ENSG00000005339

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262367 ENSG00000005339 HEK293_OSMI2_6hA HEK293_TMG_6hB CREBBP protein_coding protein_coding 20.28563 28.69281 20.77247 2.052017 0.7972729 -0.4658251 9.5231469 16.2797722 4.9390719 2.5612627 2.4741502 -1.7187365 0.47855833 0.56010000 0.23676667 -0.32333333 0.69992417 8.513723e-05 FALSE TRUE
ENST00000570939 ENSG00000005339 HEK293_OSMI2_6hA HEK293_TMG_6hB CREBBP protein_coding protein_coding 20.28563 28.69281 20.77247 2.052017 0.7972729 -0.4658251 1.1719739 1.7121105 1.9233991 0.2278033 0.9662358 0.1669618 0.05545000 0.06136667 0.09026667 0.02890000 1.00000000 8.513723e-05 FALSE TRUE
ENST00000571763 ENSG00000005339 HEK293_OSMI2_6hA HEK293_TMG_6hB CREBBP protein_coding retained_intron 20.28563 28.69281 20.77247 2.052017 0.7972729 -0.4658251 1.3020219 2.5991855 0.7647617 0.8320061 0.4055613 -1.7517751 0.06402500 0.09470000 0.03550000 -0.05920000 0.73323681 8.513723e-05   FALSE
ENST00000573517 ENSG00000005339 HEK293_OSMI2_6hA HEK293_TMG_6hB CREBBP protein_coding protein_coding 20.28563 28.69281 20.77247 2.052017 0.7972729 -0.4658251 0.7243737 1.8435639 0.2307877 0.5254209 0.2307877 -2.9444681 0.03431667 0.06376667 0.01123333 -0.05253333 0.22434567 8.513723e-05 FALSE TRUE
MSTRG.11955.10 ENSG00000005339 HEK293_OSMI2_6hA HEK293_TMG_6hB CREBBP protein_coding   20.28563 28.69281 20.77247 2.052017 0.7972729 -0.4658251 2.9242055 0.3146082 8.3699777 0.3146082 1.3575445 4.6901750 0.14245417 0.01266667 0.40410000 0.39143333 0.01329943 8.513723e-05 FALSE TRUE
MSTRG.11955.3 ENSG00000005339 HEK293_OSMI2_6hA HEK293_TMG_6hB CREBBP protein_coding   20.28563 28.69281 20.77247 2.052017 0.7972729 -0.4658251 1.3289106 1.2643056 1.6686280 0.7512279 0.8415583 0.3975713 0.06440417 0.04743333 0.08353333 0.03610000 0.95768390 8.513723e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000005339 E001 605.6489591 1.5104772064 3.338123e-01 5.724023e-01 16 3725054 3727141 2088 - 2.449 2.903 1.512
ENSG00000005339 E002 284.2253955 1.2282738352 2.785253e-01 5.186120e-01 16 3727142 3727538 397 - 2.098 2.581 1.614
ENSG00000005339 E003 552.1401595 1.4988423480 3.605402e-01 5.960904e-01 16 3727539 3728339 801 - 2.439 2.856 1.388
ENSG00000005339 E004 505.2147576 1.4723973705 3.619880e-01 5.973383e-01 16 3728340 3729392 1053 - 2.406 2.816 1.365
ENSG00000005339 E005 179.9631840 1.1139549988 3.273737e-01 5.664695e-01 16 3729393 3729647 255 - 1.980 2.364 1.286
ENSG00000005339 E006 208.6704260 1.1867547275 3.595314e-01 5.954540e-01 16 3729648 3729874 227 - 2.061 2.423 1.209
ENSG00000005339 E007 0.0000000       16 3730512 3730552 41 -      
ENSG00000005339 E008 257.1823540 0.0130244615 4.507072e-02 1.677893e-01 16 3731192 3731473 282 - 2.268 2.476 0.693
ENSG00000005339 E009 194.6621142 0.0013792993 1.394039e-01 3.466076e-01 16 3731776 3731907 132 - 2.192 2.341 0.495
ENSG00000005339 E010 88.3964494 0.0007077170 1.623417e-01 3.802617e-01 16 3731908 3731910 3 - 1.843 2.001 0.531
ENSG00000005339 E011 116.2036763 0.0034264465 3.055918e-01 5.462264e-01 16 3731911 3731937 27 - 1.969 2.114 0.488
