ENSG00000281706

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000628328 ENSG00000281706 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01012 lncRNA lncRNA 4.388195 3.792928 4.397099 0.1299891 0.09258693 0.2127187 0.8970167 0.4659865 0.7544190 0.03393619 0.18318886 0.6834431 0.19740000 0.12343333 0.17023333 0.046800000 0.66950612 0.03771301   FALSE
ENST00000662411 ENSG00000281706 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01012 lncRNA lncRNA 4.388195 3.792928 4.397099 0.1299891 0.09258693 0.2127187 0.3192312 0.0000000 0.2801806 0.00000000 0.28018064 4.8588794 0.06354583 0.00000000 0.06393333 0.063933333 0.85006929 0.03771301   FALSE
ENST00000687535 ENSG00000281706 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01012 lncRNA lncRNA 4.388195 3.792928 4.397099 0.1299891 0.09258693 0.2127187 0.2645183 0.0000000 0.1257578 0.00000000 0.12575782 3.7629634 0.06186667 0.00000000 0.02756667 0.027566667 0.82679180 0.03771301 FALSE FALSE
ENST00000687781 ENSG00000281706 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01012 lncRNA lncRNA 4.388195 3.792928 4.397099 0.1299891 0.09258693 0.2127187 0.4221882 0.8958372 0.6560889 0.08364622 0.35811154 -0.4435370 0.10547500 0.23760000 0.14693333 -0.090666667 0.54446638 0.03771301   FALSE
ENST00000689802 ENSG00000281706 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01012 lncRNA lncRNA 4.388195 3.792928 4.397099 0.1299891 0.09258693 0.2127187 0.8681974 1.2366243 0.6625936 0.36805398 0.33753008 -0.8902196 0.20939167 0.32010000 0.15336667 -0.166733333 0.61750684 0.03771301   FALSE
ENST00000693575 ENSG00000281706 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01012 lncRNA lncRNA 4.388195 3.792928 4.397099 0.1299891 0.09258693 0.2127187 0.5478463 0.3092761 0.3761211 0.03341505 0.37612112 0.2742490 0.12477083 0.08146667 0.08863333 0.007166667 0.44642761 0.03771301   FALSE
ENST00000693645 ENSG00000281706 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01012 lncRNA lncRNA 4.388195 3.792928 4.397099 0.1299891 0.09258693 0.2127187 0.1111481 0.0000000 0.5742104 0.00000000 0.33816246 5.8684160 0.02383333 0.00000000 0.12883333 0.128833333 0.21813201 0.03771301   FALSE
MSTRG.27860.14 ENSG00000281706 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC01012 lncRNA   4.388195 3.792928 4.397099 0.1299891 0.09258693 0.2127187 0.3519912 0.3178978 0.1279785 0.04168457 0.01658169 -1.2488033 0.07785417 0.08410000 0.02900000 -0.055100000 0.03771301 0.03771301   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000281706 E001 0.6017953 0.1757751548 0.06797945 0.140011121 6 27694027 27694034 8 + 0.356 0.000 -10.597
ENSG00000281706 E002 0.8232405 0.1643731221 0.25863178 0.395935466 6 27694035 27694038 4 + 0.356 0.127 -1.905
ENSG00000281706 E003 0.8232405 0.1643731221 0.25863178 0.395935466 6 27694039 27694042 4 + 0.356 0.127 -1.905
ENSG00000281706 E004 1.1167064 0.0127868817 0.28543855 0.425760855 6 27694043 27694044 2 + 0.412 0.223 -1.239
ENSG00000281706 E005 1.5563771 0.0089322857 0.06307417 0.131830096 6 27694045 27694045 1 + 0.548 0.223 -1.917
ENSG00000281706 E006 2.1046994 0.0071114745 0.19746272 0.323043146 6 27694046 27694052 7 + 0.585 0.369 -1.086
ENSG00000281706 E007 2.1046994 0.0071114745 0.19746272 0.323043146 6 27694053 27694057 5 + 0.585 0.369 -1.086
ENSG00000281706 E008 2.1046994 0.0071114745 0.19746272 0.323043146 6 27694058 27694059 2 + 0.585 0.369 -1.086
ENSG00000281706 E009 2.6153572 0.0059361727 0.37844269 0.522728529 6 27694060 27694067 8 + 0.619 0.479 -0.653
ENSG00000281706 E010 2.6153572 0.0059361727 0.37844269 0.522728529 6 27694068 27694072 5 + 0.619 0.479 -0.653
ENSG00000281706 E011 4.5747821 0.0036155063 0.54660275 0.676759016 6 27694073 27694078 6 + 0.782 0.701 -0.331
ENSG00000281706 E012 5.9356340 0.0031035618 0.87143568 0.921300669 6 27694079 27694084 6 + 0.846 0.826 -0.077
ENSG00000281706 E013 24.2017471 0.0011980878 0.34996062 0.494145361 6 27694085 27694226 142 + 1.364 1.428 0.221
ENSG00000281706 E014 23.5536793 0.0034944043 0.06629994 0.137215829 6 27694227 27694506 280 + 1.455 1.324 -0.453
ENSG00000281706 E015 0.5149242 0.2499507252 0.59317792 0.715623427 6 27694507 27695137 631 + 0.120 0.224 1.088
ENSG00000281706 E016 2.2444823 0.0072438620 0.03861388 0.088474917 6 27699597 27699667 71 + 0.290 0.638 1.820
ENSG00000281706 E017 30.5108000 0.0071275784 0.00153672 0.005755514 6 27702314 27702417 104 + 1.370 1.592 0.762
ENSG00000281706 E018 0.8930831 0.1540613672 0.96795972 0.983972126 6 27702418 27702713 296 + 0.290 0.297 0.047
ENSG00000281706 E019 2.2980465 0.0063533897 0.02260958 0.056940820 6 27706639 27707338 700 + 0.681 0.302 -1.917
ENSG00000281706 E020 1.1103636 0.0117419810 0.28503886 0.425341851 6 27707339 27707416 78 + 0.412 0.223 -1.239
ENSG00000281706 E021 5.4710744 0.0030411068 0.38595666 0.530165689 6 27707417 27709157 1741 + 0.865 0.755 -0.432
ENSG00000281706 E022 20.0685627 0.0010715620 0.11389045 0.211196627 6 27710124 27710225 102 + 1.265 1.382 0.409
ENSG00000281706 E023 41.2418569 0.0007284684 0.17131885 0.289905964 6 27710681 27710853 173 + 1.594 1.664 0.240
ENSG00000281706 E024 26.3860955 0.0009006728 0.16342909 0.279622046 6 27710854 27710889 36 + 1.393 1.484 0.313
ENSG00000281706 E025 8.9387191 0.0019464047 0.01954601 0.050511984 6 27710890 27711089 200 + 1.114 0.867 -0.917
ENSG00000281706 E026 10.4998111 0.0019689202 0.07979323 0.159239269 6 27711090 27711230 141 + 1.145 0.972 -0.631
ENSG00000281706 E027 2.6990311 0.0060332820 0.54106649 0.672105117 6 27711231 27711354 124 + 0.619 0.524 -0.432
ENSG00000281706 E028 62.9385495 0.0004626540 0.72143009 0.815820436 6 27713004 27713706 703 + 1.814 1.801 -0.044