ENSG00000005302

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312196 ENSG00000005302 HEK293_OSMI2_6hA HEK293_TMG_6hB MSL3 protein_coding protein_coding 13.91644 9.610397 17.03292 0.3623942 1.135066 0.8250043 7.6584027 5.7679870 8.6372262 0.2381586 0.49173221 0.5816705 0.56496667 0.60096667 0.50986667 -0.09110000 5.470454e-01 7.242011e-07 FALSE TRUE
ENST00000380693 ENSG00000005302 HEK293_OSMI2_6hA HEK293_TMG_6hB MSL3 protein_coding protein_coding 13.91644 9.610397 17.03292 0.3623942 1.135066 0.8250043 0.4487343 0.0000000 1.7656557 0.0000000 0.58116946 7.4722081 0.02817500 0.00000000 0.10023333 0.10023333 7.242011e-07 7.242011e-07 FALSE TRUE
ENST00000398527 ENSG00000005302 HEK293_OSMI2_6hA HEK293_TMG_6hB MSL3 protein_coding protein_coding 13.91644 9.610397 17.03292 0.3623942 1.135066 0.8250043 1.0716939 0.6249236 0.9162552 0.2835821 0.09953628 0.5448267 0.07528333 0.06673333 0.05446667 -0.01226667 9.999435e-01 7.242011e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000005302 E001 0.0000000       X 11758159 11758194 36 +      
ENSG00000005302 E002 0.2027342 0.0362373960 0.3669840774   X 11758195 11758202 8 + 0.000 0.140 10.140
ENSG00000005302 E003 0.4054685 0.6023560975 0.2580468100   X 11758203 11758204 2 + 0.000 0.259 12.810
ENSG00000005302 E004 2.9526261 0.0077358440 0.0445247116 0.166424266 X 11758205 11758225 21 + 0.422 0.746 1.477
ENSG00000005302 E005 5.6955761 0.0306777105 0.1286738470 0.329733650 X 11758226 11758236 11 + 0.707 0.936 0.900
ENSG00000005302 E006 13.1743867 0.0156011100 0.6995274490 0.835327907 X 11758237 11758249 13 + 1.116 1.169 0.191
ENSG00000005302 E007 14.8624938 0.0053346385 0.4733686005 0.682366168 X 11758250 11758252 3 + 1.151 1.231 0.284
ENSG00000005302 E008 19.3191245 0.0044697986 0.8535988496 0.926884365 X 11758253 11758257 5 + 1.281 1.311 0.104
ENSG00000005302 E009 23.7197356 0.0032113529 0.4331532521 0.653565586 X 11758258 11758267 10 + 1.344 1.418 0.255
ENSG00000005302 E010 48.6415687 0.0010422979 0.0595300075 0.201739393 X 11758268 11758365 98 + 1.635 1.747 0.379
ENSG00000005302 E011 0.2617363 0.3367618098 0.2005826755   X 11758556 11758581 26 + 0.000 0.239 12.884
ENSG00000005302 E012 2.2954048 0.4179333004 0.3821333283 0.613960228 X 11758582 11758630 49 + 0.384 0.655 1.306
ENSG00000005302 E013 4.3952101 0.1966081179 0.2661954828 0.505707628 X 11758631 11758688 58 + 0.614 0.842 0.937
ENSG00000005302 E014 6.2712418 0.0779892570 0.9709762804 0.987337206 X 11758689 11758773 85 + 0.850 0.868 0.068
ENSG00000005302 E015 2.5745122 0.0291319869 0.6076535305 0.775317647 X 11758774 11759320 547 + 0.504 0.606 0.468
ENSG00000005302 E016 1.1168538 0.0176567018 0.9963179189   X 11759402 11759423 22 + 0.321 0.331 0.059
ENSG00000005302 E017 1.8982387 0.0257827590 0.8524670040 0.926465061 X 11759424 11759603 180 + 0.422 0.465 0.223
ENSG00000005302 E018 1.3996364 0.0928715343 0.3048994925 0.545475709 X 11759604 11759622 19 + 0.259 0.469 1.253