ENSG00000005339 E012 150.3477863 0.0028382804 9.003345e-01 9.520334e-01 16 3736036 3736082 47 - 2.107 2.214 0.357
ENSG00000005339 E013 229.4537214 0.0045453249 8.703588e-01 9.361306e-01 16 3736083 3736203 121 - 2.295 2.391 0.319
ENSG00000005339 E014 0.6368449 0.0188915767 1.334473e-01   16 3736508 3736649 142 - 0.000 0.314 12.981
ENSG00000005339 E015 257.0221864 0.0015689393 2.656618e-01 5.050598e-01 16 3736650 3736815 166 - 2.361 2.429 0.224
ENSG00000005339 E016 4.5786969 0.2341694757 7.441584e-01 8.631008e-01 16 3736816 3736999 184 - 0.625 0.782 0.652
ENSG00000005339 E017 184.0320485 0.0002823179 6.713415e-02 2.187111e-01 16 3738559 3738672 114 - 2.230 2.281 0.170
ENSG00000005339 E018 2.5928453 0.0990826972 5.199099e-01 7.149493e-01 16 3739446 3739577 132 - 0.411 0.621 1.014
ENSG00000005339 E019 204.3618424 0.0017529306 7.040466e-02 2.255159e-01 16 3739578 3739724 147 - 2.279 2.321 0.141
ENSG00000005339 E020 153.1554773 0.0071284049 9.436937e-01 9.741948e-01 16 3740399 3740442 44 - 2.118 2.215 0.326
ENSG00000005339 E021 215.2368756 0.0024872715 6.298723e-01 7.903697e-01 16 3740443 3740549 107 - 2.274 2.358 0.283
ENSG00000005339 E022 7.4445062 0.2825009738 9.015945e-01 9.526882e-01 16 3740550 3743468 2919 - 0.844 0.955 0.424
ENSG00000005339 E023 0.6536007 0.0401148331 6.879922e-01   16 3743663 3743732 70 - 0.144 0.254 1.019
ENSG00000005339 E024 177.1667047 0.0011933264 3.369217e-02 1.380520e-01 16 3744894 3744961 68 - 2.222 2.256 0.114
ENSG00000005339 E025 167.6971912 0.0049348071 3.363361e-02 1.378632e-01 16 3745277 3745354 78 - 2.213 2.221 0.028
ENSG00000005339 E026 3.4026848 0.0080829698 2.826872e-01 5.231117e-01 16 3745355 3745555 201 - 0.471 0.720 1.115
ENSG00000005339 E027 1.8808628 0.0181849844 9.363525e-01 9.704035e-01 16 3745556 3745595 40 - 0.410 0.457 0.251
ENSG00000005339 E028 1.4184174 0.1753481471 9.543001e-01 9.790402e-01 16 3745596 3745654 59 - 0.337 0.377 0.235
ENSG00000005339 E029 140.7826326 0.0116613124 5.012554e-02 1.799776e-01 16 3749627 3749683 57 - 2.152 2.135 -0.057
ENSG00000005339 E030 128.1410783 0.0078283802 2.632039e-01 5.023950e-01 16 3751726 3751806 81 - 2.076 2.117 0.138
ENSG00000005339 E031 4.9411291 0.1569354020 7.233366e-01 8.501084e-01 16 3751807 3751836 30 - 0.663 0.809 0.598
ENSG00000005339 E032 113.9377015 0.0012402927 6.287147e-01 7.896725e-01 16 3757288 3757376 89 - 2.001 2.082 0.273
ENSG00000005339 E033 243.8281483 0.0121594609 1.490262e-01 3.608600e-01 16 3757809 3758048 240 - 2.369 2.387 0.060
ENSG00000005339 E034 175.7639784 0.0070319714 2.947786e-01 5.353074e-01 16 3758854 3758972 119 - 2.208 2.258 0.169
ENSG00000005339 E035 0.8787002 0.9983349424 6.279439e-01   16 3767302 3767719 418 - 0.351 0.189 -1.188
ENSG00000005339 E036 232.4350779 0.0064247155 9.026028e-02 2.642441e-01 16 3767720 3767909 190 - 2.343 2.370 0.088
ENSG00000005339 E037 229.3518034 0.0081699203 1.040746e-02 5.989754e-02 16 3769174 3769353 180 - 2.368 2.343 -0.082
ENSG00000005339 E038 274.7178400 0.0078680479 8.242116e-03 5.043785e-02 16 3770570 3770932 363 - 2.445 2.423 -0.073
