST00000528796 ENSG00000005801 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF195 protein_coding protein_coding 12.68971 5.730856 18.93708 0.7158401 0.8257446 1.722638 0.34015845 0.4605732 0.4241431 0.1876243 0.1140185 -0.1162484 0.04119167 0.07530000 0.0226000 -0.05270000 0.13604651 0.01173325 FALSE  
ENST00000620374 ENSG00000005801 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF195 protein_coding protein_coding 12.68971 5.730856 18.93708 0.7158401 0.8257446 1.722638 0.07143389 0.2624020 0.0000000 0.1532467 0.0000000 -4.7676656 0.01142083 0.05126667 0.0000000 -0.05126667 0.01173325 0.01173325 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000005801 E001 8.0622269 0.0067194135 2.628568e-06 6.616145e-05 11 3339261 3339822 562 - 0.688 1.225 2.025
ENSG00000005801 E002 3.1585847 0.0081684000 8.771119e-02 2.594789e-01 11 3355830 3355906 77 - 0.483 0.748 1.169
ENSG00000005801 E003 0.4873834 0.1954453346 2.195100e-01   11 3357927 3357927 1 - 0.080 0.307 2.344
ENSG00000005801 E004 4.5784208 0.0228630560 1.213359e-03 1.153343e-02 11 3357928 3358102 175 - 0.511 0.986 1.952
ENSG00000005801 E005 18.3643810 0.0033312536 7.455127e-03 4.681905e-02 11 3358103 3358410 308 - 1.167 1.389 0.778
ENSG00000005801 E006 14.8702567 0.0036746885 6.900129e-01 8.290768e-01 11 3358411 3358468 58 - 1.148 1.184 0.126
ENSG00000005801 E007 83.5187075 0.0193281943 3.751095e-01 6.082667e-01 11 3358469 3358944 476 - 1.867 1.923 0.188
ENSG00000005801 E008 34.5832345 0.0051190153 3.664159e-01 6.010282e-01 11 3358945 3358993 49 - 1.494 1.553 0.203
ENSG00000005801 E009 46.4735334 0.0015408964 4.414372e-01 6.596988e-01 11 3358994 3359116 123 - 1.625 1.666 0.139
ENSG00000005801 E010 277.5154878 0.0036680122 7.091227e-01 8.411924e-01 11 3359117 3359996 880 - 2.409 2.393 -0.055
ENSG00000005801 E011 52.5652112 0.0125543979 7.941739e-01 8.928410e-01 11 3359997 3360038 42 - 1.699 1.680 -0.065
ENSG00000005801 E012 98.1779330 0.0005892405 6.948792e-01 8.322212e-01 11 3360039 3360282 244 - 1.962 1.945 -0.058
ENSG00000005801 E013 36.1130441 0.0061962892 4.425655e-01 6.604362e-01 11 3360283 3360315 33 - 1.544 1.484 -0.206
ENSG00000005801 E014 23.4617262 0.0497034681 8.487592e-01 9.242236e-01 11 3360316 3360319 4 - 1.346 1.342 -0.017
ENSG00000005801 E015 25.0911618 0.0486788193 9.359738e-01 9.702042e-01 11 3360320 3360343 24 - 1.378 1.362 -0.054
ENSG00000005801 E016 16.6265218 0.0248177272 9.653077e-01 9.845496e-01 11 3360344 3360349 6 - 1.204 1.199 -0.018
ENSG00000005801 E017 23.6967250 0.0093327242 8.183359e-01 9.070912e-01 11 3360350 3360384 35 - 1.344 1.361 0.057
ENSG00000005801 E018 19.6118223 0.0232661210 8.013112e-01 8.970821e-01 11 3360385 3360410 26 - 1.267 1.286 0.069
ENSG00000005801 E019 18.5289462 0.0068618178 6.330831e-01 7.923593e-01 11 3360411 3360415 5 - 1.235 1.275 0.141
ENSG00000005801 E020 21.3134178 0.0071292722 7.656307e-01 8.760608e-01 11 3360416 3360424 9 - 1.298 1.320 0.078
ENSG00000005801 E021 30.9388271 0.0023263985 7.073281e-01 8.401157e-01 11 3360425 3360452 28 - 1.469 1.440 -0.100
ENSG00000005801 E022 33.0611875 0.0011997631 8.980588e-03 5.374081e-02 11 3360453 3360477 25 - 1.538 1.351 -0.645
ENSG00000005801 E023 54.3335653 0.0007488954 4.804761e-01 6.874069e-01 11 3360478 3360565 88 - 1.715 1.676 -0.133
ENSG00000005801 E024 4.2566415 0.0111025091 2.564010e-02 1.141926e-01 11 3360720 3360788 69 - 0.562 0.884 1.327
ENSG00000005801 E025 20.5919830 0.0017276113 3.904865e-01 6.208324e-01 11 3361743 3361782 40 - 1.273 1.341 0.235
