ENSG00000288061

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000660892 ENSG00000288061 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.935458 7.312218 1.626509 0.6467804 0.6569138 -2.161659 0.2434793 0.2768355 0.2367133 0.05278783 0.04808983 -0.2173879 0.08319583 0.03793333 0.1947333 0.15680000 0.04945665 0.04945665   FALSE
ENST00000686873 ENSG00000288061 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.935458 7.312218 1.626509 0.6467804 0.6569138 -2.161659 0.8924110 1.6397917 0.0000000 0.87046460 0.00000000 -7.3661401 0.22552500 0.23860000 0.0000000 -0.23860000 0.33907139 0.04945665 FALSE FALSE
ENST00000690118 ENSG00000288061 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.935458 7.312218 1.626509 0.6467804 0.6569138 -2.161659 0.7482284 1.5551794 0.3931705 1.55517936 0.14250048 -1.9568661 0.20300833 0.18650000 0.3084333 0.12193333 0.30571997 0.04945665 FALSE FALSE
ENST00000690490 ENSG00000288061 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.935458 7.312218 1.626509 0.6467804 0.6569138 -2.161659 0.3014445 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.10054583 0.00000000 0.0000000 0.00000000   0.04945665 FALSE FALSE
MSTRG.6487.1 ENSG00000288061 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   3.935458 7.312218 1.626509 0.6467804 0.6569138 -2.161659 1.7498945 3.8404111 0.9966255 0.29642645 0.59339121 -1.9354855 0.38773750 0.53696667 0.4968333 -0.04013333 1.00000000 0.04945665   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000288061 E001 0.1482932 0.043630995 8.727965e-01   11 123062607 123062607 1 + 0.001 0.053 6.408
ENSG00000288061 E002 0.5911836 0.022260819 1.000000e+00 1.000000000 11 123062608 123062624 17 + 0.000 0.143 9.313
ENSG00000288061 E003 0.5911836 0.022260819 1.000000e+00 1.000000000 11 123062625 123062626 2 + 0.000 0.143 9.313
ENSG00000288061 E004 2.9127816 0.005791319 2.888441e-01 0.429481415 11 123062627 123062650 24 + 0.259 0.487 1.343
ENSG00000288061 E005 3.6908810 0.009153402 4.943621e-01 0.631307909 11 123062651 123062654 4 + 0.421 0.554 0.662
ENSG00000288061 E006 15.4144311 0.001614962 2.367754e-01 0.370456791 11 123062655 123062697 43 + 0.922 1.056 0.495
ENSG00000288061 E007 22.2672447 0.001228467 9.835169e-02 0.188014574 11 123062698 123063038 341 + 1.033 1.191 0.568
ENSG00000288061 E008 18.7107551 0.001840887 8.955234e-01 0.937253215 11 123063039 123063231 193 + 1.122 1.103 -0.069
ENSG00000288061 E009 3.7234384 0.004839576 2.702856e-02 0.066055352 11 123063331 123063513 183 + 0.827 0.469 -1.556
ENSG00000288061 E010 2.8494006 0.007475308 2.369444e-05 0.000144489 11 123084373 123084877 505 + 0.962 0.309 -2.979