ENSG00000286619

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000652821 ENSG00000286619 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.416753 1.922984 1.704083 0.08431622 0.08831345 -0.1733929 0.19267339 0.0000000 0.06052766 0.00000000 0.060527657 2.81818912 0.05980000 0.00000000 0.03800000 0.038000000 0.778771875 0.003525454   FALSE
ENST00000653906 ENSG00000286619 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.416753 1.922984 1.704083 0.08431622 0.08831345 -0.1733929 0.58946113 0.3536455 0.17449995 0.07479774 0.028486761 -0.97891218 0.19027500 0.18603333 0.10460000 -0.081433333 0.429950268 0.003525454 TRUE TRUE
ENST00000656162 ENSG00000286619 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.416753 1.922984 1.704083 0.08431622 0.08831345 -0.1733929 0.17723143 0.0000000 0.22831234 0.00000000 0.084102644 4.57478177 0.09313333 0.00000000 0.13950000 0.139500000 0.003525454 0.003525454 TRUE FALSE
ENST00000656452 ENSG00000286619 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.416753 1.922984 1.704083 0.08431622 0.08831345 -0.1733929 0.11299986 0.0908409 0.13883686 0.05792489 0.009061378 0.56165104 0.05117500 0.05016667 0.08170000 0.031533333 0.515260774 0.003525454 FALSE TRUE
ENST00000656763 ENSG00000286619 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.416753 1.922984 1.704083 0.08431622 0.08831345 -0.1733929 0.78274547 0.5768869 0.66530914 0.29259028 0.332902036 0.20246562 0.35135000 0.28733333 0.38040000 0.093066667 0.950762766 0.003525454 TRUE FALSE
ENST00000659861 ENSG00000286619 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.416753 1.922984 1.704083 0.08431622 0.08831345 -0.1733929 0.11478314 0.1962320 0.18762551 0.10995654 0.187625511 -0.06149897 0.05272917 0.10383333 0.09986667 -0.003966667 0.757610345 0.003525454   FALSE
ENST00000662563 ENSG00000286619 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.416753 1.922984 1.704083 0.08431622 0.08831345 -0.1733929 0.02970008 0.1744080 0.00000000 0.17440803 0.000000000 -4.20482955 0.01715417 0.09913333 0.00000000 -0.099133333 0.810330771 0.003525454 TRUE FALSE
ENST00000662659 ENSG00000286619 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.416753 1.922984 1.704083 0.08431622 0.08831345 -0.1733929 0.07071926 0.4263117 0.00000000 0.24238833 0.000000000 -5.44728719 0.03598750 0.22043333 0.00000000 -0.220433333 0.154990619 0.003525454   FALSE
ENST00000664917 ENSG00000286619 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.416753 1.922984 1.704083 0.08431622 0.08831345 -0.1733929 0.03746317 0.0000000 0.08105495 0.00000000 0.081054948 3.18673742 0.01707500 0.00000000 0.05086667 0.050866667 0.787463305 0.003525454 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000286619 E001 0.0000000       1 205813322 205813328 7 +      
ENSG00000286619 E002 0.0000000       1 205813329 205813336 8 +      
ENSG00000286619 E003 0.0000000       1 205813337 205813344 8 +      
ENSG00000286619 E004 0.0000000       1 205813345 205813346 2 +      
ENSG00000286619 E005 0.0000000       1 205813347 205813347 1 +      
ENSG00000286619 E006 0.0000000       1 205813348 205813352 5 +      
ENSG00000286619 E007 0.5922303 0.018102962 0.22533869 0.35681530 1 205813353 205813361 9 + 0.315 0.113 -1.844
ENSG00000286619 E008 2.0616346 0.007502777 0.92451219 0.95644467 1 205813362 205813408 47 + 0.496 0.489 -0.037
ENSG00000286619 E009 4.9234160 0.005027323 0.35765366 0.50207416 1 205813409 205813535 127 + 0.826 0.713 -0.449
ENSG00000286619 E010 4.9441417 0.172033126 0.74046676 0.82988886 1 205813536 205813585 50 + 0.823 0.720 -0.415
ENSG00000286619 E011 0.2934659 0.028399717 0.87963477   1 205836239 205836303 65 + 0.132 0.113 -0.260
ENSG00000286619 E012 1.6834757 0.175970521 0.78493586 0.86210567 1 205853788 205853874 87 + 0.384 0.447 0.341
ENSG00000286619 E013 0.0000000       1 205857100 205857498 399 +      
ENSG00000286619 E014 0.1482932 0.041377053 0.58393019   1 205857499 205857579 81 + 0.000 0.113 10.107
ENSG00000286619 E015 2.2519589 0.008438302 0.93106586 0.96058093 1 205858143 205858211 69 + 0.496 0.490 -0.033
ENSG00000286619 E016 2.0357992 0.008710516 0.35563091 0.50000527 1 205858212 205858289 78 + 0.543 0.396 -0.741
ENSG00000286619 E017 0.5138669 0.020414466 0.45460075 0.59522592 1 205858290 205858293 4 + 0.233 0.113 -1.255
ENSG00000286619 E018 0.7353121 0.018679502 0.84005423 0.90011512 1 205858294 205858320 27 + 0.233 0.203 -0.254
ENSG00000286619 E019 1.5718174 0.232206412 0.21986605 0.35025447 1 205858321 205859826 1506 + 0.542 0.279 -1.466
ENSG00000286619 E020 1.0298222 0.033446904 0.57662549 0.70201124 1 205862445 205862598 154 + 0.233 0.341 0.744
ENSG00000286619 E021 0.2924217 0.029078516 0.15088043   1 205864133 205864257 125 + 0.233 0.000 -12.403
ENSG00000286619 E022 0.3289534 0.028933890 0.88247036   1 205868770 205868833 64 + 0.132 0.113 -0.257
ENSG00000286619 E023 0.1472490 0.043458116 0.40462019   1 205882421 205882514 94 + 0.132 0.000 -11.486
ENSG00000286619 E024 0.0000000       1 205882515 205882549 35 +      
ENSG00000286619 E025 7.3580323 0.002410563 0.17727946 0.29769505 1 205890047 205891155 1109 + 0.802 0.970 0.644
ENSG00000286619 E026 10.3527881 0.001800916 0.01758161 0.04622684 1 205891156 205891309 154 + 1.162 0.942 -0.805
ENSG00000286619 E027 19.0425675 0.026055563 0.61869862 0.73625529 1 205894168 205894466 299 + 1.314 1.272 -0.147
ENSG00000286619 E028 79.1127804 0.009132097 0.02886892 0.06973974 1 205894467 205896082 1616 + 1.843 1.930 0.291