ENSG00000283050

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000651444 ENSG00000283050 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IP12 transcribed_unprocessed_pseudogene processed_transcript 7.047861 5.631974 6.742632 0.8035673 0.4505487 0.25925 3.54257282 3.93616677 2.5624230 0.58904786 0.16132095 -0.6173240 0.497612500 0.69900000 0.38076667 -0.31823333 9.616959e-10 9.616959e-10 FALSE TRUE
ENST00000652280 ENSG00000283050 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IP12 transcribed_unprocessed_pseudogene retained_intron 7.047861 5.631974 6.742632 0.8035673 0.4505487 0.25925 0.82095898 0.37640955 0.7236827 0.07230507 0.09495292 0.9250255 0.113108333 0.06570000 0.10653333 0.04083333 1.986314e-01 9.616959e-10 FALSE FALSE
ENST00000686466 ENSG00000283050 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IP12 transcribed_unprocessed_pseudogene processed_transcript 7.047861 5.631974 6.742632 0.8035673 0.4505487 0.25925 0.18269206 0.00000000 0.3632626 0.00000000 0.08905865 5.2221191 0.026925000 0.00000000 0.05270000 0.05270000 2.869632e-05 9.616959e-10   FALSE
ENST00000692028 ENSG00000283050 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IP12 transcribed_unprocessed_pseudogene processed_transcript 7.047861 5.631974 6.742632 0.8035673 0.4505487 0.25925 0.05258764 0.00000000 0.4207011 0.00000000 0.42070115 5.4286153 0.007020833 0.00000000 0.05616667 0.05616667 8.543836e-01 9.616959e-10   FALSE
MSTRG.25401.10 ENSG00000283050 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IP12 transcribed_unprocessed_pseudogene   7.047861 5.631974 6.742632 0.8035673 0.4505487 0.25925 0.35361753 0.07383758 0.4131222 0.07383758 0.12636669 2.3354054 0.049670833 0.01216667 0.06340000 0.05123333 2.065444e-01 9.616959e-10   FALSE
MSTRG.25401.13 ENSG00000283050 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IP12 transcribed_unprocessed_pseudogene   7.047861 5.631974 6.742632 0.8035673 0.4505487 0.25925 0.68772640 0.32589360 0.7495031 0.13533371 0.01996308 1.1770516 0.100104167 0.05336667 0.11206667 0.05870000 1.128586e-01 9.616959e-10   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000283050 E001 0.3686942 0.0285870642 9.246716e-01 9.565674e-01 4 119404232 119404681 450 - 0.120 0.125 0.061
ENSG00000283050 E002 1.0319116 0.0124632187 5.105559e-01 6.457475e-01 4 119404682 119405522 841 - 0.214 0.367 1.059
ENSG00000283050 E003 261.9391953 0.0079224690 1.041098e-17 5.100409e-16 4 119405523 119407966 2444 - 2.169 2.554 1.282
ENSG00000283050 E004 36.5053826 0.0027827608 5.194874e-01 6.535880e-01 4 119407967 119408602 636 - 1.504 1.616 0.380
ENSG00000283050 E005 90.3567930 0.0004746989 8.158156e-01 8.834343e-01 4 119408603 119409891 1289 - 1.914 1.980 0.222
ENSG00000283050 E006 10.6157844 0.0017738212 6.889383e-01 7.909324e-01 4 119409892 119410138 247 - 1.049 1.078 0.103
ENSG00000283050 E007 8.1391580 0.0339685502 7.722965e-01 8.530157e-01 4 119410232 119410289 58 - 0.953 0.980 0.101
ENSG00000283050 E008 5.8667248 0.0716098245 1.625152e-01 2.784212e-01 4 119410517 119410658 142 - 0.920 0.750 -0.663
ENSG00000283050 E009 1.6951053 0.0392346851 2.926223e-01 4.335918e-01 4 119410659 119410712 54 - 0.509 0.366 -0.754
ENSG00000283050 E010 0.0000000       4 119412281 119412351 71 -      
ENSG00000283050 E011 0.5514428 0.0196628981 1.051940e-01 1.983901e-01 4 119412352 119412366 15 - 0.000 0.300 12.059
ENSG00000283050 E012 0.7437457 0.0153787590 1.310023e-01 2.355363e-01 4 119412367 119412414 48 - 0.357 0.124 -1.943
ENSG00000283050 E013 3.9567430 0.0058702844 2.640917e-01 4.020360e-01 4 119412415 119412542 128 - 0.738 0.636 -0.426
ENSG00000283050 E014 1.2209923 0.0104287366 3.771351e-01 5.214736e-01 4 119413289 119413407 119 - 0.414 0.300 -0.680
ENSG00000283050 E015 0.0000000       4 119418940 119419041 102 -      
ENSG00000283050 E016 5.4014578 0.0460222872 2.420743e-01 3.766447e-01 4 119419042 119419106 65 - 0.849 0.732 -0.466
ENSG00000283050 E017 22.3598349 0.0626883927 4.588943e-01 5.991350e-01 4 119419959 119420155 197 - 1.351 1.364 0.048
