ENSG00000003393

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000467448 ENSG00000003393 HEK293_OSMI2_6hA HEK293_TMG_6hB ALS2 protein_coding protein_coding 7.467001 5.092454 10.54839 0.5288319 0.596583 1.049127 1.1803935 0.6502269 1.89264869 0.32567094 0.19868540 1.5269754 0.1444375 0.11643333 0.178733333 0.06230000 0.811968956 0.001387131 FALSE TRUE
ENST00000679686 ENSG00000003393 HEK293_OSMI2_6hA HEK293_TMG_6hB ALS2 protein_coding processed_transcript 7.467001 5.092454 10.54839 0.5288319 0.596583 1.049127 2.5280373 1.1690316 4.39018120 0.09291895 0.21217577 1.8999605 0.3128667 0.23113333 0.416833333 0.18570000 0.001387131 0.001387131 FALSE TRUE
ENST00000680135 ENSG00000003393 HEK293_OSMI2_6hA HEK293_TMG_6hB ALS2 protein_coding nonsense_mediated_decay 7.467001 5.092454 10.54839 0.5288319 0.596583 1.049127 0.1698069 0.4710591 0.37351166 0.23775840 0.37351166 -0.3269436 0.0219625 0.08413333 0.033200000 -0.05093333 0.681127416 0.001387131 FALSE TRUE
ENST00000680634 ENSG00000003393 HEK293_OSMI2_6hA HEK293_TMG_6hB ALS2 protein_coding processed_transcript 7.467001 5.092454 10.54839 0.5288319 0.596583 1.049127 0.6810509 1.1548745 0.08556029 0.24818926 0.08556029 -3.6076195 0.1213667 0.22110000 0.009133333 -0.21196667 0.008934524 0.001387131 FALSE TRUE
ENST00000681619 ENSG00000003393 HEK293_OSMI2_6hA HEK293_TMG_6hB ALS2 protein_coding protein_coding 7.467001 5.092454 10.54839 0.5288319 0.596583 1.049127 0.4364796 0.0000000 0.38219549 0.00000000 0.21207905 5.2935011 0.0544375 0.00000000 0.036866667 0.03686667 0.437985608 0.001387131 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000003393 E001 0.1426347 0.0317127253 9.700757e-01   2 201700267 201700513 247 - 0.090 0.000 -9.598
ENSG00000003393 E002 0.3150090 0.0279213913 6.267042e-01   2 201700514 201700559 46 - 0.090 0.162 0.971
ENSG00000003393 E003 0.1723744 0.0346486894 2.533886e-01   2 201700560 201700560 1 - 0.000 0.162 13.105
ENSG00000003393 E004 0.1723744 0.0346486894 2.533886e-01   2 201700561 201700561 1 - 0.000 0.162 13.105
ENSG00000003393 E005 1.3026600 0.0143451066 5.817804e-01   2 201700562 201700564 3 - 0.378 0.279 -0.619
ENSG00000003393 E006 1.6232785 0.0137336885 3.324093e-01 5.711846e-01 2 201700565 201700565 1 - 0.454 0.279 -1.034
ENSG00000003393 E007 4.1428391 0.0120321182 3.280034e-01 5.670119e-01 2 201700566 201700566 1 - 0.627 0.776 0.618
ENSG00000003393 E008 4.5887163 0.0064384459 1.901280e-01 4.170998e-01 2 201700567 201700591 25 - 0.650 0.837 0.761
ENSG00000003393 E009 4.5887163 0.0064384459 1.901280e-01 4.170998e-01 2 201700592 201700593 2 - 0.650 0.837 0.761
ENSG00000003393 E010 9.9348072 0.0053706212 4.003540e-02 1.548228e-01 2 201700594 201700636 43 - 0.924 1.149 0.824
ENSG00000003393 E011 42.7300985 0.0008556298 5.826827e-04 6.426349e-03 2 201700637 201700800 164 - 1.543 1.734 0.651
ENSG00000003393 E012 34.2431931 0.0010581606 1.572086e-04 2.186002e-03 2 201700801 201700848 48 - 1.432 1.664 0.793
ENSG00000003393 E013 88.5667150 0.0037947606 3.794134e-06 9.075088e-05 2 201700849 201701138 290 - 1.840 2.063 0.750