ENSG00000005801 E026 17.1361251 0.0021637153 9.129114e-01 9.585723e-01 11 3361783 3361808 26 - 1.218 1.225 0.027
ENSG00000005801 E027 20.9706827 0.0021364553 9.947833e-01 9.989569e-01 11 3361809 3361889 81 - 1.301 1.298 -0.008
ENSG00000005801 E028 5.6330572 0.0061875894 7.268367e-01 8.523232e-01 11 3361890 3361975 86 - 0.800 0.748 -0.207
ENSG00000005801 E029 4.3065042 0.0058109297 7.704626e-01 8.789442e-01 11 3361976 3362017 42 - 0.706 0.660 -0.194
ENSG00000005801 E030 4.2579835 0.0067638687 4.710328e-01 6.808601e-01 11 3362018 3362032 15 - 0.723 0.608 -0.486
ENSG00000005801 E031 4.7448193 0.0074378108 5.346702e-01 7.254261e-01 11 3362033 3362073 41 - 0.755 0.659 -0.397
ENSG00000005801 E032 5.1823106 0.0056791750 8.208431e-01 9.085187e-01 11 3362074 3362532 459 - 0.755 0.785 0.119
ENSG00000005801 E033 0.8346052 0.1632234513 7.205158e-01   11 3362533 3362545 13 - 0.261 0.180 -0.684
ENSG00000005801 E034 2.4197581 0.0464511963 5.002460e-01 7.009288e-01 11 3362546 3362567 22 - 0.538 0.403 -0.678
ENSG00000005801 E035 3.1281794 0.0418823686 7.558297e-01 8.700949e-01 11 3362568 3362602 35 - 0.608 0.549 -0.267
ENSG00000005801 E036 11.4908492 0.0029315355 5.289525e-02 1.864744e-01 11 3362603 3363317 715 - 0.990 1.184 0.703
ENSG00000005801 E037 4.5963149 0.0134763322 2.995737e-01 5.400003e-01 11 3363318 3363391 74 - 0.669 0.820 0.611
ENSG00000005801 E038 34.7143938 0.0208506769 8.268249e-01 9.119325e-01 11 3363392 3366690 3299 - 1.515 1.501 -0.046
ENSG00000005801 E039 5.2367795 0.1372561456 3.978942e-01 6.266842e-01 11 3366691 3366843 153 - 0.711 0.853 0.568
ENSG00000005801 E040 5.0741464 0.0987483606 9.674656e-01 9.856680e-01 11 3366844 3366945 102 - 0.743 0.750 0.029
ENSG00000005801 E041 3.1184493 0.0702332793 4.943176e-01 6.969420e-01 11 3366946 3367057 112 - 0.610 0.485 -0.582
ENSG00000005801 E042 17.3203455 0.0712339519 6.452492e-01 8.003645e-01 11 3367058 3368791 1734 - 1.235 1.180 -0.194
ENSG00000005801 E043 2.2412927 0.1162956715 6.796992e-01 8.225032e-01 11 3368792 3368820 29 - 0.508 0.407 -0.518
ENSG00000005801 E044 1.3919723 0.0141504185 2.919028e-02 1.249388e-01 11 3368821 3368855 35 - 0.452 0.000 -13.014
ENSG00000005801 E045 2.1056024 0.1238363081 7.046349e-01 8.385034e-01 11 3369241 3369356 116 - 0.425 0.489 0.331
ENSG00000005801 E046 6.3816311 0.0054102764 1.366920e-01 3.424419e-01 11 3369357 3369502 146 - 0.877 0.660 -0.873
ENSG00000005801 E047 2.7095918 0.1203507853 2.009250e-01 4.308693e-01 11 3370943 3370974 32 - 0.604 0.309 -1.542
ENSG00000005801 E048 28.4956796 0.0034693491 7.699343e-01 8.785835e-01 11 3370975 3370979 5 - 1.440 1.414 -0.087
ENSG00000005801 E049 56.7878642 0.0168846359 9.113970e-01 9.579089e-01 11 3370980 3371070 91 - 1.722 1.730 0.027
ENSG00000005801 E050 0.1614157 0.0338968247 1.000000e+00   11 3371071 3371147 77 - 0.081 0.000 -9.912
ENSG00000005801 E051 74.3174581 0.0198696789 1.460098e-01 3.563865e-01 11 3371577 3371703 127 - 1.869 1.751 -0.396
ENSG00000005801 E052 13.6438143 0.0130642842 6.881595e-01 8.279512e-01 11 3373577 3373656 80 - 1.137 1.086 -0.183
ENSG00000005801 E053 0.3447487 0.3211748223 8.644704e-02   11 3373657 3373675 19 - 0.000 0.308 11.051
ENSG00000005801 E054 0.4576437 0.1854468416 8.349210e-01   11 3375497 3375662 166 - 0.147 0.180 0.345
ENSG00000005801 E055 4.9023457 0.1709035127 7.190435e-01 8.475868e-01 11 3377617 3377802 186 - 0.717 0.808 0.364
ENSG00000005801 E056 1.9201969 0.2345838736 4.481654e-01 6.643691e-01 11 3377803 3377900 98 - 0.504 0.299 -1.142
ENSG00000005801 E057 54.3812927 0.0115490123 2.173486e-01 4.502494e-01 11 3379038 3379222 185 - 1.730 1.641 -0.303