ENSG00000281649

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000625218 ENSG00000281649 HEK293_OSMI2_2hA HEK293_TMG_2hB EBLN3P lncRNA lncRNA 11.40302 3.952763 17.40108 0.4875576 0.8090976 2.135427 1.0291285 0.23142279 1.72108193 0.23142279 1.03883468 2.8420402 0.08339583 0.07290000 0.094633333 0.02173333 7.168982e-01 7.095698e-15   FALSE
ENST00000625445 ENSG00000281649 HEK293_OSMI2_2hA HEK293_TMG_2hB EBLN3P lncRNA lncRNA 11.40302 3.952763 17.40108 0.4875576 0.8090976 2.135427 1.7245191 1.61550541 2.05747800 0.22285857 0.17543914 0.3469836 0.21233333 0.42213333 0.118366667 -0.30376667 2.055648e-04 7.095698e-15   FALSE
ENST00000627197 ENSG00000281649 HEK293_OSMI2_2hA HEK293_TMG_2hB EBLN3P lncRNA lncRNA 11.40302 3.952763 17.40108 0.4875576 0.8090976 2.135427 1.1666868 0.33494528 0.48044591 0.33494528 0.48044591 0.5077265 0.08938333 0.08736667 0.026300000 -0.06106667 8.717682e-01 7.095698e-15 FALSE FALSE
ENST00000628924 ENSG00000281649 HEK293_OSMI2_2hA HEK293_TMG_2hB EBLN3P lncRNA lncRNA 11.40302 3.952763 17.40108 0.4875576 0.8090976 2.135427 0.7808792 0.09104071 1.08537199 0.01322322 0.05246605 3.4384123 0.06454167 0.02390000 0.062333333 0.03843333 2.678607e-02 7.095698e-15   FALSE
ENST00000631093 ENSG00000281649 HEK293_OSMI2_2hA HEK293_TMG_2hB EBLN3P lncRNA lncRNA 11.40302 3.952763 17.40108 0.4875576 0.8090976 2.135427 1.5401382 0.53287197 2.46429128 0.14990879 0.47082569 2.1883314 0.13338333 0.13060000 0.140400000 0.00980000 9.752068e-01 7.095698e-15 FALSE FALSE
ENST00000653711 ENSG00000281649 HEK293_OSMI2_2hA HEK293_TMG_2hB EBLN3P lncRNA lncRNA 11.40302 3.952763 17.40108 0.4875576 0.8090976 2.135427 0.3625046 0.00000000 0.91279744 0.00000000 0.46543854 6.5279421 0.02447083 0.00000000 0.053433333 0.05343333 4.049079e-01 7.095698e-15   FALSE
ENST00000664382 ENSG00000281649 HEK293_OSMI2_2hA HEK293_TMG_2hB EBLN3P lncRNA lncRNA 11.40302 3.952763 17.40108 0.4875576 0.8090976 2.135427 0.3542782 1.05012005 0.08633777 0.60635029 0.08633777 -3.4599823 0.09711667 0.23563333 0.004766667 -0.23086667 1.977696e-01 7.095698e-15   FALSE
ENST00000666604 ENSG00000281649 HEK293_OSMI2_2hA HEK293_TMG_2hB EBLN3P lncRNA lncRNA 11.40302 3.952763 17.40108 0.4875576 0.8090976 2.135427 0.3697686 0.00000000 1.92982227 0.00000000 0.59304983 7.5997807 0.03450000 0.00000000 0.112700000 0.11270000 1.940648e-04 7.095698e-15   FALSE
MSTRG.32657.2 ENSG00000281649 HEK293_OSMI2_2hA HEK293_TMG_2hB EBLN3P lncRNA   11.40302 3.952763 17.40108 0.4875576 0.8090976 2.135427 2.7208417 0.00000000 5.36663943 0.00000000 0.48727133 9.0705609 0.15775833 0.00000000 0.312533333 0.31253333 7.095698e-15 7.095698e-15   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000281649 E001 0.0000000       9 37079645 37079744 100 +      
ENSG00000281649 E002 0.0000000       9 37079840 37079851 12 +      
ENSG00000281649 E003 0.0000000       9 37079852 37079852 1 +      
ENSG00000281649 E004 0.0000000       9 37079853 37079853 1 +      