ENSG00000003393 E014 80.3740370 0.0055912839 4.156293e-03 3.002783e-02 2 201701139 201701541 403 - 1.826 1.985 0.534
ENSG00000003393 E015 11.8563776 0.0031347583 3.134076e-03 2.421217e-02 2 201701542 201701554 13 - 0.968 1.259 1.047
ENSG00000003393 E016 50.6633705 0.0020244224 3.694015e-01 6.035575e-01 2 201701555 201701789 235 - 1.669 1.723 0.183
ENSG00000003393 E017 22.7280851 0.0162495686 6.383348e-01 7.959307e-01 2 201701790 201701794 5 - 1.335 1.381 0.159
ENSG00000003393 E018 44.0788535 0.0024124314 7.658637e-01 8.761521e-01 2 201701795 201701889 95 - 1.620 1.643 0.078
ENSG00000003393 E019 8.6404939 0.2302556164 6.779854e-01 8.214334e-01 2 201701890 201704121 2232 - 0.962 0.956 -0.022
ENSG00000003393 E020 42.4446753 0.0036078491 3.627337e-01 5.979390e-01 2 201704122 201704218 97 - 1.590 1.652 0.210
ENSG00000003393 E021 1.7788971 0.0109125132 8.783614e-01 9.404812e-01 2 201704219 201704240 22 - 0.418 0.448 0.160
ENSG00000003393 E022 2.6904279 0.0089349390 6.894498e-01 8.286770e-01 2 201704241 201704453 213 - 0.576 0.513 -0.295
ENSG00000003393 E023 46.9923579 0.0059675095 1.045137e-01 2.898052e-01 2 201704454 201704583 130 - 1.617 1.724 0.364
ENSG00000003393 E024 24.2829220 0.0085655501 1.400484e-01 3.475687e-01 2 201704584 201704603 20 - 1.332 1.457 0.432
ENSG00000003393 E025 0.8108349 0.0182595837 4.993899e-01   2 201704604 201704806 203 - 0.284 0.162 -1.028
ENSG00000003393 E026 32.9870783 0.0160200861 8.465436e-02 2.540439e-01 2 201705139 201705200 62 - 1.451 1.600 0.510
ENSG00000003393 E027 24.4297457 0.0063113795 1.041115e-01 2.889920e-01 2 201705416 201705461 46 - 1.332 1.464 0.456
ENSG00000003393 E028 1.3650427 0.0622050158 9.784433e-01   2 201705462 201706845 1384 - 0.377 0.370 -0.037
ENSG00000003393 E029 43.6092723 0.0008260609 4.160335e-02 1.588957e-01 2 201706846 201707022 177 - 1.581 1.697 0.394
ENSG00000003393 E030 31.9019833 0.0051855417 4.696703e-02 1.724857e-01 2 201707869 201707991 123 - 1.446 1.589 0.492
ENSG00000003393 E031 32.0953474 0.0014406971 7.275658e-02 2.303070e-01 2 201709881 201710038 158 - 1.450 1.570 0.409
ENSG00000003393 E032 34.9365073 0.0010071760 9.513709e-01 9.776747e-01 2 201710991 201711108 118 - 1.528 1.537 0.029
ENSG00000003393 E033 13.0509690 0.0036341571 2.690316e-01 5.088114e-01 2 201711109 201713139 2031 - 1.164 1.056 -0.388
ENSG00000003393 E034 0.1723744 0.0346486894 2.533886e-01   2 201713343 201713345 3 - 0.000 0.162 13.105
ENSG00000003393 E035 2.3182183 0.4630138752 5.272312e-01 7.200089e-01 2 201713346 201713757 412 - 0.564 0.378 -0.940
ENSG00000003393 E036 7.2206266 0.0119751473 5.109740e-02 1.823007e-01 2 201713758 201715171 1414 - 0.969 0.704 -1.032
ENSG00000003393 E037 0.5365243 0.0220657687 2.545338e-01   2 201715172 201715178 7 - 0.090 0.280 1.972
ENSG00000003393 E038 48.9700627 0.0016789056 4.995583e-01 7.004715e-01 2 201715672 201715836 165 - 1.684 1.651 -0.111
ENSG00000003393 E039 18.3951606 0.0748327489 4.628132e-01 6.750116e-01 2 201715837 201715839 3 - 1.297 1.183 -0.402
ENSG00000003393 E040 0.4458772 0.0217681645 2.556413e-01   2 201716590 201716641 52 - 0.090 0.279 1.968
