ENSG00000284719

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000641382 ENSG00000284719 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.517959 0.8791923 0.2468273 0.05551182 0.05982506 -1.791697 0.11800674 0.20086705 0.07013851 0.06759074 0.004727773 -1.3957661 0.25621667 0.23643333 0.3135000 0.07706667 0.87905453 0.04459118   FALSE
ENST00000641632 ENSG00000284719 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.517959 0.8791923 0.2468273 0.05551182 0.05982506 -1.791697 0.05780314 0.07862144 0.00000000 0.04510370 0.000000000 -3.1476558 0.09227083 0.09153333 0.0000000 -0.09153333 0.64243545 0.04459118   FALSE
ENST00000685822 ENSG00000284719 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.517959 0.8791923 0.2468273 0.05551182 0.05982506 -1.791697 0.04133200 0.06595334 0.00000000 0.06595334 0.000000000 -2.9251134 0.09947500 0.07230000 0.0000000 -0.07230000 1.00000000 0.04459118   FALSE
ENST00000687094 ENSG00000284719 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.517959 0.8791923 0.2468273 0.05551182 0.05982506 -1.791697 0.23140223 0.48925794 0.10389674 0.11717379 0.030772935 -2.1320588 0.37771250 0.54810000 0.4087333 -0.13936667 0.65798937 0.04459118   FALSE
ENST00000689515 ENSG00000284719 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.517959 0.8791923 0.2468273 0.05551182 0.05982506 -1.791697 0.05758647 0.04449257 0.07279201 0.02637448 0.029349174 0.6034319 0.15695000 0.05160000 0.2777667 0.22616667 0.04459118 0.04459118   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000284719 E001 0.0000000       1 39799419 39799421 3 +      
ENSG00000284719 E002 0.0000000       1 39799422 39799432 11 +      
ENSG00000284719 E003 0.1817044 0.044464746 1.000000000   1 39799433 39799443 11 + 0.000 0.079 9.114
ENSG00000284719 E004 2.5506362 0.006632597 0.011641903 0.03268023 1 39799444 39799581 138 + 0.721 0.413 -1.420
ENSG00000284719 E005 1.3285997 0.010926145 0.087355354 0.17112447 1 39799582 39800325 744 + 0.495 0.254 -1.418
ENSG00000284719 E006 0.8481309 0.015221288 0.388571436 0.53264902 1 39800326 39800391 66 + 0.315 0.203 -0.833
ENSG00000284719 E007 0.0000000       1 39800392 39800516 125 +      
ENSG00000284719 E008 0.9545924 0.014915458 0.220596314 0.35113437 1 39804521 39804877 357 + 0.000 0.300 12.133
ENSG00000284719 E009 2.5776003 0.006397145 0.327995890 0.47145194 1 39804878 39804921 44 + 0.315 0.555 1.281
ENSG00000284719 E010 4.0170046 0.005845014 0.157608237 0.27193202 1 39804922 39805032 111 + 0.721 0.601 -0.510
ENSG00000284719 E011 1.8369777 0.010082087 0.221220562 0.35189739 1 39805033 39805452 420 + 0.185 0.475 1.901
ENSG00000284719 E012 5.0205248 0.005277487 0.352263457 0.49653261 1 39808002 39808198 197 + 0.564 0.776 0.900
ENSG00000284719 E013 3.1332819 0.010463853 0.004127436 0.01349862 1 39809062 39809450 389 + 0.000 0.642 13.837