ENSG00000281649 E005 0.0000000       9 37079854 37079856 3 +      
ENSG00000281649 E006 0.0000000       9 37079857 37079858 2 +      
ENSG00000281649 E007 0.2966881 0.0269973040 1.000000e+00   9 37079859 37079873 15 + 0.123 0.000 -9.684
ENSG00000281649 E008 0.4482035 0.0260939221 5.593539e-01 6.874739e-01 9 37079874 37079879 6 + 0.174 0.000 -11.423
ENSG00000281649 E009 1.6454514 0.0846685650 5.965744e-02 1.260348e-01 9 37079880 37079905 26 + 0.448 0.000 -12.878
ENSG00000281649 E010 1.6454514 0.0846685650 5.965744e-02 1.260348e-01 9 37079906 37079907 2 + 0.448 0.000 -12.878
ENSG00000281649 E011 2.3754675 0.0064230784 1.013221e-02 2.908886e-02 9 37079908 37079913 6 + 0.559 0.000 -13.869
ENSG00000281649 E012 2.8173283 0.0053800077 4.496876e-03 1.453441e-02 9 37079914 37079916 3 + 0.614 0.000 -14.089
ENSG00000281649 E013 4.5135676 0.0034532947 3.716028e-03 1.234313e-02 9 37079917 37079928 12 + 0.760 0.217 -2.876
ENSG00000281649 E014 8.2615309 0.0020464988 1.195273e-04 6.117214e-04 9 37079929 37079934 6 + 0.986 0.361 -2.746
ENSG00000281649 E015 8.4087799 0.0020845993 9.639865e-05 5.051549e-04 9 37079935 37079936 2 + 0.993 0.361 -2.773
ENSG00000281649 E016 11.8516480 0.0015230937 1.644361e-04 8.111211e-04 9 37079937 37079956 20 + 1.118 0.627 -1.906
ENSG00000281649 E017 32.1744003 0.0006801859 4.173401e-06 3.021394e-05 9 37079957 37080030 74 + 1.511 1.164 -1.211
ENSG00000281649 E018 22.3690640 0.0009232405 1.134283e-03 4.418713e-03 9 37080031 37080034 4 + 1.351 1.079 -0.965
ENSG00000281649 E019 19.2101985 0.0011358598 1.601636e-03 5.966443e-03 9 37080035 37080038 4 + 1.290 1.002 -1.031
ENSG00000281649 E020 47.8413045 0.0071063982 1.398179e-02 3.818433e-02 9 37080039 37080341 303 + 1.650 1.505 -0.497
ENSG00000281649 E021 21.2877958 0.0358161800 7.990411e-01 8.717904e-01 9 37080342 37080357 16 + 1.283 1.278 -0.017
ENSG00000281649 E022 54.6251150 0.0005815279 4.592536e-02 1.018988e-01 9 37080358 37080536 179 + 1.693 1.620 -0.246
ENSG00000281649 E023 4.5071231 0.0035369797 8.931510e-02 1.740897e-01 9 37080537 37080858 322 + 0.734 0.468 -1.188
ENSG00000281649 E024 10.2533123 0.0019484416 3.032037e-04 1.392476e-03 9 37080859 37081594 736 + 1.060 0.555 -2.018
ENSG00000281649 E025 4.1928308 0.0490132467 6.024092e-02 1.270168e-01 9 37081595 37081865 271 + 0.721 0.360 -1.724
ENSG00000281649 E026 26.0680221 0.0473744505 4.493286e-03 1.452355e-02 9 37081866 37084198 2333 + 1.425 1.037 -1.373
ENSG00000281649 E027 4.3275082 0.0037289171 2.914727e-02 7.028310e-02 9 37084199 37084292 94 + 0.734 0.360 -1.774
ENSG00000281649 E028 25.2499292 0.0007726834 3.354887e-06 2.485621e-05 9 37084990 37086667 1678 + 1.416 1.002 -1.468
ENSG00000281649 E029 861.4491476 0.0014885513 7.966690e-01 8.702297e-01 9 37086668 37089800 3133 + 2.855 2.896 0.136
ENSG00000281649 E030 96.3424582 0.0085815639 4.401987e-32 8.544500e-30 9 37089801 37090928 1128 + 1.641 2.332 2.324
ENSG00000281649 E031 0.0000000       9 37123185 37123227 43 +