ENSG00000278311

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000613102 ENSG00000278311 HEK293_OSMI2_2hA HEK293_TMG_2hB GGNBP2 protein_coding protein_coding 18.19621 10.35657 24.74675 0.4325398 1.261755 1.255882 6.688878 3.2603677 8.4405746 0.3682472 0.7559315 1.3695966 0.35866250 0.31350000 0.34600000 0.032500000 0.86204348 0.02403569 FALSE TRUE
ENST00000615952 ENSG00000278311 HEK293_OSMI2_2hA HEK293_TMG_2hB GGNBP2 protein_coding protein_coding 18.19621 10.35657 24.74675 0.4325398 1.261755 1.255882 1.287580 0.3904071 2.4615730 0.1080595 0.2283238 2.6258901 0.06982917 0.03823333 0.09953333 0.061300000 0.02403569 0.02403569 FALSE FALSE
ENST00000620927 ENSG00000278311 HEK293_OSMI2_2hA HEK293_TMG_2hB GGNBP2 protein_coding retained_intron 18.19621 10.35657 24.74675 0.4325398 1.261755 1.255882 1.131811 1.5511007 0.8246777 0.8516842 0.3301952 -0.9032724 0.07932917 0.15226667 0.03246667 -0.119800000 0.73420156 0.02403569 FALSE TRUE
MSTRG.14194.1 ENSG00000278311 HEK293_OSMI2_2hA HEK293_TMG_2hB GGNBP2 protein_coding   18.19621 10.35657 24.74675 0.4325398 1.261755 1.255882 6.661118 3.9634382 9.6959237 0.2638523 1.1911650 1.2884776 0.35817917 0.38230000 0.38903333 0.006733333 0.98488979 0.02403569 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000278311 E001 0.1515154 0.0429206543 1.000000e+00   17 36544911 36544911 1 + 0.086 0.000 -8.598
ENSG00000278311 E002 0.4482035 0.0258693245 2.866719e-01 0.4270976468 17 36544912 36544918 7 + 0.219 0.000 -10.179
ENSG00000278311 E003 1.3424206 0.0129720094 1.812246e-02 0.0473917715 17 36544919 36544931 13 + 0.473 0.000 -11.764
ENSG00000278311 E004 31.5421812 0.0009431843 3.328524e-04 0.0015116718 17 36544932 36545097 166 + 1.561 1.319 -0.834
ENSG00000278311 E005 4.6422744 0.1255063347 7.928617e-01 0.8675464788 17 36545504 36545618 115 + 0.732 0.701 -0.125
ENSG00000278311 E006 91.6759043 0.0004001761 3.971226e-05 0.0002290358 17 36545619 36545817 199 + 1.993 1.838 -0.524
ENSG00000278311 E007 27.5246691 0.0007443472 3.726056e-03 0.0123725346 17 36545818 36547747 1930 + 1.351 1.555 0.703
ENSG00000278311 E008 79.1107630 0.0012792496 6.754385e-04 0.0028092780 17 36554820 36554900 81 + 1.927 1.783 -0.486
ENSG00000278311 E009 119.8784746 0.0002908265 1.663590e-04 0.0008195607 17 36557083 36557336 254 + 2.098 1.978 -0.404
ENSG00000278311 E010 88.2103441 0.0003715123 4.638589e-02 0.1027352700 17 36560773 36560871 99 + 1.951 1.881 -0.234
ENSG00000278311 E011 100.8312026 0.0009264737 1.142358e-02 0.0321709902 17 36567663 36567776 114 + 2.017 1.928 -0.297
ENSG00000278311 E012 5.1609975 0.0774434260 4.856267e-01 0.6234914231 17 36576657 36577982 1326 + 0.712 0.842 0.517
ENSG00000278311 E013 130.3665667 0.0003052891 4.422977e-01 0.5839405453 17 36577983 36578186 204 + 2.104 2.090 -0.048
ENSG00000278311 E014 28.2841553 0.0007364338 5.916955e-01 0.7144183297 17 36578187 36578192 6 + 1.432 1.478 0.160
ENSG00000278311 E015 5.3334852 0.0141843631 1.899516e-03 0.0069131597 17 36578193 36579244 1052 + 0.903 0.390 -2.266
ENSG00000278311 E016 142.2126043 0.0004284927 4.534547e-01 0.5941942449 17 36579245 36579419 175 + 2.138 2.125 -0.044
ENSG00000278311 E017 155.2443760 0.0005662293 7.613152e-01 0.8452182448 17 36581344 36581538 195 + 2.170 2.172 0.005
ENSG00000278311 E018 1.7747164 0.0077912058 5.447566e-02 0.1170864902 17 36581539 36582477 939 + 0.532 0.171 -2.312
ENSG00000278311 E019 115.6437235 0.0002504313 2.249563e-02 0.0567126729 17 36585300 36585450 151 + 2.013 2.100 0.292
ENSG00000278311 E020 1.3524354 0.0817642101 5.827121e-01 0.7069951994 17 36585451 36585839 389 + 0.403 0.293 -0.662
ENSG00000278311 E021 83.1670031 0.0003649566 1.089949e-01 0.2040552439 17 36585840 36585892 53 + 1.876 1.950 0.250
ENSG00000278311 E022 108.5299297 0.0002919752 3.365177e-01 0.4803655846 17 36585893 36585965 73 + 2.003 2.047 0.148
ENSG00000278311 E023 1.4132927 0.0151485626 4.353539e-01 0.5775976044 17 36585966 36586049 84 + 0.321 0.468 0.823
ENSG00000278311 E024 107.8568209 0.0018362426 6.485088e-01 0.7599967784 17 36586050 36586133 84 + 2.007 2.036 0.097
ENSG00000278311 E025 97.8006834 0.0080241707 9.806667e-01 0.9918867847 17 36586134 36586198 65 + 1.971 1.982 0.036
ENSG00000278311 E026 10.8196480 0.0084384125 3.930516e-01 0.5369309284 17 36586199 36586827 629 + 1.077 0.988 -0.324
ENSG00000278311 E027 2.6771490 0.2207944040 6.166240e-01 0.7346323624 17 36586936 36586996 61 + 0.586 0.520 -0.304
ENSG00000278311 E028 199.5453288 0.0001895246 1.040183e-03 0.0040981508 17 36586997 36587245 249 + 2.246 2.339 0.311
ENSG00000278311 E029 10.8463323 0.0015834475 2.326677e-04 0.0011027036 17 36587246 36587596 351 + 1.163 0.729 -1.636
ENSG00000278311 E030 206.1038378 0.0061640636 3.020012e-05 0.0001795826 17 36589208 36589848 641 + 2.223 2.409 0.620