ENSG00000004766

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251739 ENSG00000004766 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS50 protein_coding protein_coding 8.627536 1.46899 18.44787 0.2122904 1.176811 3.641552 1.4317297 0.03038267 3.3103792 0.03038267 0.16081692 6.3614678 0.10450000 0.01610000 0.18046667 0.16436667 0.0009676164 0.0009676164 FALSE TRUE
ENST00000305866 ENSG00000004766 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS50 protein_coding protein_coding 8.627536 1.46899 18.44787 0.2122904 1.176811 3.641552 3.1488506 0.75579718 6.4552826 0.05300588 0.16074504 3.0776792 0.43118333 0.54016667 0.35230000 -0.18786667 0.4828124078 0.0009676164 FALSE TRUE
ENST00000443443 ENSG00000004766 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS50 protein_coding protein_coding 8.627536 1.46899 18.44787 0.2122904 1.176811 3.641552 0.4381510 0.00000000 0.8143003 0.00000000 0.23635194 6.3650982 0.06171250 0.00000000 0.04626667 0.04626667 0.1266144525 0.0009676164 FALSE TRUE
ENST00000458707 ENSG00000004766 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS50 protein_coding protein_coding 8.627536 1.46899 18.44787 0.2122904 1.176811 3.641552 0.5379299 0.25164552 0.8937962 0.05584049 0.07272296 1.7883840 0.10690000 0.17473333 0.04903333 -0.12570000 0.0295248551 0.0009676164 FALSE TRUE
ENST00000474412 ENSG00000004766 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS50 protein_coding processed_transcript 8.627536 1.46899 18.44787 0.2122904 1.176811 3.641552 0.8236379 0.21244756 1.8661236 0.21244756 0.50640393 3.0762177 0.09189583 0.11256667 0.10033333 -0.01223333 0.8007822450 0.0009676164 TRUE FALSE
ENST00000476413 ENSG00000004766 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS50 protein_coding retained_intron 8.627536 1.46899 18.44787 0.2122904 1.176811 3.641552 0.4476008 0.00000000 1.3797386 0.00000000 1.37973861 7.1186697 0.02553333 0.00000000 0.07120000 0.07120000 0.9859918323 0.0009676164   FALSE
ENST00000484954 ENSG00000004766 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS50 protein_coding retained_intron 8.627536 1.46899 18.44787 0.2122904 1.176811 3.641552 0.8845932 0.00000000 2.3013592 0.00000000 0.69795848 7.8525977 0.05633333 0.00000000 0.12313333 0.12313333 0.0023895216 0.0009676164 FALSE FALSE
ENST00000485140 ENSG00000004766 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS50 protein_coding retained_intron 8.627536 1.46899 18.44787 0.2122904 1.176811 3.641552 0.1118987 0.10305561 0.2117085 0.05401785 0.08095153 0.9716311 0.01566250 0.06413333 0.01123333 -0.05290000 0.2593929047 0.0009676164 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000004766 E001 0.7507353 0.0428932142 0.7548584108   7 93232340 93232365 26 + 0.198 0.000 -11.200
ENSG00000004766 E002 0.7507353 0.0428932142 0.7548584108   7 93232366 93232368 3 + 0.198 0.000 -13.280
ENSG00000004766 E003 0.7507353 0.0428932142 0.7548584108   7 93232369 93232371 3 + 0.198 0.000 -13.280
