ENSG00000001617

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000002829 ENSG00000001617 HEK293_OSMI2_6hA HEK293_TMG_6hB SEMA3F protein_coding protein_coding 7.157893 9.766197 5.911822 0.5194494 0.23262 -0.7232321 2.2259612 3.2359338 1.5111387 0.34714702 0.06642065 -1.0934819 0.3111000 0.33246667 0.25553333 -0.07693333 0.59214893 0.02852875 FALSE  
ENST00000413852 ENSG00000001617 HEK293_OSMI2_6hA HEK293_TMG_6hB SEMA3F protein_coding protein_coding 7.157893 9.766197 5.911822 0.5194494 0.23262 -0.7232321 2.7466649 4.3409089 2.1800314 0.53180391 0.10323559 -0.9903653 0.3653542 0.44103333 0.36896667 -0.07206667 0.67562493 0.02852875 FALSE  
ENST00000414301 ENSG00000001617 HEK293_OSMI2_6hA HEK293_TMG_6hB SEMA3F protein_coding protein_coding 7.157893 9.766197 5.911822 0.5194494 0.23262 -0.7232321 0.6934731 0.8590422 1.5647295 0.33498580 0.13079293 0.8576059 0.1042875 0.08813333 0.26423333 0.17610000 0.15572624 0.02852875 FALSE  
MSTRG.22986.2 ENSG00000001617 HEK293_OSMI2_6hA HEK293_TMG_6hB SEMA3F protein_coding   7.157893 9.766197 5.911822 0.5194494 0.23262 -0.7232321 1.1024003 0.9928826 0.1732735 0.07360493 0.05841111 -2.4520827 0.1613625 0.10256667 0.02873333 -0.07383333 0.02852875 0.02852875 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000001617 E001 0.4756169 0.0273852793 3.311281e-01   3 50155045 50155058 14 + 0.000 0.210 10.639
ENSG00000001617 E002 1.2258340 0.0725363436 6.432806e-02   3 50155059 50155090 32 + 0.000 0.392 13.648
ENSG00000001617 E003 4.9459856 0.0057182206 1.144569e-01 0.3065547240 3 50155091 50155147 57 + 0.546 0.791 1.042
ENSG00000001617 E004 4.8022534 0.0053021451 1.158824e-01 0.3089407934 3 50155148 50155323 176 + 0.546 0.790 1.040
ENSG00000001617 E005 0.7677130 0.0179288862 1.307295e-01   3 50155324 50155410 87 + 0.000 0.308 13.537
ENSG00000001617 E006 9.1966348 0.0201482529 5.270145e-01 0.7198577241 3 50155411 50155564 154 + 0.906 0.988 0.309
ENSG00000001617 E007 0.1426347 0.0313022045 1.996595e-01   3 50155565 50155843 279 + 0.177 0.000 -13.506
ENSG00000001617 E008 0.0000000       3 50159019 50159288 270 +      
ENSG00000001617 E009 9.6058074 0.0041901171 3.552668e-01 0.5919533365 3 50159575 50159582 8 + 0.906 1.013 0.402
ENSG00000001617 E010 30.3798888 0.0020886793 8.384022e-01 0.9185568045 3 50159583 50159691 109 + 1.465 1.449 -0.057
ENSG00000001617 E011 29.9206908 0.0015034517 1.131397e-01 0.3044021541 3 50159692 50159734 43 + 1.521 1.412 -0.376
ENSG00000001617 E012 24.0726672 0.0013896002 3.193573e-02 0.1330220316 3 50173793 50173806 14 + 1.465 1.306 -0.551
ENSG00000001617 E013 62.6446020 0.0052859950 1.268724e-02 0.0691991401 3 50173807 50173953 147 + 1.854 1.711 -0.485
ENSG00000001617 E014 0.0000000       3 50173954 50173956 3 +      
ENSG00000001617 E015 48.1474754 0.0076466537 7.996019e-02 0.2447430747 3 50174052 50174114 63 + 1.727 1.607 -0.407
ENSG00000001617 E016 1.0952262 0.1218378755 3.466307e-01   3 50174213 50174230 18 + 0.402 0.213 -1.267
ENSG00000001617 E017 53.4535809 0.0035963297 5.849584e-01 0.7603005910 3 50174231 50174350 120 + 1.714 1.680 -0.117
ENSG00000001617 E018 16.1936225 0.0023556287 4.129922e-01 0.6383621213 3 50175096 50175188 93 + 1.148 1.223 0.264
ENSG00000001617 E019 49.8981698 0.0057604429 3.190171e-01 0.5587333483 3 50176768 50176861 94 + 1.713 1.648 -0.220
ENSG00000001617 E020 54.2577379 0.0007596402 1.061637e-01 0.2926365468 3 50182284 50182403 120 + 1.762 1.679 -0.283
ENSG00000001617 E021 1.7614484 0.3036017934 9.628394e-01 0.9833914094 3 50182638 50182643 6 + 0.398 0.424 0.143
ENSG00000001617 E022 49.6776313 0.0007351003 4.330588e-01 0.6535204592 3 50182644 50182783 140 + 1.697 1.654 -0.148
ENSG00000001617 E023 44.4435438 0.0010583674 7.772735e-01 0.8831012583 3 50182904 50183018 115 + 1.626 1.608 -0.063
ENSG00000001617 E024 47.8890227 0.0022375551 6.929297e-01 0.8310054341 3 50183186 50183255 70 + 1.661 1.634 -0.090
ENSG00000001617 E025 62.5638661 0.0006186459 1.447831e-01 0.3546364535 3 50183420 50183564 145 + 1.812 1.742 -0.238
ENSG00000001617 E026 0.0000000       3 50183565 50183608 44 +      
ENSG00000001617 E027 1.3493278 0.0274026418 6.320020e-01   3 50184272 50184591 320 + 0.400 0.309 -0.543
ENSG00000001617 E028 86.2087221 0.0005649014 7.433839e-01 0.8626148623 3 50184592 50184814 223 + 1.895 1.906 0.038
ENSG00000001617 E029 61.8299740 0.0017745877 5.653457e-01 0.7469344167 3 50185443 50185531 89 + 1.743 1.770 0.093
ENSG00000001617 E030 47.8040493 0.0081668068 7.359828e-01 0.8579309093 3 50185666 50185707 42 + 1.669 1.647 -0.076
ENSG00000001617 E031 64.0896455 0.0008817098 5.063993e-02 0.1811873051 3 50185889 50186046 158 + 1.706 1.801 0.320
ENSG00000001617 E032 40.9648339 0.0008783409 2.546267e-01 0.4931336675 3 50186281 50186348 68 + 1.534 1.601 0.227
ENSG00000001617 E033 53.3288913 0.0014689952 8.511784e-01 0.9256925193 3 50186613 50186746 134 + 1.688 1.695 0.024
ENSG00000001617 E034 225.1574289 0.0003185032 7.493308e-06 0.0001632503 3 50187705 50189098 1394 + 2.234 2.344 0.366