ENSG00000280734

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000625254 ENSG00000280734 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.7242772 0.6156509 0.9033324 0.08925292 0.141504 0.5457823 0.18532629 0.00000000 0.58408494 0.00000000 0.14743114 5.89259731 0.19600417 0.0000000 0.62873333 0.62873333 5.111783e-06 5.111783e-06   FALSE
ENST00000625287 ENSG00000280734 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA retained_intron 0.7242772 0.6156509 0.9033324 0.08925292 0.141504 0.5457823 0.06254792 0.05829498 0.05951795 0.01711535 0.01162332 0.02560597 0.08674167 0.0965000 0.07363333 -0.02286667 8.488297e-01 5.111783e-06 FALSE FALSE
ENST00000626729 ENSG00000280734 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.7242772 0.6156509 0.9033324 0.08925292 0.141504 0.5457823 0.03917324 0.00000000 0.07643852 0.00000000 0.02209142 3.11167439 0.06925000 0.0000000 0.09050000 0.09050000 8.047871e-02 5.111783e-06 FALSE FALSE
ENST00000630421 ENSG00000280734 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.7242772 0.6156509 0.9033324 0.08925292 0.141504 0.5457823 0.06059134 0.13243426 0.03147977 0.02231988 0.01574152 -1.77981644 0.09935833 0.2293667 0.03743333 -0.19193333 3.379405e-02 5.111783e-06   FALSE
ENST00000656995 ENSG00000280734 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.7242772 0.6156509 0.9033324 0.08925292 0.141504 0.5457823 0.35085010 0.42492162 0.15181127 0.08973687 0.08101639 -1.42644333 0.49972917 0.6741000 0.16970000 -0.50440000 2.922154e-02 5.111783e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000280734 E001 1.474715 0.009713178 0.4620309342 0.6019349750 13 99486962 99487816 855 - 0.282 0.419 0.831
ENSG00000280734 E002 0.000000       13 99491468 99491474 7 -      
ENSG00000280734 E003 1.249090 0.111958299 0.7571518883 0.8420619966 13 99491475 99492103 629 - 0.282 0.337 0.363
ENSG00000280734 E004 2.687388 0.025209152 0.4214201651 0.5645766637 13 99492104 99493774 1671 - 0.623 0.491 -0.609
ENSG00000280734 E005 1.218916 0.011090173 0.0930662713 0.1799167915 13 99493775 99494377 603 - 0.516 0.229 -1.713
ENSG00000280734 E006 6.116125 0.003051268 0.1237035041 0.2252276405 13 99494378 99495476 1099 - 0.667 0.875 0.832
ENSG00000280734 E007 3.462252 0.004681487 0.9914308023 0.9987110440 13 99495477 99495817 341 - 0.623 0.628 0.024
ENSG00000280734 E008 1.579191 0.010020991 0.0875692396 0.1714470380 13 99496135 99496217 83 - 0.572 0.285 -1.560
ENSG00000280734 E009 5.426770 0.053487357 0.1109615668 0.2069619866 13 99496418 99496544 127 - 0.573 0.844 1.127
ENSG00000280734 E010 3.608268 0.006386994 0.7714723360 0.8524781688 13 99496698 99496708 11 - 0.623 0.672 0.213
ENSG00000280734 E011 6.452164 0.013535236 0.0728579393 0.1480946550 13 99496709 99496772 64 - 0.667 0.922 1.011
ENSG00000280734 E012 6.949419 0.003132205 0.0380630291 0.0874687855 13 99497249 99497336 88 - 0.667 0.937 1.069
ENSG00000280734 E013 14.793406 0.001516763 0.0001337338 0.0006755406 13 99498686 99499306 621 - 1.342 1.067 -0.975