ENSG00000005483

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257745 ENSG00000005483 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT2E protein_coding nonsense_mediated_decay 7.507142 4.163765 14.47109 0.5648992 0.8322299 1.794749 0.6285696 0.90318487 1.3059852 0.19321633 0.3071562 0.5271644 0.13200417 0.23100000 0.09340000 -0.137600000 3.884679e-01 3.322105e-10 FALSE TRUE
ENST00000311117 ENSG00000005483 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT2E protein_coding protein_coding 7.507142 4.163765 14.47109 0.5648992 0.8322299 1.794749 3.4397452 2.42959732 6.2543872 0.65646446 0.1784372 1.3605303 0.50889583 0.56286667 0.43370000 -0.129166667 7.255740e-01 3.322105e-10 FALSE TRUE
ENST00000476671 ENSG00000005483 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT2E protein_coding protein_coding 7.507142 4.163765 14.47109 0.5648992 0.8322299 1.794749 0.3980073 0.24657341 0.8866766 0.07082598 0.1230970 1.8052161 0.05558333 0.06710000 0.06256667 -0.004533333 1.000000e+00 3.322105e-10 FALSE TRUE
ENST00000478079 ENSG00000005483 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT2E protein_coding nonsense_mediated_decay 7.507142 4.163765 14.47109 0.5648992 0.8322299 1.794749 0.6018759 0.29000176 1.1117424 0.29000176 0.7354508 1.9026986 0.06648333 0.05813333 0.07443333 0.016300000 8.271418e-01 3.322105e-10 FALSE FALSE
ENST00000478990 ENSG00000005483 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT2E protein_coding protein_coding 7.507142 4.163765 14.47109 0.5648992 0.8322299 1.794749 0.6446242 0.02563306 1.1148958 0.02563306 0.7158082 4.9804311 0.05062917 0.00580000 0.07433333 0.068533333 7.048118e-01 3.322105e-10 FALSE TRUE
ENST00000495267 ENSG00000005483 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT2E protein_coding protein_coding 7.507142 4.163765 14.47109 0.5648992 0.8322299 1.794749 1.1519870 0.00000000 2.3641455 0.00000000 0.2699076 7.8912645 0.09960000 0.00000000 0.16423333 0.164233333 3.322105e-10 3.322105e-10 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000005483 E001 0.0000000       7 104940943 104940943 1 +      
ENSG00000005483 E002 0.0000000       7 104940944 104941062 119 +      
ENSG00000005483 E003 0.0000000       7 104941063 104941551 489 +      
ENSG00000005483 E004 0.0000000       7 104941552 104941661 110 +      
ENSG00000005483 E005 0.0000000       7 104941662 104941670 9 +      
ENSG00000005483 E006 0.0000000       7 104941671 104941745 75 +      
ENSG00000005483 E007 0.0000000       7 104961984 104962199 216 +      
ENSG00000005483 E008 0.0000000       7 104962200 104962284 85 +      
ENSG00000005483 E009 0.0000000       7 104962285 104962357 73 +      
ENSG00000005483 E010 0.0000000       7 104962358 104963216 859 +      
ENSG00000005483 E011 0.0000000       7 105000193 105000255 63 +      
ENSG00000005483 E012 0.5339515 0.9902419705 0.6296751220   7 105000256 105000713 458 + 0.221 0.000 -12.316
ENSG00000005483 E013 1.4925100 0.6917940695 0.2746298479 0.514602942 7 105013317 105014163 847 + 0.205 0.618 2.390
