ENSG00000285967

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000647750 ENSG00000285967 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPBL-DT lncRNA lncRNA 3.229226 3.315931 3.626361 0.2474482 0.2939122 0.1287371 0.28334401 0.2359589 0.3974539 0.03442408 0.009326383 0.7282198 0.08738333 0.07216667 0.11056667 0.0384000 0.379647701 0.001868746 TRUE FALSE
ENST00000647824 ENSG00000285967 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPBL-DT lncRNA lncRNA 3.229226 3.315931 3.626361 0.2474482 0.2939122 0.1287371 0.42633841 0.2604811 0.1137244 0.26048113 0.113724409 -1.1283978 0.16561667 0.08253333 0.03393333 -0.0486000 0.999554431 0.001868746 TRUE FALSE
ENST00000649921 ENSG00000285967 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPBL-DT lncRNA lncRNA 3.229226 3.315931 3.626361 0.2474482 0.2939122 0.1287371 1.75662059 0.8995050 2.3444209 0.18355714 0.055438738 1.3722188 0.52943750 0.27300000 0.65450000 0.3815000 0.001868746 0.001868746 FALSE FALSE
MSTRG.26080.3 ENSG00000285967 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPBL-DT lncRNA   3.229226 3.315931 3.626361 0.2474482 0.2939122 0.1287371 0.05902081 0.0000000 0.2873584 0.00000000 0.147000293 4.8941311 0.01936667 0.00000000 0.08630000 0.0863000 0.220448938 0.001868746 TRUE FALSE
MSTRG.26080.6 ENSG00000285967 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPBL-DT lncRNA   3.229226 3.315931 3.626361 0.2474482 0.2939122 0.1287371 0.70390176 1.9199862 0.4834035 0.32017822 0.483403478 -1.9677508 0.19818750 0.57230000 0.11473333 -0.4575667 0.067888179 0.001868746 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000285967 E001 10.840646 0.0017030132 9.610130e-01 9.794599e-01 5 36864425 36865843 1419 - 1.066 1.068 0.009
ENSG00000285967 E002 2.031547 0.0069453227 6.356585e-01 7.498823e-01 5 36865844 36866026 183 - 0.509 0.433 -0.378
ENSG00000285967 E003 38.844097 0.0015641101 1.148385e-01 2.125966e-01 5 36871364 36871918 555 - 1.558 1.653 0.326
ENSG00000285967 E004 36.027583 0.0061167304 9.580302e-01 9.776928e-01 5 36871919 36872642 724 - 1.563 1.571 0.025
ENSG00000285967 E005 108.553028 0.0005415489 5.238376e-14 1.550617e-12 5 36872643 36875670 3028 - 2.110 1.890 -0.739
ENSG00000285967 E006 14.954063 0.0012576791 9.187163e-01 9.526505e-01 5 36875671 36875791 121 - 1.193 1.192 -0.003
ENSG00000285967 E007 11.456898 0.0025920500 9.442639e-01 9.690677e-01 5 36875792 36875843 52 - 1.084 1.084 0.001
ENSG00000285967 E008 37.058679 0.0012168033 1.383211e-03 5.251619e-03 5 36875844 36876158 315 - 1.490 1.674 0.627
ENSG00000285967 E009 59.168738 0.0052130387 6.883604e-06 4.748664e-05 5 36876159 36876700 542 - 1.663 1.892 0.775