ENSG00000278390

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000616251 ENSG00000278390 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 2.940834 3.150556 2.861015 0.7513489 0.4836553 -0.1386174 0.2564097 0.06834421 0.5006788 0.06834421 0.06477896 2.70451755 0.08990000 0.02366667 0.17816667 0.15450000 5.568372e-02 1.076832e-10   FALSE
ENST00000619407 ENSG00000278390 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 2.940834 3.150556 2.861015 0.7513489 0.4836553 -0.1386174 0.1681081 0.20016425 0.3486763 0.02770036 0.05303015 0.77116506 0.06900000 0.07473333 0.13003333 0.05530000 4.475458e-01 1.076832e-10   FALSE
ENST00000620300 ENSG00000278390 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 2.940834 3.150556 2.861015 0.7513489 0.4836553 -0.1386174 0.3048869 0.10574453 0.6284878 0.10574453 0.15994650 2.46371507 0.14163750 0.03663333 0.25033333 0.21370000 1.301323e-01 1.076832e-10   FALSE
ENST00000660769 ENSG00000278390 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 2.940834 3.150556 2.861015 0.7513489 0.4836553 -0.1386174 0.9750143 1.93147204 0.3622299 0.50417430 0.03558951 -2.38288514 0.35435417 0.60403333 0.13060000 -0.47343333 1.076832e-10 1.076832e-10   FALSE
MSTRG.8638.3 ENSG00000278390 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA   2.940834 3.150556 2.861015 0.7513489 0.4836553 -0.1386174 0.8908171 0.70165621 0.6844244 0.39495120 0.68442439 -0.03536286 0.24680833 0.22280000 0.18070000 -0.04210000 6.314079e-01 1.076832e-10   FALSE
MSTRG.8638.7 ENSG00000278390 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA   2.940834 3.150556 2.861015 0.7513489 0.4836553 -0.1386174 0.2051730 0.14317495 0.2314133 0.07852009 0.16530009 0.65632482 0.05349583 0.03810000 0.09173333 0.05363333 9.337232e-01 1.076832e-10   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000278390 E001 1.039186 0.190920301 8.320304e-01 0.8947157810 13 41132939 41132947 9 + 0.290 0.360 0.441
ENSG00000278390 E002 1.039186 0.190920301 8.320304e-01 0.8947157810 13 41132948 41132949 2 + 0.290 0.360 0.441
ENSG00000278390 E003 1.039186 0.190920301 8.320304e-01 0.8947157810 13 41132950 41132951 2 + 0.290 0.360 0.441
ENSG00000278390 E004 1.039186 0.190920301 8.320304e-01 0.8947157810 13 41132952 41132953 2 + 0.290 0.360 0.441
ENSG00000278390 E005 1.493732 0.292844836 5.961029e-01 0.7180821132 13 41132954 41132958 5 + 0.464 0.357 -0.585
ENSG00000278390 E006 14.715252 0.001871465 2.526978e-03 0.0088435609 13 41132959 41133055 97 + 1.059 1.295 0.841
ENSG00000278390 E007 4.087803 0.004263785 3.118168e-04 0.0014278093 13 41134709 41134762 54 + 0.355 0.886 2.400
ENSG00000278390 E008 14.042473 0.001469863 2.611009e-02 0.0641691444 13 41146427 41146507 81 + 1.082 1.256 0.621
ENSG00000278390 E009 4.486612 0.004512175 5.307468e-05 0.0002971464 13 41146508 41146646 139 + 0.355 0.938 2.600
ENSG00000278390 E010 11.839214 0.002458984 8.919606e-05 0.0004712062 13 41162263 41162403 141 + 1.265 0.904 -1.311
ENSG00000278390 E011 0.000000       13 41162981 41163019 39 +      
ENSG00000278390 E012 1.282516 0.012198908 9.255000e-01 0.9570923968 13 41165551 41165608 58 + 0.355 0.369 0.078
ENSG00000278390 E013 2.507739 0.008311359 1.279744e-03 0.0049093571 13 41175373 41175659 287 + 0.760 0.222 -2.829
ENSG00000278390 E014 2.223850 0.006824366 3.910776e-03 0.0128930244 13 41187231 41187568 338 + 0.709 0.222 -2.623
ENSG00000278390 E015 0.599719 0.122285375 6.287923e-02 0.1315092209 13 41192640 41192835 196 + 0.356 0.000 -10.947
ENSG00000278390 E016 11.215761 0.002017747 6.459094e-04 0.0027014063 13 41235116 41236686 1571 + 1.226 0.904 -1.173