ENSG00000279088

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000625041 ENSG00000279088 HEK293_OSMI2_2hA HEK293_TMG_2hB   TEC TEC 64.49703 112.5448 46.11297 5.813215 3.007766 -1.28707 13.04450 14.11598 9.546980 1.2726215 0.3707467 -0.5637239 0.2379917 0.1249667 0.2097667 0.0848 0.006587057 0.006587057    
MSTRG.4200.1 ENSG00000279088 HEK293_OSMI2_2hA HEK293_TMG_2hB   TEC   64.49703 112.5448 46.11297 5.813215 3.007766 -1.28707 11.84995 22.67560 8.728292 0.7646489 0.2781845 -1.3763535 0.1780000 0.2020667 0.1906667 -0.0114 0.827322256 0.006587057    
MSTRG.4200.3 ENSG00000279088 HEK293_OSMI2_2hA HEK293_TMG_2hB   TEC   64.49703 112.5448 46.11297 5.813215 3.007766 -1.28707 39.60258 75.75318 27.837697 4.0999838 3.3061444 -1.4439389 0.5840000 0.6729667 0.5995667 -0.0734 0.273015179 0.006587057    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000279088 E001 23.78852 0.0013582167 4.236947e-03 1.380522e-02 10 73742477 73742994 518 - 1.146 1.383 0.833
ENSG00000279088 E002 23.71641 0.0051989624 4.104621e-03 1.343646e-02 10 73742995 73742998 4 - 1.130 1.386 0.900
ENSG00000279088 E003 603.41113 0.0001894506 5.567273e-06 3.920538e-05 10 73742999 73743211 213 - 2.676 2.726 0.165
ENSG00000279088 E004 88.68565 0.0003247397 6.974779e-02 1.429523e-01 10 73743212 73743230 19 - 1.947 1.862 -0.283
ENSG00000279088 E005 353.17321 0.0017773149 8.327846e-11 1.490069e-09 10 73743231 73744216 986 - 2.597 2.437 -0.532
ENSG00000279088 E006 365.58588 0.0014593187 2.978078e-02 7.153299e-02 10 73744217 73744257 41 - 2.465 2.505 0.134