ENSG00000286833

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000657012 ENSG00000286833 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 1.926674 3.183056 0.6421332 0.1987719 0.1063155 -2.291699 0.02049674 0.00000000 0.07860259 0.00000000 0.0425980 3.1473489 0.02861667 0.00000000 0.12150000 0.1215000 0.02913636 0.02913636 FALSE TRUE
ENST00000666693 ENSG00000286833 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 1.926674 3.183056 0.6421332 0.1987719 0.1063155 -2.291699 0.04082531 0.04790185 0.03292400 0.03741917 0.0329240 -0.4318248 0.07849583 0.01673333 0.06453333 0.0478000 0.83843369 0.02913636 FALSE TRUE
ENST00000684800 ENSG00000286833 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 1.926674 3.183056 0.6421332 0.1987719 0.1063155 -2.291699 1.34224705 2.24652783 0.27625278 1.12357303 0.1381371 -2.9787430 0.65580000 0.66446667 0.51560000 -0.1488667 0.61419624 0.02913636   FALSE
ENST00000686804 ENSG00000286833 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 1.926674 3.183056 0.6421332 0.1987719 0.1063155 -2.291699 0.16130216 0.00000000 0.00000000 0.00000000 0.0000000 0.0000000 0.07694583 0.00000000 0.00000000 0.0000000   0.02913636   FALSE
ENST00000688373 ENSG00000286833 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 1.926674 3.183056 0.6421332 0.1987719 0.1063155 -2.291699 0.33000827 0.88862590 0.00000000 0.88862590 0.0000000 -6.4896487 0.12284583 0.31880000 0.00000000 -0.3188000 1.00000000 0.02913636   FALSE
ENST00000690190 ENSG00000286833 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 1.926674 3.183056 0.6421332 0.1987719 0.1063155 -2.291699 0.03179423 0.00000000 0.25435380 0.00000000 0.2543538 4.7243982 0.03729583 0.00000000 0.29836667 0.2983667 0.63526878 0.02913636   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000286833 E001 0.000000       2 132347468 132347472 5 +      
ENSG00000286833 E002 0.000000       2 132347473 132347480 8 +      
ENSG00000286833 E003 0.147249 0.050748219 2.263537e-01   2 132347481 132347490 10 + 0.202 0.000 -11.785
ENSG00000286833 E004 0.147249 0.050748219 2.263537e-01   2 132347491 132347492 2 + 0.202 0.000 -12.939
ENSG00000286833 E005 0.147249 0.050748219 2.263537e-01   2 132347493 132347494 2 + 0.202 0.000 -12.939
ENSG00000286833 E006 0.147249 0.050748219 2.263537e-01   2 132347495 132347502 8 + 0.202 0.000 -12.939
ENSG00000286833 E007 0.147249 0.050748219 2.263537e-01   2 132347503 132347515 13 + 0.202 0.000 -12.939
ENSG00000286833 E008 5.455927 0.004649123 3.351215e-06 2.483289e-05 2 132347516 132347865 350 + 0.528 0.778 1.073
ENSG00000286833 E009 0.147249 0.050748219 2.263537e-01   2 132357640 132357802 163 + 0.202 0.000 -12.939
ENSG00000286833 E010 1.072699 0.018201233 2.531576e-02 6.252438e-02 2 132363805 132365130 1326 + 0.598 0.133 -3.055