ENSG00000005700

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306270 ENSG00000005700 HEK293_OSMI2_6hA HEK293_TMG_6hB IBTK protein_coding protein_coding 7.246914 2.445017 12.99611 0.6198395 0.4457869 2.405385 4.8248229 1.71927679 8.7335272 0.59929889 0.48428624 2.3380466 0.59367917 0.666600000 0.67610000 0.00950000 1.000000000 0.008452158 FALSE TRUE
ENST00000445419 ENSG00000005700 HEK293_OSMI2_6hA HEK293_TMG_6hB IBTK protein_coding retained_intron 7.246914 2.445017 12.99611 0.6198395 0.4457869 2.405385 0.5787935 0.30227267 0.7109179 0.11831930 0.22480160 1.2070287 0.15022500 0.131766667 0.05366667 -0.07810000 0.491408233 0.008452158 TRUE TRUE
ENST00000508381 ENSG00000005700 HEK293_OSMI2_6hA HEK293_TMG_6hB IBTK protein_coding retained_intron 7.246914 2.445017 12.99611 0.6198395 0.4457869 2.405385 0.1899341 0.06103308 0.1405188 0.06103308 0.04123635 1.0833804 0.06187500 0.044200000 0.01063333 -0.03356667 1.000000000 0.008452158 FALSE FALSE
ENST00000610980 ENSG00000005700 HEK293_OSMI2_6hA HEK293_TMG_6hB IBTK protein_coding protein_coding 7.246914 2.445017 12.99611 0.6198395 0.4457869 2.405385 0.4044139 0.24720583 0.4159479 0.24720583 0.21995547 0.7277536 0.07532500 0.101866667 0.03093333 -0.07093333 0.949307464 0.008452158 FALSE TRUE
MSTRG.28584.7 ENSG00000005700 HEK293_OSMI2_6hA HEK293_TMG_6hB IBTK protein_coding   7.246914 2.445017 12.99611 0.6198395 0.4457869 2.405385 0.6478979 0.01574570 1.7107636 0.01574570 0.49126414 6.0625734 0.05272083 0.004466667 0.12963333 0.12516667 0.008452158 0.008452158 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000005700 E001 0.0000000       6 82169986 82169986 1 -      
ENSG00000005700 E002 1.9474498 0.1518836187 1.104335e-01 0.2996984350 6 82169987 82170235 249 - 0.299 0.671 1.894
ENSG00000005700 E003 0.8928518 0.3170966056 1.226112e-02   6 82170236 82170238 3 - 0.058 0.604 4.401
ENSG00000005700 E004 90.0906914 1.2833577813 2.306509e-01 0.4658858959 6 82170239 82170742 504 - 1.693 2.214 1.752
ENSG00000005700 E005 101.6305992 1.3653531979 3.268488e-01 0.5660099258 6 82170743 82171402 660 - 1.785 2.197 1.383
ENSG00000005700 E006 24.0476023 0.6712592237 2.390469e-01 0.4755148876 6 82171403 82171411 9 - 1.203 1.540 1.170
ENSG00000005700 E007 37.7661676 0.8153114555 2.995947e-01 0.5400266573 6 82171412 82171507 96 - 1.401 1.701 1.029
ENSG00000005700 E008 33.7679578 0.8034087961 3.173734e-01 0.5573429790 6 82171508 82171556 49 - 1.360 1.637 0.951
ENSG00000005700 E009 60.2710796 0.0357658604 5.225677e-02 0.1849729189 6 82172380 82172512 133 - 1.617 1.860 0.823
ENSG00000005700 E010 1.7577149 0.2155474316 9.511468e-01 0.9775464788 6 82172513 82173366 854 - 0.360 0.390 0.172
ENSG00000005700 E011 49.2587320 0.0138240346 7.177437e-03 0.0454709335 6 82173367 82173438 72 - 1.524 1.797 0.927
ENSG00000005700 E012 1.0879220 0.0161631900 1.843348e-01   6 82173439 82173578 140 - 0.303 0.000 -10.717
ENSG00000005700 E013 1.4772473 0.3238939413 3.934532e-01 0.6231171322 6 82174898 82175002 105 - 0.275 0.499 1.285
ENSG00000005700 E014 68.0185492 0.0006535135 1.797149e-01 0.4035977716 6 82181879 82182028 150 - 1.692 1.846 0.519
ENSG00000005700 E015 61.5004731 0.0076064178 8.055221e-01 0.8993837727 6 82191073 82191216 144 - 1.666 1.736 0.239
ENSG00000005700 E016 1.7855020 0.0116364350 6.155421e-02 0.2062897370 6 82191217 82191330 114 - 0.413 0.000 -11.371