ENSG00000005483 E014 0.1308682 0.0309062489 0.2469967615   7 105014164 105014189 26 + 0.000 0.175 13.035
ENSG00000005483 E015 2.2471235 0.1611743704 0.7760633163 0.882387524 7 105014190 105014204 15 + 0.458 0.546 0.426
ENSG00000005483 E016 2.2471235 0.1611743704 0.7760633163 0.882387524 7 105014205 105014205 1 + 0.458 0.546 0.426
ENSG00000005483 E017 2.2471235 0.1611743704 0.7760633163 0.882387524 7 105014206 105014206 1 + 0.458 0.546 0.426
ENSG00000005483 E018 2.2471235 0.1611743704 0.7760633163 0.882387524 7 105014207 105014207 1 + 0.458 0.546 0.426
ENSG00000005483 E019 3.6284970 0.1975751052 0.8159802533 0.905830999 7 105014208 105014217 10 + 0.650 0.608 -0.185
ENSG00000005483 E020 32.1173733 0.0823404508 0.7145017451 0.844625016 7 105014218 105014431 214 + 1.463 1.537 0.254
ENSG00000005483 E021 22.8067888 0.0149887643 0.7917707208 0.891478560 7 105014432 105014460 29 + 1.316 1.405 0.309
ENSG00000005483 E022 32.2492568 0.0019599306 0.7795049763 0.884456691 7 105014461 105014535 75 + 1.469 1.523 0.185
ENSG00000005483 E023 7.2782437 0.0121875324 0.2173721307 0.450268191 7 105038126 105038199 74 + 0.910 0.811 -0.383
ENSG00000005483 E024 0.9396778 0.0172671820 0.3673037400   7 105038385 105038525 141 + 0.311 0.175 -1.073
ENSG00000005483 E025 0.0000000       7 105039153 105039269 117 +      
ENSG00000005483 E026 16.2074837 0.0127124819 0.0842029204 0.253181402 7 105040839 105040847 9 + 1.223 1.114 -0.389
ENSG00000005483 E027 17.8362543 0.0085718712 0.0427303514 0.161858379 7 105040848 105040857 10 + 1.269 1.145 -0.442
ENSG00000005483 E028 46.7985102 0.0211518792 0.1874050878 0.413600019 7 105040858 105041023 166 + 1.656 1.617 -0.130
ENSG00000005483 E029 0.0000000       7 105061918 105062163 246 +      
ENSG00000005483 E030 28.3195370 0.0032234242 0.1187307165 0.313780271 7 105062164 105062197 34 + 1.444 1.404 -0.140
ENSG00000005483 E031 41.9200186 0.0066306989 0.0065911758 0.042655290 7 105062198 105062278 81 + 1.629 1.515 -0.389
ENSG00000005483 E032 70.3489694 0.0325640142 0.0024680324 0.020125260 7 105063351 105063580 230 + 1.873 1.653 -0.744
ENSG00000005483 E033 2.4006172 0.0186576926 0.0151163028 0.078542892 7 105063581 105063827 247 + 0.595 0.175 -2.565
ENSG00000005483 E034 1.2659058 0.0168668508 0.0221667348   7 105064028 105064116 89 + 0.427 0.000 -13.580
ENSG00000005483 E035 38.5740307 0.0114881502 0.0339631750 0.138757386 7 105066727 105066807 81 + 1.591 1.500 -0.313
ENSG00000005483 E036 0.3559677 0.6629632344 0.6413358462   7 105068475 105068545 71 + 0.157 0.000 -11.632
ENSG00000005483 E037 42.4036660 0.0019149061 0.0005883348 0.006476209 7 105073619 105073677 59 + 1.641 1.502 -0.473
ENSG00000005483 E038 67.3807291 0.0006901536 0.0001105646 0.001625505 7 105074643 105074815 173 + 1.834 1.725 -0.366
ENSG00000005483 E039 42.2123230 0.0012391288 0.0005183680 0.005842623 7 105076043 105076081 39 + 1.639 1.502 -0.465
ENSG00000005483 E040 68.6312806 0.0027123359 0.0003868740 0.004603749 7 105076963 105077115 153 + 1.838 1.729 -0.366
ENSG00000005483 E041 44.2434989 0.0159765407 0.0071738697 0.045456814 7 105077116 105077193 78 + 1.659 1.518 -0.481