ENSG00000005302 E019 1.3996364 0.0928715343 0.3048994925 0.545475709 X 11759623 11759625 3 + 0.259 0.469 1.253
ENSG00000005302 E020 1.6023706 0.2021090072 0.2602986986 0.499271916 X 11759626 11759632 7 + 0.258 0.532 1.566
ENSG00000005302 E021 1.8051049 0.2924630978 0.2495461022 0.487402444 X 11759633 11759633 1 + 0.257 0.588 1.829
ENSG00000005302 E022 2.4673358 0.2112789551 0.7318756862 0.855339100 X 11759634 11759640 7 + 0.464 0.584 0.567
ENSG00000005302 E023 2.7879542 0.1335288773 0.9713110054 0.987499619 X 11759641 11759642 2 + 0.539 0.578 0.178
ENSG00000005302 E024 2.6453196 0.1591732280 0.8512432053 0.925717168 X 11759643 11759644 2 + 0.505 0.580 0.352
ENSG00000005302 E025 3.4667533 0.1314177955 0.5871058560 0.761693853 X 11759645 11759647 3 + 0.661 0.578 -0.364
ENSG00000005302 E026 7.0753015 0.0103511786 0.1191122818 0.314402142 X 11759648 11759656 9 + 0.964 0.776 -0.724
ENSG00000005302 E027 7.0753015 0.0103511786 0.1191122818 0.314402142 X 11759657 11759657 1 + 0.964 0.776 -0.724
ENSG00000005302 E028 13.4723625 0.0161701928 0.0640798771 0.211848563 X 11759658 11759686 29 + 1.214 1.026 -0.679
ENSG00000005302 E029 15.4056607 0.0049547278 0.0190681316 0.092710928 X 11759687 11759712 26 + 1.274 1.068 -0.737
ENSG00000005302 E030 18.1269437 0.0057087945 0.0159669083 0.081685442 X 11759713 11759771 59 + 1.344 1.145 -0.703
ENSG00000005302 E031 16.0193160 0.0066115545 0.0112681709 0.063472172 X 11759772 11759792 21 + 1.305 1.081 -0.795
ENSG00000005302 E032 90.3013822 0.0037237255 0.0101248532 0.058673706 X 11759793 11759875 83 + 1.992 1.889 -0.347
ENSG00000005302 E033 0.2027342 0.0362373960 0.3669840774   X 11760043 11760047 5 + 0.000 0.140 12.407
ENSG00000005302 E034 0.2027342 0.0362373960 0.3669840774   X 11760048 11760092 45 + 0.000 0.140 12.407
ENSG00000005302 E035 0.0000000       X 11760093 11760185 93 +      
ENSG00000005302 E036 0.0000000       X 11760186 11760221 36 +      
ENSG00000005302 E037 0.2922838 0.0278610740 0.8295605143   X 11760222 11760309 88 + 0.105 0.140 0.472
ENSG00000005302 E038 0.1614157 0.0325931294 0.6373045958   X 11760310 11760339 30 + 0.105 0.000 -11.758
ENSG00000005302 E039 0.3337900 0.0266819399 0.8307982216   X 11760340 11760402 63 + 0.105 0.140 0.476
ENSG00000005302 E040 93.5264152 0.0051638465 0.0423489369 0.160840531 X 11760403 11760498 96 + 2.002 1.918 -0.283
ENSG00000005302 E041 82.0658280 0.0009620530 0.0001063710 0.001575791 X 11760837 11760909 73 + 1.970 1.825 -0.487
ENSG00000005302 E042 62.0854685 0.0008445171 0.0001139564 0.001665870 X 11760910 11760937 28 + 1.858 1.693 -0.558
ENSG00000005302 E043 4.8933525 0.0057497410 0.0028539555 0.022519621 X 11760938 11761499 562 + 0.894 0.463 -1.846
ENSG00000005302 E044 87.2904989 0.0004429344 0.0132217818 0.071338617 X 11761500 11761582 83 + 1.970 1.889 -0.270
ENSG00000005302 E045 3.5992997 0.3695730826 0.2159892535 0.448602569 X 11761583 11762129 547 + 0.755 0.471 -1.261
ENSG00000005302 E046 104.1242080 0.0004590088 0.0066160553 0.042781036 X 11762130 11762252 123 + 2.047 1.965 -0.273