ENSG00000003393 E041 0.1308682 0.0309932847 2.543365e-01   2 201716642 201716687 46 - 0.000 0.161 13.117
ENSG00000003393 E042 0.1308682 0.0309932847 2.543365e-01   2 201716688 201716711 24 - 0.000 0.161 13.117
ENSG00000003393 E043 48.0646620 0.0038338590 1.894880e-01 4.163094e-01 2 201718077 201718210 134 - 1.689 1.615 -0.250
ENSG00000003393 E044 3.6578928 0.0073861733 7.983160e-02 2.444854e-01 2 201718211 201719985 1775 - 0.731 0.448 -1.281
ENSG00000003393 E045 1.1608332 0.0168706851 3.186923e-02   2 201719986 201720128 143 - 0.418 0.000 -14.609
ENSG00000003393 E046 2.1771788 0.0114856850 1.354578e-01 3.404877e-01 2 201720129 201720442 314 - 0.549 0.280 -1.491
ENSG00000003393 E047 0.7013366 0.0524820241 7.073075e-01   2 201720443 201720489 47 - 0.229 0.162 -0.614
ENSG00000003393 E048 0.0000000       2 201721990 201722057 68 -      
ENSG00000003393 E049 0.2735028 0.0260505586 6.293097e-01   2 201722058 201722113 56 - 0.090 0.162 0.967
ENSG00000003393 E050 0.4349185 0.0217681645 1.000000e+00   2 201722114 201722123 10 - 0.165 0.162 -0.033
ENSG00000003393 E051 5.4745944 0.0052415238 7.454907e-01 8.639956e-01 2 201722124 201723042 919 - 0.815 0.775 -0.157
ENSG00000003393 E052 37.1367647 0.0009600696 1.546273e-01 3.688824e-01 2 201723043 201723120 78 - 1.584 1.501 -0.283
ENSG00000003393 E053 40.7897391 0.0020611817 1.440849e-01 3.535135e-01 2 201723330 201723441 112 - 1.626 1.542 -0.285
ENSG00000003393 E054 45.1683871 0.0027777204 1.977483e-01 4.267931e-01 2 201724295 201724459 165 - 1.665 1.595 -0.239
ENSG00000003393 E055 38.8999032 0.0009609376 1.158569e-01 3.089093e-01 2 201725356 201725454 99 - 1.609 1.519 -0.307
ENSG00000003393 E056 1.2922489 0.0172090503 5.903995e-01   2 201725455 201726483 1029 - 0.377 0.280 -0.615
ENSG00000003393 E057 32.1077732 0.0010763564 2.728888e-02 1.191446e-01 2 201726484 201726549 66 - 1.540 1.397 -0.493
ENSG00000003393 E058 0.1723744 0.0346486894 2.533886e-01   2 201726550 201726663 114 - 0.000 0.162 13.105
ENSG00000003393 E059 48.4804872 0.0008891248 5.580217e-02 1.931770e-01 2 201726664 201726866 203 - 1.704 1.605 -0.337
ENSG00000003393 E060 0.0000000       2 201726867 201727211 345 -      
ENSG00000003393 E061 25.8314948 0.0053670633 9.836780e-01 9.936660e-01 2 201727212 201727278 67 - 1.406 1.411 0.017
ENSG00000003393 E062 1.8052065 0.5162542207 4.915281e-01 6.950100e-01 2 201727279 201727700 422 - 0.491 0.284 -1.187
ENSG00000003393 E063 0.1426347 0.0317127253 9.700757e-01   2 201727701 201727704 4 - 0.090 0.000 -11.974
ENSG00000003393 E064 24.2578910 0.0017283997 2.629244e-01 5.021341e-01 2 201727705 201727775 71 - 1.355 1.441 0.296
ENSG00000003393 E065 0.0000000       2 201727776 201728511 736 -      
ENSG00000003393 E066 29.8233929 0.0014435698 6.672285e-01 8.144505e-01 2 201728512 201728617 106 - 1.461 1.494 0.115
ENSG00000003393 E067 18.8274866 0.0021642752 8.190454e-01 9.074836e-01 2 201728618 201728640 23 - 1.284 1.269 -0.050
ENSG00000003393 E068 0.0000000       2 201728641 201729051 411 -      
ENSG00000003393 E069 31.2399933 0.0010689559 4.495207e-01 6.653328e-01 2 201729052 201729183 132 - 1.501 1.455 -0.155