ENSG00000004766 E004 2.3770345 0.0150022830 0.1188017455 0.313902470 7 93232372 93232374 3 + 0.437 0.000 -14.703
ENSG00000004766 E005 2.3770345 0.0150022830 0.1188017455 0.313902470 7 93232375 93232375 1 + 0.437 0.000 -14.703
ENSG00000004766 E006 19.7282507 0.0055379611 0.3825054090 0.614238857 7 93232376 93232427 52 + 1.146 1.037 -0.395
ENSG00000004766 E007 26.3574169 0.0096945250 0.3689937868 0.603210043 7 93232428 93232500 73 + 1.263 1.160 -0.364
ENSG00000004766 E008 30.3715377 0.0110627907 0.2135476643 0.445837390 7 93239866 93239934 69 + 1.325 1.185 -0.491
ENSG00000004766 E009 0.1426347 0.0320452226 0.7122203317   7 93239935 93239950 16 + 0.048 0.000 -11.122
ENSG00000004766 E010 0.0000000       7 93240716 93240818 103 +      
ENSG00000004766 E011 0.6294705 0.0232194501 0.4222400091   7 93246102 93246129 28 + 0.130 0.278 1.369
ENSG00000004766 E012 37.6016304 0.0010320300 0.0182839794 0.089969872 7 93252653 93252775 123 + 1.421 1.187 -0.818
ENSG00000004766 E013 19.9059687 0.0020128230 0.0105790901 0.060578374 7 93253860 93253862 3 + 1.169 0.806 -1.352
ENSG00000004766 E014 34.2514387 0.0019679558 0.0185637943 0.090944529 7 93253863 93253931 69 + 1.383 1.133 -0.879
ENSG00000004766 E015 0.0000000       7 93256430 93256508 79 +      
ENSG00000004766 E016 32.4857765 0.0039906580 0.0647160577 0.213262605 7 93256509 93256562 54 + 1.359 1.161 -0.700
ENSG00000004766 E017 39.5311298 0.0071817158 0.0319569082 0.133093438 7 93257394 93257464 71 + 1.439 1.212 -0.793
ENSG00000004766 E018 1.3731913 0.0699332849 0.3479710572   7 93257465 93257765 301 + 0.308 0.000 -13.957
ENSG00000004766 E019 1.2681187 0.0132041938 0.3760555144   7 93258109 93258158 50 + 0.285 0.000 -13.954
ENSG00000004766 E020 48.9086831 0.0025437057 0.4872069609 0.692043901 7 93258159 93258276 118 + 1.517 1.460 -0.196
ENSG00000004766 E021 2.8606123 0.0108761668 0.4067836384 0.633603114 7 93258277 93258356 80 + 0.472 0.279 -1.127
ENSG00000004766 E022 31.8586004 0.0016004903 0.5022099708 0.702298126 7 93258357 93258392 36 + 1.328 1.387 0.205
ENSG00000004766 E023 0.1614157 0.0363769339 0.7142285145   7 93259415 93259549 135 + 0.048 0.000 -11.107
ENSG00000004766 E024 31.0822248 0.0013854090 0.3140710254 0.554312299 7 93259550 93259613 64 + 1.313 1.402 0.309
ENSG00000004766 E025 16.7862398 0.0075443961 0.7215618063 0.849099474 7 93259614 93259632 19 + 1.080 1.035 -0.162
ENSG00000004766 E026 0.1723744 0.0324972326 0.0405017471   7 93271066 93271219 154 + 0.000 0.279 14.437
ENSG00000004766 E027 26.2072235 0.0013216573 0.9573295636 0.980511064 7 93271220 93271262 43 + 1.253 1.257 0.015
ENSG00000004766 E028 41.1164612 0.0008526181 0.0864691704 0.257366248 7 93272635 93272733 99 + 1.454 1.298 -0.539
ENSG00000004766 E029 0.1308682 0.0308954397 0.0406303598   7 93272734 93273488 755 + 0.000 0.278 14.450
ENSG00000004766 E030 1.9089077 0.0124423364 0.0464244016 0.171081118 7 93275842 93276164 323 + 0.284 0.663 1.960
ENSG00000004766 E031 54.2178041 0.0006898175 0.2458687427 0.483433686 7 93276165 93276305 141 + 1.563 1.474 -0.305