ENSG00000005302 E047 64.8411866 0.0043340398 0.2781702301 0.518297452 X 11762837 11762887 51 + 1.833 1.788 -0.149
ENSG00000005302 E048 91.3694242 0.0004630007 0.0392199820 0.152743063 X 11762888 11762997 110 + 1.985 1.922 -0.210
ENSG00000005302 E049 101.0516413 0.0004861676 0.3405614131 0.578513592 X 11763780 11763938 159 + 2.007 1.988 -0.064
ENSG00000005302 E050 39.0972495 0.1323028319 0.4175106590 0.641729318 X 11763939 11765192 1254 + 1.457 1.734 0.947
ENSG00000005302 E051 17.0767292 0.0787596665 0.1843083608 0.409576011 X 11765193 11765466 274 + 1.109 1.384 0.969
ENSG00000005302 E052 35.6252267 0.0013265763 0.2959530758 0.536457595 X 11765467 11765469 3 + 1.519 1.596 0.265
ENSG00000005302 E053 55.4064661 0.0021924249 0.0776869180 0.240161384 X 11765470 11765521 52 + 1.694 1.801 0.361
ENSG00000005302 E054 44.3302267 0.0025087590 0.0473583119 0.173412301 X 11765522 11765537 16 + 1.589 1.717 0.435
ENSG00000005302 E055 59.2419043 0.0009001511 0.0028927828 0.022757264 X 11765538 11765597 60 + 1.703 1.856 0.516
ENSG00000005302 E056 79.7255537 0.0102571766 0.1059142032 0.292190580 X 11765598 11765729 132 + 1.850 1.962 0.377
ENSG00000005302 E057 37.6739229 0.0077339782 0.6226251946 0.785592808 X 11765730 11766960 1231 + 1.589 1.574 -0.051
ENSG00000005302 E058 11.9406315 0.0275905725 0.4580726067 0.671789980 X 11766961 11767046 86 + 1.055 1.170 0.411
ENSG00000005302 E059 8.2198723 0.0044132422 0.5529043862 0.738302864 X 11767047 11767052 6 + 0.989 0.935 -0.202
ENSG00000005302 E060 14.4162560 0.0024313917 0.5959041316 0.767686525 X 11767053 11767144 92 + 1.159 1.220 0.218
ENSG00000005302 E061 11.3939544 0.0207551326 0.2572029773 0.495974442 X 11767145 11767169 25 + 1.025 1.174 0.539
ENSG00000005302 E062 15.5621144 0.0022058280 0.4774602419 0.685361350 X 11767170 11767286 117 + 1.183 1.258 0.265
ENSG00000005302 E063 24.6543944 0.0213732521 0.4004642242 0.628687389 X 11767287 11767818 532 + 1.365 1.464 0.343
ENSG00000005302 E064 6.2624233 0.0063882776 0.6750454554 0.819576367 X 11767819 11767862 44 + 0.829 0.894 0.249
ENSG00000005302 E065 19.4164189 0.0112999613 0.5010394212 0.701520209 X 11767863 11768572 710 + 1.267 1.350 0.290
ENSG00000005302 E066 41.3724729 0.0011487236 0.4531483376 0.668061477 X 11768573 11768574 2 + 1.591 1.648 0.192
ENSG00000005302 E067 58.5459340 0.0008221350 0.8806580511 0.941580837 X 11768575 11768621 47 + 1.757 1.778 0.073
ENSG00000005302 E068 65.6500388 0.0029550202 0.8290084130 0.913262590 X 11768622 11768682 61 + 1.817 1.820 0.010
ENSG00000005302 E069 9.3268556 0.0576399768 0.7122806896 0.843230229 X 11768683 11769102 420 + 0.974 1.064 0.331
ENSG00000005302 E070 64.0516218 0.0008257965 0.2381458976 0.474492552 X 11772156 11772255 100 + 1.775 1.842 0.227
ENSG00000005302 E071 61.6490276 0.0151332447 0.4395209750 0.658300735 X 11772621 11772705 85 + 1.756 1.828 0.244
ENSG00000005302 E072 215.6352641 0.0099687859 0.0455335032 0.168875478 X 11774980 11775772 793 + 2.278 2.392 0.380