ENSG00000289372

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000688528 ENSG00000289372 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.630973 5.048079 3.614524 0.2710786 0.3709571 -0.4807979 0.57487016 0.75643449 0.4036034 0.07829748 0.05631569 -0.8899143 0.15389583 0.152500000 0.11683333 -0.035666667 0.69526559 0.02018622    
MSTRG.28863.1 ENSG00000289372 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   3.630973 5.048079 3.614524 0.2710786 0.3709571 -0.4807979 1.16258158 1.37713542 1.2023664 0.28179642 0.30413834 -0.1942829 0.33927083 0.269700000 0.32980000 0.060100000 0.81440224 0.02018622    
MSTRG.28863.2 ENSG00000289372 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   3.630973 5.048079 3.614524 0.2710786 0.3709571 -0.4807979 0.07677998 0.01916804 0.2337689 0.01916804 0.08908966 3.0630538 0.02140417 0.003633333 0.06870000 0.065066667 0.02018622 0.02018622    
MSTRG.28863.4 ENSG00000289372 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   3.630973 5.048079 3.614524 0.2710786 0.3709571 -0.4807979 1.33413710 2.08528683 1.5059587 0.14260827 0.16011528 -0.4669173 0.35879583 0.415533333 0.41670000 0.001166667 1.00000000 0.02018622    
MSTRG.28863.5 ENSG00000289372 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   3.630973 5.048079 3.614524 0.2710786 0.3709571 -0.4807979 0.44603589 0.81005405 0.2688268 0.13155558 0.19416639 -1.5563495 0.11223750 0.158666667 0.06796667 -0.090700000 0.38545453 0.02018622    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000289372 E001 14.8181246 0.0032878188 3.157137e-01 0.4584835498 6 117608869 117609146 278 - 1.126 1.215 0.318
ENSG00000289372 E002 0.5890081 0.0204967516 6.430161e-01 0.7556493404 6 117631965 117631968 4 - 0.261 0.180 -0.682
ENSG00000289372 E003 0.8888167 0.0202527757 5.669140e-01 0.6937949581 6 117631969 117632003 35 - 0.349 0.248 -0.684
ENSG00000289372 E004 15.2090142 0.0013234911 5.840115e-02 0.1238905612 6 117658976 117659082 107 - 1.068 1.236 0.598
ENSG00000289372 E005 23.6499571 0.0008731489 6.095476e-05 0.0003361677 6 117659083 117659233 151 - 1.152 1.451 1.049
ENSG00000289372 E006 5.2014496 0.0046485683 5.531264e-01 0.6823210768 6 117659234 117659236 3 - 0.709 0.789 0.323
ENSG00000289372 E007 37.3953419 0.0016920697 8.109001e-02 0.1612547873 6 117662906 117663066 161 - 1.503 1.599 0.328
ENSG00000289372 E008 37.4036235 0.0006977461 7.619590e-02 0.1534268727 6 117664630 117664813 184 - 1.625 1.530 -0.323
ENSG00000289372 E009 22.6175786 0.0010112702 5.350001e-04 0.0022908002 6 117664814 117664862 49 - 1.492 1.255 -0.824
ENSG00000289372 E010 0.8964071 0.2641206501 9.939084e-03 0.0286089949 6 117667293 117667360 68 - 0.541 0.000 -12.149
ENSG00000289372 E011 10.1290034 0.0325461835 1.198728e-01 0.2197980583 6 117673747 117674082 336 - 0.880 1.082 0.750
ENSG00000289372 E012 32.7632942 0.0013103651 4.888316e-03 0.0156191813 6 117675097 117675445 349 - 1.603 1.439 -0.561