ENSG00000003393 E070 0.0000000       2 201729184 201729563 380 -      
ENSG00000003393 E071 1.6376178 0.0117814404 7.932596e-01 8.923093e-01 2 201733050 201733275 226 - 0.417 0.372 -0.251
ENSG00000003393 E072 32.6670373 0.0016172965 8.359179e-01 9.171285e-01 2 201733276 201733438 163 - 1.504 1.495 -0.029
ENSG00000003393 E073 0.0000000       2 201738538 201738669 132 -      
ENSG00000003393 E074 22.8297513 0.0034072909 6.247262e-01 7.871734e-01 2 201738670 201738735 66 - 1.364 1.329 -0.120
ENSG00000003393 E075 0.0000000       2 201738736 201738978 243 -      
ENSG00000003393 E076 0.1426347 0.0317127253 9.700757e-01   2 201738979 201739026 48 - 0.090 0.000 -11.974
ENSG00000003393 E077 0.3040503 0.0244411696 4.488402e-01   2 201739027 201739068 42 - 0.165 0.000 -12.938
ENSG00000003393 E078 0.3040503 0.0244411696 4.488402e-01   2 201739069 201739219 151 - 0.165 0.000 -12.938
ENSG00000003393 E079 0.3040503 0.0244411696 4.488402e-01   2 201740610 201740624 15 - 0.165 0.000 -12.938
ENSG00000003393 E080 0.4654660 0.0234550735 2.454118e-01   2 201740625 201740644 20 - 0.228 0.000 -13.490
ENSG00000003393 E081 2.6144824 0.0085480242 7.756831e-01 8.821774e-01 2 201740645 201741183 539 - 0.519 0.569 0.233
ENSG00000003393 E082 2.4689445 0.2263074965 3.461344e-01 5.836950e-01 2 201741184 201741570 387 - 0.425 0.631 0.976
ENSG00000003393 E083 4.3312546 0.0059553622 6.306851e-01 7.908382e-01 2 201741571 201741673 103 - 0.731 0.664 -0.279
ENSG00000003393 E084 41.2888360 0.0008601324 5.185735e-02 1.841069e-01 2 201741674 201741854 181 - 1.640 1.531 -0.373
ENSG00000003393 E085 35.2509825 0.0011976495 6.560192e-05 1.050416e-03 2 201744258 201744429 172 - 1.609 1.347 -0.903
ENSG00000003393 E086 19.7491866 0.0034793178 1.636117e-03 1.457155e-02 2 201746566 201746627 62 - 1.369 1.089 -0.988
ENSG00000003393 E087 37.2523840 0.0019358226 1.523929e-02 7.898616e-02 2 201746628 201746748 121 - 1.602 1.449 -0.522
ENSG00000003393 E088 1.3026600 0.0143451066 5.817804e-01   2 201747495 201749711 2217 - 0.378 0.279 -0.619
ENSG00000003393 E089 28.3577943 0.0020831623 8.208538e-02 2.489061e-01 2 201749712 201749789 78 - 1.478 1.356 -0.420
ENSG00000003393 E090 0.1723744 0.0346486894 2.533886e-01   2 201749790 201750755 966 - 0.000 0.162 13.105
ENSG00000003393 E091 30.3903346 0.0091891028 1.349464e-02 7.235959e-02 2 201753146 201753242 97 - 1.534 1.330 -0.704
ENSG00000003393 E092 0.3337900 0.0288806346 6.271667e-01   2 201754129 201754502 374 - 0.090 0.162 0.969
ENSG00000003393 E093 27.3700046 0.0164422707 7.075948e-01 8.402994e-01 2 201754503 201754623 121 - 1.444 1.407 -0.130
ENSG00000003393 E094 16.5477788 0.0643138690 9.293759e-01 9.667257e-01 2 201754624 201754671 48 - 1.238 1.202 -0.130
ENSG00000003393 E095 1.5940864 0.0137765289 3.378847e-01 5.761682e-01 2 201754672 201756827 2156 - 0.454 0.280 -1.029
ENSG00000003393 E096 0.7145081 0.0193874923 5.168514e-01   2 201756828 201756929 102 - 0.165 0.280 0.970
ENSG00000003393 E097 0.8631121 0.1698758680 2.752931e-01   2 201756930 201757401 472 - 0.163 0.378 1.608
