ENSG00000278535

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000610443 ENSG00000278535 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS11 protein_coding retained_intron 21.00655 38.01825 12.0801 0.3176666 0.2168332 -1.653245 1.760425 2.084085 1.1257751 0.1468255 0.04168362 -0.8826428 0.09291667 0.05476667 0.09336667 0.03860000 1.521061e-02 8.69996e-20 FALSE TRUE
ENST00000615432 ENSG00000278535 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS11 protein_coding protein_coding 21.00655 38.01825 12.0801 0.3176666 0.2168332 -1.653245 1.532267 1.038809 0.7690343 0.1907502 0.07306130 -0.4289937 0.09097917 0.02736667 0.06350000 0.03613333 1.755773e-02 8.69996e-20 FALSE FALSE
ENST00000617959 ENSG00000278535 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS11 protein_coding retained_intron 21.00655 38.01825 12.0801 0.3176666 0.2168332 -1.653245 1.837036 3.457428 0.7988981 0.1516566 0.16588885 -2.0998362 0.08610000 0.09100000 0.06586667 -0.02513333 3.995933e-01 8.69996e-20 FALSE TRUE
ENST00000618403 ENSG00000278535 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS11 protein_coding protein_coding 21.00655 38.01825 12.0801 0.3176666 0.2168332 -1.653245 8.322165 14.201610 5.7089985 1.3186263 0.26632390 -1.3132356 0.40030833 0.37300000 0.47363333 0.10063333 2.537631e-01 8.69996e-20 FALSE TRUE
ENST00000621871 ENSG00000278535 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS11 protein_coding protein_coding 21.00655 38.01825 12.0801 0.3176666 0.2168332 -1.653245 2.993374 8.927602 0.0000000 1.4412969 0.00000000 -9.8037440 0.11611250 0.23536667 0.00000000 -0.23536667 8.699960e-20 8.69996e-20 FALSE FALSE
MSTRG.14199.1 ENSG00000278535 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS11 protein_coding   21.00655 38.01825 12.0801 0.3176666 0.2168332 -1.653245 1.768838 1.777431 2.0483758 0.7613611 0.42480471 0.2036187 0.08403333 0.04646667 0.16983333 0.12336667 4.071823e-02 8.69996e-20 FALSE TRUE
MSTRG.14199.2 ENSG00000278535 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS11 protein_coding   21.00655 38.01825 12.0801 0.3176666 0.2168332 -1.653245 1.021316 1.799995 0.8158856 1.0146570 0.46702106 -1.1319723 0.05057083 0.04733333 0.06740000 0.02006667 1.000000e+00 8.69996e-20 FALSE TRUE
MSTRG.14199.6 ENSG00000278535 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS11 protein_coding   21.00655 38.01825 12.0801 0.3176666 0.2168332 -1.653245 1.086335 3.311425 0.0000000 0.3446407 0.00000000 -8.3756583 0.04337917 0.08706667 0.00000000 -0.08706667 1.868388e-18 8.69996e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000278535 E001 4.664911 0.0546968321 3.269124e-02 7.718513e-02 17 36591859 36591871 13 + 0.932 0.576 -1.449
ENSG00000278535 E002 7.454583 0.0144870805 5.557738e-03 1.743960e-02 17 36591872 36591878 7 + 1.090 0.744 -1.315
ENSG00000278535 E003 7.747005 0.0063596610 1.042531e-03 4.105863e-03 17 36591879 36591881 3 + 1.127 0.743 -1.450
ENSG00000278535 E004 8.779005 0.0073013329 2.073563e-04 9.954141e-04 17 36591882 36591886 5 + 1.192 0.773 -1.559
ENSG00000278535 E005 11.691137 0.0267537535 1.342184e-04 6.776813e-04 17 36591887 36591898 12 + 1.321 0.870 -1.637
ENSG00000278535 E006 23.880176 0.0281242939 1.490916e-07 1.464227e-06 17 36591899 36591914 16 + 1.660 1.123 -1.864
ENSG00000278535 E007 40.927787 0.0304330738 2.104996e-06 1.629557e-05 17 36591915 36591988 74 + 1.841 1.393 -1.527
ENSG00000278535 E008 99.654599 0.0087885683 2.824660e-03 9.747771e-03 17 36591989 36592156 168 + 2.041 1.884 -0.527
ENSG00000278535 E009 14.124016 0.0012576030 1.274210e-02 3.530410e-02 17 36594587 36594970 384 + 1.274 1.050 -0.798
ENSG00000278535 E010 40.583826 0.0061934627 6.494389e-01 7.607103e-01 17 36594971 36594973 3 + 1.563 1.540 -0.077
ENSG00000278535 E011 75.107005 0.0141388625 9.323863e-01 9.614036e-01 17 36594974 36595026 53 + 1.806 1.808 0.005
ENSG00000278535 E012 144.352939 0.0014053488 7.044454e-01 8.029835e-01 17 36595027 36595180 154 + 2.091 2.087 -0.012
ENSG00000278535 E013 18.655870 0.0013910699 6.873393e-04 2.853138e-03 17 36596298 36596827 530 + 1.411 1.140 -0.954
ENSG00000278535 E014 73.607300 0.0004870962 1.262351e-07 1.257750e-06 17 36596828 36598162 1335 + 1.954 1.732 -0.747
ENSG00000278535 E015 76.482808 0.0003842828 6.823027e-01 7.857668e-01 17 36598163 36598165 3 + 1.791 1.820 0.098
ENSG00000278535 E016 148.662381 0.0002406232 7.083280e-01 8.060174e-01 17 36598166 36598257 92 + 2.081 2.104 0.075
ENSG00000278535 E017 26.693087 0.0007440918 1.697764e-02 4.488618e-02 17 36598258 36598920 663 + 1.486 1.324 -0.562
ENSG00000278535 E018 205.102794 0.0002015636 2.140642e-01 3.433286e-01 17 36598921 36599050 130 + 2.202 2.247 0.150
ENSG00000278535 E019 73.518288 0.0004058731 2.195783e-01 3.498784e-01 17 36599051 36599670 620 + 1.835 1.788 -0.157
ENSG00000278535 E020 82.938473 0.0107459677 3.974269e-01 5.411815e-01 17 36599671 36599693 23 + 1.798 1.865 0.225
ENSG00000278535 E021 132.555997 0.0058835311 2.208895e-01 3.514987e-01 17 36599694 36599763 70 + 1.995 2.067 0.241
ENSG00000278535 E022 50.272408 0.0156416965 9.592317e-01 9.784500e-01 17 36599764 36599971 208 + 1.622 1.640 0.062
ENSG00000278535 E023 171.053464 0.0002469391 2.481378e-03 8.708265e-03 17 36599972 36600037 66 + 2.077 2.184 0.356
ENSG00000278535 E024 20.066754 0.0537634216 5.345969e-01 6.666301e-01 17 36600038 36600161 124 + 1.160 1.275 0.408
ENSG00000278535 E025 482.431637 0.0030820379 2.216941e-12 5.142560e-11 17 36600162 36600804 643 + 2.439 2.652 0.710