ENSG00000005483 E042 51.2957609 0.0106788069 0.0118838520 0.065948349 7 105077303 105077433 131 + 1.711 1.609 -0.346
ENSG00000005483 E043 0.1426347 0.0314845668 1.0000000000   7 105077434 105077808 375 + 0.082 0.000 -10.579
ENSG00000005483 E044 45.3146034 0.0260117909 0.0151611318 0.078689147 7 105078846 105078963 118 + 1.671 1.522 -0.509
ENSG00000005483 E045 44.4107530 0.0205221450 0.0340781632 0.139075403 7 105081688 105081797 110 + 1.652 1.540 -0.383
ENSG00000005483 E046 0.6434498 0.0195608492 0.1486354103   7 105089226 105089361 136 + 0.264 0.000 -12.581
ENSG00000005483 E047 72.1910077 0.0243305024 0.3972764714 0.626150553 7 105090009 105090273 265 + 1.826 1.829 0.010
ENSG00000005483 E048 47.5188698 0.0167765380 0.2927177261 0.533439954 7 105091216 105091314 99 + 1.650 1.641 -0.028
ENSG00000005483 E049 5.5453222 0.0053861837 0.1093853963 0.298096093 7 105091315 105091609 295 + 0.679 0.952 1.078
ENSG00000005483 E050 31.1466696 0.0037762882 0.1697105086 0.390112722 7 105101425 105101470 46 + 1.476 1.453 -0.080
ENSG00000005483 E051 45.5742035 0.0094586822 0.0763354943 0.237422806 7 105101471 105101589 119 + 1.643 1.591 -0.179
ENSG00000005483 E052 72.5588773 0.0005957073 0.2232330791 0.457233105 7 105101886 105102194 309 + 1.824 1.846 0.072
ENSG00000005483 E053 1.6708740 0.0143248417 0.1655437156 0.384621379 7 105102195 105102649 455 + 0.311 0.599 1.505
ENSG00000005483 E054 58.8579085 0.0126206428 0.6340949423 0.793029615 7 105105439 105105693 255 + 1.732 1.772 0.137
ENSG00000005483 E055 45.0641878 0.0012787718 0.0975533557 0.277514842 7 105105859 105105955 97 + 1.638 1.620 -0.063
ENSG00000005483 E056 36.6766321 0.0012647767 0.4490158684 0.665010359 7 105105956 105106003 48 + 1.538 1.565 0.095
ENSG00000005483 E057 81.3702417 0.0006165034 0.8823555730 0.942514991 7 105106522 105106772 251 + 1.857 1.927 0.234
ENSG00000005483 E058 45.4380770 0.0008526126 0.2292208501 0.464217667 7 105107166 105107222 57 + 1.628 1.636 0.027
ENSG00000005483 E059 140.7994767 0.0061285620 0.5075841631 0.706078417 7 105107362 105107899 538 + 2.098 2.148 0.167
ENSG00000005483 E060 31.6088973 0.0065647569 0.6021104389 0.771557502 7 105107900 105107925 26 + 1.440 1.549 0.376
ENSG00000005483 E061 2.4474185 0.9245022654 0.5907923312 0.764250275 7 105108544 105108658 115 + 0.570 0.306 -1.407
ENSG00000005483 E062 50.5358324 0.0070268809 0.5888914364 0.762907919 7 105108942 105109039 98 + 1.636 1.748 0.380
ENSG00000005483 E063 77.1321848 0.0024858155 0.1197912224 0.315536746 7 105109040 105109228 189 + 1.804 1.954 0.506
ENSG00000005483 E064 59.1137960 0.0007442447 0.0077953708 0.048362739 7 105110280 105110368 89 + 1.675 1.875 0.677
ENSG00000005483 E065 55.2839129 0.0519831663 0.0295910186 0.126144929 7 105110477 105110602 126 + 1.601 1.901 1.012
ENSG00000005483 E066 48.8158864 0.7833963835 0.3345004560 0.573078880 7 105110771 105110868 98 + 1.556 1.836 0.948
ENSG00000005483 E067 331.0732101 0.4106027386 0.0821410744 0.248994943 7 105111825 105115345 3521 + 2.307 2.734 1.423