ENSG00000005700 E017 4.0568649 0.0067054609 1.866043e-02 0.0912643051 6 82191331 82191786 456 - 0.663 0.236 -2.324
ENSG00000005700 E018 60.4075487 0.0101049228 4.243176e-01 0.6468191826 6 82191787 82191879 93 - 1.666 1.694 0.093
ENSG00000005700 E019 58.3944580 0.0069856191 5.843220e-01 0.7598851775 6 82194479 82194595 117 - 1.647 1.691 0.148
ENSG00000005700 E020 45.3628730 0.0039055575 1.982740e-01 0.4274387755 6 82194596 82194642 47 - 1.547 1.542 -0.018
ENSG00000005700 E021 57.6634191 0.0008660152 7.522363e-01 0.8680774586 6 82196298 82196401 104 - 1.631 1.735 0.352
ENSG00000005700 E022 34.1573944 0.0014159661 4.162748e-01 0.6408298400 6 82196402 82196446 45 - 1.400 1.542 0.490
ENSG00000005700 E023 63.9928692 0.0125102660 8.044711e-01 0.8989048980 6 82200141 82200253 113 - 1.679 1.749 0.235
ENSG00000005700 E024 55.7504186 0.0117487754 7.758385e-01 0.8822796128 6 82200587 82200708 122 - 1.622 1.689 0.228
ENSG00000005700 E025 44.6168777 0.0153199976 3.891989e-01 0.6198731554 6 82201422 82201482 61 - 1.537 1.548 0.037
ENSG00000005700 E026 55.1914672 0.0023320955 7.951293e-02 0.2438751705 6 82202528 82202645 118 - 1.632 1.601 -0.105
ENSG00000005700 E027 45.6398869 0.0141069940 5.414767e-02 0.1894343036 6 82204857 82204958 102 - 1.560 1.465 -0.326
ENSG00000005700 E028 7.4212082 0.0745266228 2.405540e-01 0.4772049858 6 82204959 82205929 971 - 0.848 0.661 -0.758
ENSG00000005700 E029 39.7413829 0.0056387358 1.869597e-01 0.4129928064 6 82210814 82210910 97 - 1.493 1.474 -0.064
ENSG00000005700 E030 24.3092285 0.0036151622 1.856981e-01 0.4114689542 6 82211367 82211404 38 - 1.299 1.261 -0.134
ENSG00000005700 E031 32.6012113 0.0015262256 8.802792e-02 0.2600804836 6 82211490 82211572 83 - 1.420 1.368 -0.180
ENSG00000005700 E032 41.0955344 0.0100489975 3.350628e-01 0.5736199303 6 82212707 82212793 87 - 1.505 1.519 0.049
ENSG00000005700 E033 133.4474004 0.0083006039 9.859895e-02 0.2793428678 6 82214227 82214829 603 - 2.010 1.998 -0.041
ENSG00000005700 E034 56.0381449 0.0085914341 3.339131e-02 0.1371601780 6 82216076 82216250 175 - 1.647 1.568 -0.272
ENSG00000005700 E035 50.0445965 0.0266669491 4.972157e-01 0.6990602416 6 82217960 82218137 178 - 1.583 1.594 0.036
ENSG00000005700 E036 45.1239861 0.0230430699 2.384134e-01 0.4748165259 6 82220590 82220713 124 - 1.548 1.505 -0.148
ENSG00000005700 E037 54.0326091 0.0007827606 1.343916e-03 0.0124911104 6 82223440 82223620 181 - 1.639 1.515 -0.426
ENSG00000005700 E038 49.1862535 0.0008058354 2.335448e-05 0.0004358862 6 82224068 82224185 118 - 1.613 1.394 -0.750
ENSG00000005700 E039 52.4409753 0.0007888308 1.495280e-02 0.0779102712 6 82225477 82225647 171 - 1.622 1.551 -0.241
ENSG00000005700 E040 0.0000000       6 82227164 82227191 28 -      
ENSG00000005700 E041 37.9702427 0.0011518516 2.323844e-02 0.1067119429 6 82227192 82227302 111 - 1.492 1.406 -0.295
ENSG00000005700 E042 46.6860479 0.0208298496 2.919984e-03 0.0229192290 6 82231718 82231842 125 - 1.589 1.386 -0.697
ENSG00000005700 E043 37.4108870 0.0053162298 2.395542e-04 0.0031050076 6 82234159 82234255 97 - 1.500 1.261 -0.830
ENSG00000005700 E044 89.4750017 0.0191580768 1.003222e-02 0.0582940251 6 82240166 82240843 678 - 1.855 1.735 -0.407
ENSG00000005700 E045 26.8887220 0.0013298775 6.809004e-03 0.0437322894 6 82247562 82247754 193 - 1.355 1.188 -0.588