ENSG00000004487

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356634 ENSG00000004487 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM1A protein_coding protein_coding 110.2057 114.9455 96.13623 31.70301 3.041702 -0.2577738 56.113577 47.111937 68.3632012 12.755495 5.8671793 0.53703214 0.53178333 0.41250000 0.70886667 0.29636667 0.001329115 0.001329115 FALSE TRUE
ENST00000494920 ENSG00000004487 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM1A protein_coding protein_coding 110.2057 114.9455 96.13623 31.70301 3.041702 -0.2577738 23.816364 37.477430 0.4386046 11.699623 0.4386046 -6.38481875 0.18706250 0.31656667 0.00440000 -0.31216667 0.003145372 0.001329115 FALSE TRUE
ENST00000685102 ENSG00000004487 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM1A protein_coding protein_coding 110.2057 114.9455 96.13623 31.70301 3.041702 -0.2577738 6.544559 5.406792 5.5765866 1.542492 0.1145378 0.04452826 0.06299167 0.04653333 0.05820000 0.01166667 0.578362669 0.001329115 FALSE TRUE
MSTRG.523.28 ENSG00000004487 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM1A protein_coding   110.2057 114.9455 96.13623 31.70301 3.041702 -0.2577738 7.194460 12.398721 4.9631703 4.816455 2.7180676 -1.31911665 0.06020000 0.10210000 0.05333333 -0.04876667 0.804837884 0.001329115 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000004487 E001 1.3606169 0.0921746502 3.162924e-01   1 23019443 23019447 5 + 0.483 0.279 -1.179
ENSG00000004487 E002 4.3061084 0.1308608751 6.102796e-01 7.770943e-01 1 23019448 23019467 20 + 0.676 0.792 0.473
ENSG00000004487 E003 6.5694248 0.0305756666 5.989750e-01 7.695576e-01 1 23019468 23019479 12 + 0.854 0.928 0.283
ENSG00000004487 E004 102.2732295 0.0158773895 8.881235e-01 9.456502e-01 1 23019480 23019671 192 + 2.025 2.007 -0.059
ENSG00000004487 E005 226.6027497 0.0164511762 6.654488e-01 8.133201e-01 1 23019672 23019947 276 + 2.380 2.337 -0.144
ENSG00000004487 E006 435.0718549 0.0084441583 1.867004e-02 9.129551e-02 1 23030469 23030634 166 + 2.703 2.574 -0.430
ENSG00000004487 E007 103.1458403 0.0101977860 2.337918e-01 4.695537e-01 1 23044427 23044486 60 + 2.062 1.974 -0.297
ENSG00000004487 E008 311.6538009 0.0002967652 1.061762e-03 1.038542e-02 1 23050387 23050424 38 + 2.533 2.461 -0.241
ENSG00000004487 E009 470.5776729 0.0001475061 2.007980e-12 1.958651e-10 1 23050425 23050520 96 + 2.734 2.613 -0.403
ENSG00000004487 E010 476.8259397 0.0001472437 5.005992e-13 5.439108e-11 1 23053761 23053839 79 + 2.740 2.617 -0.410
ENSG00000004487 E011 5.5915216 0.0063963263 2.811678e-07 9.316615e-06 1 23053840 23055068 1229 + 1.078 0.345 -3.175
ENSG00000004487 E012 548.1313816 0.0009568996 1.689754e-09 9.451879e-08 1 23055069 23055161 93 + 2.804 2.676 -0.424
ENSG00000004487 E013 1.0705460 0.0153787590 2.027475e-01   1 23055162 23055418 257 + 0.433 0.206 -1.494
ENSG00000004487 E014 655.2887405 0.0002369965 5.712549e-18 1.312750e-15 1 23055932 23056038 107 + 2.884 2.750 -0.447
ENSG00000004487 E015 17.0916575 0.0318299573 5.316589e-04 5.964322e-03 1 23056039 23057483 1445 + 1.435 0.997 -1.553
ENSG00000004487 E016 634.0084797 0.0002104020 7.271069e-14 9.312177e-12 1 23057484 23057565 82 + 2.861 2.744 -0.389
ENSG00000004487 E017 386.4790481 0.0002792770 6.210254e-12 5.562469e-10 1 23059073 23059075 3 + 2.656 2.521 -0.449
ENSG00000004487 E018 728.4954787 0.0007488282 3.955263e-13 4.387294e-11 1 23059076 23059167 92 + 2.930 2.795 -0.448
ENSG00000004487 E019 3.6401409 0.1437970105 4.735396e-02 1.734041e-01 1 23065199 23066059 861 + 0.855 0.399 -2.030
ENSG00000004487 E020 0.8206259 0.0264667415 5.733742e-01   1 23066060 23066071 12 + 0.307 0.206 -0.762
ENSG00000004487 E021 4.0573057 0.2003614752 1.167226e-01 3.103595e-01 1 23068170 23068538 369 + 0.860 0.463 -1.712
ENSG00000004487 E022 885.8573106 0.0004313395 1.177201e-17 2.543457e-15 1 23068539 23068681 143 + 3.013 2.881 -0.437