ENSG00000003393 E098 36.0461134 0.5212423727 4.540301e-01 6.687622e-01 2 201757402 201757702 301 - 1.513 1.607 0.322
ENSG00000003393 E099 15.4383018 0.5171271527 5.603255e-01 7.435702e-01 2 201757703 201757759 57 - 1.174 1.236 0.221
ENSG00000003393 E100 0.0000000       2 201759457 201759480 24 -      
ENSG00000003393 E101 0.7673035 0.0193874923 8.489357e-02   2 201759481 201759488 8 - 0.333 0.000 -14.170
ENSG00000003393 E102 1.1599079 0.0816927032 8.843304e-01   2 201759489 201759497 9 - 0.332 0.368 0.215
ENSG00000003393 E103 1.4936980 0.0122722562 7.031848e-01 8.376438e-01 2 201759498 201759530 33 - 0.377 0.447 0.381
ENSG00000003393 E104 1.4936980 0.0122722562 7.031848e-01 8.376438e-01 2 201759531 201759538 8 - 0.377 0.447 0.381
ENSG00000003393 E105 31.3326844 0.0024972249 9.668307e-02 2.759358e-01 2 201759539 201760307 769 - 1.450 1.564 0.391
ENSG00000003393 E106 28.5209889 0.0015255510 6.396715e-01 7.967179e-01 2 201760308 201760880 573 - 1.454 1.427 -0.093
ENSG00000003393 E107 92.6905821 0.0020464763 1.025639e-01 2.863483e-01 2 201760881 201761324 444 - 1.972 1.906 -0.222
ENSG00000003393 E108 34.2147888 0.0017788326 4.101925e-01 6.361269e-01 2 201761325 201761402 78 - 1.543 1.495 -0.164
ENSG00000003393 E109 18.8198258 0.0052228627 2.571199e-01 4.958919e-01 2 201761403 201761411 9 - 1.308 1.213 -0.334
ENSG00000003393 E110 75.1158505 0.0005096492 7.281398e-02 2.304329e-01 2 201761412 201761674 263 - 1.883 1.810 -0.245
ENSG00000003393 E111 54.6051038 0.0022801127 3.104716e-01 5.509772e-01 2 201761675 201761818 144 - 1.742 1.692 -0.166
ENSG00000003393 E112 0.8377416 0.4097922563 4.666647e-01   2 201765383 201765603 221 - 0.165 0.377 1.585
ENSG00000003393 E113 1.8030273 0.0115957479 1.732203e-01 3.947870e-01 2 201765653 201765790 138 - 0.333 0.569 1.231
ENSG00000003393 E114 1.1190667 0.0153787590 6.340626e-01   2 201765791 201765827 37 - 0.284 0.372 0.553
ENSG00000003393 E115 52.0661741 0.0010274259 3.332711e-02 1.369660e-01 2 201767229 201767383 155 - 1.737 1.628 -0.367
ENSG00000003393 E116 33.3758395 0.0011099870 8.865653e-03 5.321805e-02 2 201768866 201768945 80 - 1.565 1.396 -0.580
ENSG00000003393 E117 0.4986023 0.0584348114 2.495696e-01   2 201768946 201769162 217 - 0.229 0.000 -13.479
ENSG00000003393 E118 0.6597577 0.6218495365 3.251837e-01   2 201769489 201769828 340 - 0.089 0.379 2.622
ENSG00000003393 E119 0.8100271 0.0167157787 2.423248e-01   2 201771956 201772009 54 - 0.165 0.372 1.555
ENSG00000003393 E120 0.2922838 0.0262701801 6.297252e-01   2 201778441 201778487 47 - 0.090 0.162 0.966
ENSG00000003393 E121 1.4568735 0.0128219538 4.424575e-01 6.603607e-01 2 201779979 201780083 105 - 0.417 0.279 -0.839
ENSG00000003393 E122 3.2828863 0.0141609721 3.929536e-01 6.227666e-01 2 201780084 201780876 793 - 0.650 0.513 -0.618
ENSG00000003393 E123 18.8628882 0.0018857954 8.727052e-01 9.374156e-01 2 201780877 201781079 203 - 1.278 1.270 -0.031
ENSG00000003393 E124 2.2798845 0.0092446427 2.303808e-01 4.655351e-01 2 201781080 201781158 79 - 0.417 0.619 0.969
ENSG00000003393 E125 2.5727313 0.1261618619 8.521056e-01 9.262501e-01 2 201781885 201782112 228 - 0.549 0.514 -0.164