ENSG00000005339 E039 86.8673570 0.0137724581 2.002623e-02 9.596885e-02 16 3770933 3770980 48 - 1.967 1.916 -0.172
ENSG00000005339 E040 55.0070541 0.0114956453 3.985871e-03 2.907490e-02 16 3770981 3770986 6 - 1.797 1.702 -0.324
ENSG00000005339 E041 0.0000000       16 3773636 3773705 70 -      
ENSG00000005339 E042 0.5705883 0.3292542537 8.783899e-01   16 3773706 3773750 45 - 0.145 0.245 0.932
ENSG00000005339 E043 173.9568856 0.0111996048 7.995584e-03 4.928576e-02 16 3773751 3773930 180 - 2.263 2.216 -0.159
ENSG00000005339 E044 120.0355676 0.0097219983 2.766736e-02 1.202966e-01 16 3774569 3774652 84 - 2.089 2.066 -0.077
ENSG00000005339 E045 91.6812201 0.0110616279 4.872491e-02 1.766343e-01 16 3774653 3774693 41 - 1.972 1.950 -0.072
ENSG00000005339 E046 0.3088520 0.0282299828 6.439156e-01   16 3774694 3774746 53 - 0.144 0.102 -0.567
ENSG00000005339 E047 80.5491265 0.0185409020 2.286323e-02 1.055197e-01 16 3777613 3777657 45 - 1.945 1.872 -0.247
ENSG00000005339 E048 0.1723744 0.0360246723 8.748109e-01   16 3777947 3778010 64 - 0.000 0.102 10.983
ENSG00000005339 E049 156.0274907 0.0098824685 3.173123e-02 1.324263e-01 16 3778011 3778182 172 - 2.197 2.182 -0.052
ENSG00000005339 E050 145.7949224 0.0049284587 5.724194e-06 1.297171e-04 16 3778700 3778817 118 - 2.217 2.118 -0.331
ENSG00000005339 E051 175.0164300 0.0067306452 5.792935e-05 9.459362e-04 16 3780732 3780878 147 - 2.289 2.200 -0.297
ENSG00000005339 E052 121.9957088 0.0030775150 7.505049e-05 1.176851e-03 16 3781204 3781306 103 - 2.121 2.059 -0.206
ENSG00000005339 E053 142.3775585 0.0048959321 3.977953e-06 9.456158e-05 16 3782684 3782885 202 - 2.211 2.107 -0.349
ENSG00000005339 E054 50.3271134 0.0007717933 5.234718e-06 1.199050e-04 16 3782886 3782889 4 - 1.777 1.646 -0.442
ENSG00000005339 E055 81.6705706 0.0009624410 1.155595e-11 9.836925e-10 16 3782890 3782926 37 - 2.012 1.833 -0.601
ENSG00000005339 E056 0.0000000       16 3784473 3784515 43 -      
ENSG00000005339 E057 0.1308682 0.0326491905 8.760133e-01   16 3791193 3791255 63 - 0.000 0.102 10.978
ENSG00000005339 E058 123.4633618 0.0004246876 2.266495e-17 4.699671e-15 16 3791981 3792094 114 - 2.188 2.012 -0.589
ENSG00000005339 E059 186.1442583 0.0003441251 1.747626e-17 3.685801e-15 16 3793386 3793626 241 - 2.341 2.214 -0.424
ENSG00000005339 E060 124.5547599 0.0004021269 1.200808e-15 1.991453e-13 16 3810603 3810719 117 - 2.183 2.024 -0.531
ENSG00000005339 E061 106.6602093 0.0025580701 2.806148e-09 1.489214e-07 16 3810720 3810779 60 - 2.108 1.961 -0.492
ENSG00000005339 E062 0.3559677 0.6721355398 1.998410e-01   16 3812938 3812977 40 - 0.258 0.000 -13.170
ENSG00000005339 E063 0.3206185 0.0274424043 8.057878e-02   16 3812998 3813072 75 - 0.251 0.000 -13.141
ENSG00000005339 E064 317.5533520 0.0071507934 3.169126e-06 7.787448e-05 16 3850297 3851009 713 - 2.557 2.448 -0.361
ENSG00000005339 E065 0.4646582 0.0217681645 1.000000e+00   16 3854721 3854770 50 - 0.144 0.185 0.435
ENSG00000005339 E066 71.5683133 0.0010736922 4.519372e-02 1.680998e-01 16 3879832 3880713 882 - 1.852 1.865 0.042