ENSG00000283050 E018 22.6405278 0.0773987037 4.613500e-01 6.013208e-01 4 119420494 119420590 97 - 1.357 1.372 0.053
ENSG00000283050 E019 2.1003312 0.0089329443 6.152908e-01 7.335977e-01 4 119420591 119421337 747 - 0.510 0.476 -0.164
ENSG00000283050 E020 0.6255398 0.0274496762 3.796201e-01 5.238841e-01 4 119422207 119422256 50 - 0.120 0.300 1.639
ENSG00000283050 E021 0.7436440 0.3172655782 8.904751e-01 9.340396e-01 4 119422257 119422320 64 - 0.215 0.291 0.580
ENSG00000283050 E022 1.5833438 0.0085428502 4.064582e-01 5.501050e-01 4 119422321 119422404 84 - 0.464 0.367 -0.527
ENSG00000283050 E023 0.1817044 0.0390389198 5.488006e-01   4 119422405 119422450 46 - 0.000 0.125 10.489
ENSG00000283050 E024 6.7607211 0.0890620166 9.515440e-01 9.736759e-01 4 119422451 119422574 124 - 0.808 0.932 0.477
ENSG00000283050 E025 8.3598487 0.0020511442 2.468952e-01 3.822962e-01 4 119429420 119429609 190 - 0.997 0.937 -0.225
ENSG00000283050 E026 0.0000000       4 119430000 119430082 83 -      
ENSG00000283050 E027 11.4997096 0.0015488935 3.729399e-02 8.602711e-02 4 119431837 119431901 65 - 1.158 1.027 -0.476
ENSG00000283050 E028 29.6353513 0.0015589788 4.931220e-02 1.079407e-01 4 119434740 119434975 236 - 1.509 1.456 -0.180
ENSG00000283050 E029 9.5757329 0.0020035196 2.940409e-02 7.077917e-02 4 119440560 119440560 1 - 1.096 0.937 -0.587
ENSG00000283050 E030 14.4312329 0.0014335434 4.733966e-02 1.044350e-01 4 119440561 119440635 75 - 1.237 1.134 -0.366
ENSG00000283050 E031 23.5226712 0.0057543350 7.368469e-02 1.494288e-01 4 119440636 119440950 315 - 1.418 1.355 -0.220
ENSG00000283050 E032 8.7287872 0.0534614611 3.857167e-02 8.840280e-02 4 119440951 119441052 102 - 1.085 0.869 -0.805
ENSG00000283050 E033 6.5583862 0.0058675249 2.525760e-03 8.839624e-03 4 119441053 119441054 2 - 1.011 0.698 -1.213
ENSG00000283050 E034 8.1221488 0.0259786036 9.482223e-03 2.749363e-02 4 119442158 119442217 60 - 1.074 0.804 -1.016
ENSG00000283050 E035 4.4748669 0.0036167309 6.422620e-04 2.688170e-03 4 119444368 119444368 1 - 0.904 0.476 -1.815
ENSG00000283050 E036 5.8410424 0.0030906647 1.740681e-02 4.583938e-02 4 119444369 119444394 26 - 0.937 0.698 -0.941
ENSG00000283050 E037 8.5824304 0.0020904138 5.106938e-03 1.622087e-02 4 119444395 119444431 37 - 1.085 0.844 -0.900
ENSG00000283050 E038 6.7754633 0.0024722575 2.360386e-02 5.899470e-02 4 119444432 119444433 2 - 0.983 0.777 -0.789
ENSG00000283050 E039 0.5922303 0.0180413040 2.560262e-01 3.929924e-01 4 119444874 119444947 74 - 0.292 0.124 -1.528
ENSG00000283050 E040 0.4439371 0.0215946813 6.552945e-02 1.359226e-01 4 119444948 119445027 80 - 0.292 0.000 -12.913
ENSG00000283050 E041 17.8452178 0.0030148595 1.881335e-04 9.129908e-04 4 119445312 119445527 216 - 1.374 1.135 -0.839
ENSG00000283050 E042 10.6225185 0.0017223346 1.304503e-01 2.347867e-01 4 119448828 119448959 132 - 1.096 1.013 -0.303
ENSG00000283050 E043 0.6632174 0.0201144555 3.789426e-01 5.232360e-01 4 119449374 119449377 4 - 0.120 0.300 1.642
ENSG00000283050 E044 0.8846626 0.0136968632 2.179389e-01 3.479451e-01 4 119449378 119449555 178 - 0.120 0.367 2.059
ENSG00000283050 E045 0.3697384 0.0255094922 2.365104e-01 3.701278e-01 4 119449556 119449566 11 - 0.000 0.221 11.493
ENSG00000283050 E046 6.6072984 0.0728056200 5.589346e-01 6.870959e-01 4 119449567 119450040 474 - 0.904 0.875 -0.110
ENSG00000283050 E047 5.5033542 0.0064290604 1.279917e-01 2.313618e-01 4 119450041 119450041 1 - 0.886 0.751 -0.529
ENSG00000283050 E048 9.8150658 0.0373474754 8.558697e-03 2.518632e-02 4 119450042 119450125 84 - 1.167 0.881 -1.055
ENSG00000283050 E049 3.2329719 0.2350699469 3.972803e-01 5.410364e-01 4 119450126 119450150 25 - 0.713 0.551 -0.704
ENSG00000283050 E050 1.3329548 0.2461450244 2.064579e-01 3.342805e-01 4 119450151 119451235 1085 - 0.465 0.227 -1.483
ENSG00000283050 E051 0.5922303 0.0180413040 2.560262e-01 3.929924e-01 4 119454226 119454245 20 - 0.292 0.124 -1.528
ENSG00000283050 E052 23.7059206 0.0008231826 3.008585e-06 2.250345e-05 4 119454246 119454550 305 - 1.509 1.254 -0.884
ENSG00000283050 E053 11.5511844 0.0015905264 7.548765e-05 4.065993e-04 4 119454551 119454653 103 - 1.237 0.919 -1.154