ENSG00000004766 E032 0.4764247 0.0217681645 0.2763119196   7 93276306 93276428 123 + 0.090 0.279 1.959
ENSG00000004766 E033 53.1536079 0.0006929006 0.1593158165 0.375724608 7 93291703 93291835 133 + 1.557 1.447 -0.379
ENSG00000004766 E034 38.8615483 0.0011252679 0.0373669561 0.147915355 7 93294545 93294636 92 + 1.434 1.235 -0.693
ENSG00000004766 E035 0.0000000       7 93295415 93295431 17 +      
ENSG00000004766 E036 27.6232222 0.0015953603 0.5175419175 0.713333396 7 93296742 93296836 95 + 1.280 1.212 -0.241
ENSG00000004766 E037 0.0000000       7 93296837 93296959 123 +      
ENSG00000004766 E038 37.2354329 0.0011482056 0.3392381654 0.577328366 7 93297145 93297243 99 + 1.405 1.317 -0.306
ENSG00000004766 E039 39.1775006 0.0093071044 0.5712968996 0.751265766 7 93303460 93303550 91 + 1.424 1.369 -0.189
ENSG00000004766 E040 70.8481673 0.0007628924 0.7186656587 0.847358959 7 93305828 93306004 177 + 1.665 1.687 0.073
ENSG00000004766 E041 55.5200141 0.0007294184 0.1531158651 0.366772768 7 93308824 93308942 119 + 1.550 1.645 0.324
ENSG00000004766 E042 50.1784466 0.0009371165 0.7716204601 0.879556066 7 93311166 93311272 107 + 1.515 1.535 0.069
ENSG00000004766 E043 3.9477920 0.1042087914 0.0017156190 0.015127288 7 93320376 93320852 477 + 0.401 1.011 2.609
ENSG00000004766 E044 1.9814437 0.0389080717 0.0016474990 0.014651404 7 93320853 93321170 318 + 0.229 0.806 2.956
ENSG00000004766 E045 0.4349185 0.0217681645 0.2773037999   7 93323250 93323610 361 + 0.090 0.278 1.956
ENSG00000004766 E046 52.8201164 0.0008043191 0.7656964548 0.876084189 7 93323611 93323732 122 + 1.537 1.557 0.068
ENSG00000004766 E047 0.1426347 0.0320452226 0.7122203317   7 93333899 93333925 27 + 0.048 0.000 -11.122
ENSG00000004766 E048 49.7663244 0.0046031050 0.1557541029 0.370576362 7 93334117 93334197 81 + 1.504 1.609 0.357
ENSG00000004766 E049 0.2922838 0.0274716698 0.1387709170   7 93340598 93340870 273 + 0.048 0.278 2.954
ENSG00000004766 E050 59.9970148 0.0009933533 0.1904737219 0.417566887 7 93341427 93341575 149 + 1.587 1.671 0.287
ENSG00000004766 E051 42.6234309 0.0009192901 0.5042272126 0.703738554 7 93348711 93348807 97 + 1.448 1.499 0.175
ENSG00000004766 E052 28.9053750 0.0016448586 0.8762378315 0.939339791 7 93349875 93349878 4 + 1.295 1.278 -0.060
ENSG00000004766 E053 33.9476781 0.0026466956 0.6260820593 0.788006060 7 93349879 93349897 19 + 1.366 1.317 -0.168
ENSG00000004766 E054 57.8136135 0.0020242976 0.9279439706 0.966004838 7 93349898 93350033 136 + 1.584 1.588 0.016
ENSG00000004766 E055 46.8044155 0.0009372990 0.3182917017 0.558193767 7 93353640 93353761 122 + 1.484 1.557 0.249
ENSG00000004766 E056 57.8725210 0.0021450096 0.0028842180 0.022711783 7 93355891 93356080 190 + 1.557 1.747 0.648
ENSG00000004766 E057 0.6434498 0.0193874923 1.0000000000   7 93356081 93356186 106 + 0.165 0.000 -13.058
ENSG00000004766 E058 134.9512402 0.0003518827 0.0004851213 0.005539588 7 93358317 93361123 2807 + 1.925 2.068 0.480