ENSG00000004487 E023 1.5466402 0.4628449610 6.951140e-01 8.323497e-01 1 23068682 23069060 379 + 0.308 0.464 0.892
ENSG00000004487 E024 701.3224122 0.0001179872 5.421265e-19 1.378227e-16 1 23069061 23069151 91 + 2.909 2.783 -0.418
ENSG00000004487 E025 20.6611199 0.0862576677 4.010336e-02 1.549757e-01 1 23069152 23070853 1702 + 1.489 1.126 -1.269
ENSG00000004487 E026 9.1471882 0.0192183386 9.825438e-05 1.473755e-03 1 23070854 23071224 371 + 1.205 0.696 -1.925
ENSG00000004487 E027 679.6151093 0.0004410650 2.579500e-04 3.303359e-03 1 23071225 23071356 132 + 2.865 2.802 -0.210
ENSG00000004487 E028 352.1984349 0.0001897028 1.468381e-02 7.690750e-02 1 23071357 23071359 3 + 2.574 2.525 -0.165
ENSG00000004487 E029 4.2736919 0.0058921259 3.868549e-01 6.179862e-01 1 23071360 23072123 764 + 0.646 0.768 0.505
ENSG00000004487 E030 539.3239616 0.0001174883 1.293087e-01 3.306519e-01 1 23072124 23072197 74 + 2.745 2.719 -0.085
ENSG00000004487 E031 9.1460465 0.0037414530 5.216776e-02 1.847917e-01 1 23073274 23073291 18 + 0.876 1.088 0.789
ENSG00000004487 E032 721.1720083 0.0010947984 3.274274e-02 1.353341e-01 1 23073292 23073403 112 + 2.832 2.875 0.144
ENSG00000004487 E033 7.3426903 0.1633348246 6.427886e-01 7.986836e-01 1 23074463 23075666 1204 + 0.976 0.861 -0.436
ENSG00000004487 E034 10.5137453 0.1131096488 2.589137e-01 4.977529e-01 1 23075667 23076782 1116 + 1.178 0.907 -0.994
ENSG00000004487 E035 4.7702347 0.1297163179 8.623983e-02 2.568895e-01 1 23076783 23077227 445 + 0.915 0.542 -1.540
ENSG00000004487 E036 395.9442315 0.0029856637 9.602200e-01 9.819554e-01 1 23077228 23077233 6 + 2.595 2.597 0.005
ENSG00000004487 E037 868.5864078 0.0011363589 8.453100e-06 1.813684e-04 1 23077234 23077360 127 + 2.885 2.977 0.304
ENSG00000004487 E038 49.5883285 0.1783402573 2.270390e-01 4.618184e-01 1 23077361 23078965 1605 + 1.828 1.554 -0.931
ENSG00000004487 E039 6.9518871 0.0968870660 4.296827e-01 6.507949e-01 1 23078966 23078989 24 + 0.983 0.810 -0.661
ENSG00000004487 E040 485.8478680 0.0001480913 1.145440e-17 2.484317e-15 1 23078990 23079012 23 + 2.603 2.747 0.480
ENSG00000004487 E041 1128.4355256 0.0000953298 4.118943e-21 1.382141e-18 1 23079013 23079177 165 + 2.992 3.096 0.346
ENSG00000004487 E042 4.9092310 0.2144868503 3.046496e-01 5.452314e-01 1 23079363 23079552 190 + 0.906 0.580 -1.330
ENSG00000004487 E043 955.1675486 0.0002811361 3.139615e-08 1.313896e-06 1 23079553 23079667 115 + 2.936 3.011 0.251
ENSG00000004487 E044 30.0527548 0.2321545924 4.806360e-01 6.875140e-01 1 23079668 23080872 1205 + 1.560 1.417 -0.491
ENSG00000004487 E045 19.0640698 0.1277302434 7.455743e-01 8.640495e-01 1 23080873 23081445 573 + 1.338 1.261 -0.270
ENSG00000004487 E046 924.0435014 0.0009095468 5.390031e-08 2.133933e-06 1 23081446 23081573 128 + 2.906 3.008 0.339
ENSG00000004487 E047 17.5586344 0.2268791035 6.262222e-01 7.880528e-01 1 23081574 23082219 646 + 1.320 1.212 -0.378
ENSG00000004487 E048 692.8921840 0.0018146705 1.396386e-07 5.014559e-06 1 23082220 23082292 73 + 2.761 2.896 0.449
ENSG00000004487 E049 715.0248059 0.0001527626 2.210073e-25 1.172879e-22 1 23082293 23082355 63 + 2.768 2.916 0.494
ENSG00000004487 E050 491.4564741 0.0001157133 3.023267e-14 4.130493e-12 1 23082356 23082366 11 + 2.620 2.745 0.415
ENSG00000004487 E051 18.3265827 0.1638893825 2.808586e-01 5.211053e-01 1 23082367 23082449 83 + 1.392 1.164 -0.798
ENSG00000004487 E052 29.9124230 0.0639088755 5.884365e-01 7.626444e-01 1 23082450 23082509 60 + 1.543 1.435 -0.370
ENSG00000004487 E053 111.8487886 0.0435079404 8.308673e-01 9.142771e-01 1 23082510 23083178 669 + 2.079 2.025 -0.181
ENSG00000004487 E054 1516.5134972 0.0001024907 1.905386e-44 4.622547e-41 1 23083179 23083689 511 + 3.100 3.238 0.458
ENSG00000004487 E055 2.1681573 0.0189501259 5.311958e-01 7.228989e-01 1 23083690 23089457 5768 + 0.433 0.537 0.514