ENSG00000278175

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000666906 ENSG00000278175 HEK293_OSMI2_2hA HEK293_TMG_2hB GLIDR lncRNA lncRNA 25.26405 44.11815 18.32859 1.236488 1.386584 -1.266816 3.202631 4.484825 3.1876504 0.3850435 0.08302695 -0.4912528 0.13524167 0.1017333 0.17570000 0.07396667 0.006772417 0.006772417    
ENST00000667968 ENSG00000278175 HEK293_OSMI2_2hA HEK293_TMG_2hB GLIDR lncRNA lncRNA 25.26405 44.11815 18.32859 1.236488 1.386584 -1.266816 8.342349 15.899594 6.1695514 0.5628965 0.70247819 -1.3643230 0.31348333 0.3607667 0.33493333 -0.02583333 0.732019325 0.006772417 FALSE  
ENST00000670314 ENSG00000278175 HEK293_OSMI2_2hA HEK293_TMG_2hB GLIDR lncRNA lncRNA 25.26405 44.11815 18.32859 1.236488 1.386584 -1.266816 2.826320 4.507411 1.7899849 0.6352126 0.27157630 -1.3275112 0.11945000 0.1015333 0.10003333 -0.00150000 0.981213878 0.006772417    
ENST00000687737 ENSG00000278175 HEK293_OSMI2_2hA HEK293_TMG_2hB GLIDR lncRNA lncRNA 25.26405 44.11815 18.32859 1.236488 1.386584 -1.266816 2.675356 4.676663 0.9300811 0.6383741 0.54220739 -2.3177040 0.09455417 0.1061667 0.04800000 -0.05816667 0.572415971 0.006772417    
ENST00000687919 ENSG00000278175 HEK293_OSMI2_2hA HEK293_TMG_2hB GLIDR lncRNA lncRNA 25.26405 44.11815 18.32859 1.236488 1.386584 -1.266816 2.799234 4.929091 2.5628173 0.3331355 0.52028614 -0.9408964 0.11194167 0.1122000 0.13766667 0.02546667 0.650905644 0.006772417    
MSTRG.32716.26 ENSG00000278175 HEK293_OSMI2_2hA HEK293_TMG_2hB GLIDR lncRNA   25.26405 44.11815 18.32859 1.236488 1.386584 -1.266816 1.959454 5.326379 1.1467421 0.9037138 0.09145797 -2.2057939 0.07022917 0.1201333 0.06263333 -0.05750000 0.041876629 0.006772417    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000278175 E001 0.0000000       9 39709535 39709666 132 -      
ENSG00000278175 E002 0.0000000       9 39731339 39732447 1109 -      
ENSG00000278175 E003 0.0000000       9 39748341 39748364 24 -      
ENSG00000278175 E004 0.0000000       9 39748365 39748510 146 -      
ENSG00000278175 E005 0.0000000       9 39748511 39748512 2 -      
ENSG00000278175 E006 0.0000000       9 39748513 39748515 3 -      
ENSG00000278175 E007 0.0000000       9 39748516 39748609 94 -      
ENSG00000278175 E008 0.5503986 0.0207893003 9.455492e-01 0.9698456387 9 39748770 39749458 689 - 0.169 0.160 -0.087
ENSG00000278175 E009 0.0000000       9 39749459 39749494 36 -      
ENSG00000278175 E010 0.5953508 0.0339238605 4.393286e-01 0.5810816126 9 39749495 39749571 77 - 0.290 0.160 -1.095
ENSG00000278175 E011 1.9207283 0.0073871258 4.504359e-01 0.5915314395 9 39749572 39749686 115 - 0.528 0.408 -0.605
ENSG00000278175 E012 0.0000000       9 39776431 39776515 85 -      
ENSG00000278175 E013 0.0000000       9 39776516 39776686 171 -      
ENSG00000278175 E014 0.0000000       9 39776687 39776717 31 -      
ENSG00000278175 E015 0.0000000       9 39776718 39777066 349 -      
ENSG00000278175 E016 0.4513240 0.2431961480 2.640838e-01 0.4020290072 9 39777067 39777542 476 - 0.291 0.086 -2.113
ENSG00000278175 E017 1.0632359 0.0121939523 3.135467e-03 0.0106630192 9 39777543 39778330 788 - 0.585 0.087 -3.674
ENSG00000278175 E018 5.2241932 0.0032058029 1.426015e-01 0.2515800575 9 39778331 39778566 236 - 0.883 0.700 -0.727
ENSG00000278175 E019 0.4741261 0.0208461426 2.137225e-01 0.3429147204 9 39778567 39778580 14 - 0.290 0.087 -2.089
ENSG00000278175 E020 1.1676211 0.0909795942 2.128596e-01 0.3418988833 9 39778581 39778893 313 - 0.462 0.224 -1.490
ENSG00000278175 E021 3.3685661 0.0064504674 4.567952e-03 0.0147319608 9 39778894 39778944 51 - 0.856 0.445 -1.790
ENSG00000278175 E022 0.0000000       9 39803481 39803482 2 -      
ENSG00000278175 E023 2.1263937 0.2084517528 3.152524e-01 0.4580032510 9 39803483 39803542 60 - 0.585 0.409 -0.865
ENSG00000278175 E024 106.6381642 0.0005405293 2.072995e-05 0.0001281314 9 39803543 39803859 317 - 2.076 1.946 -0.438
ENSG00000278175 E025 0.1482932 0.0415066930 1.000000e+00   9 39807361 39807380 20 - 0.000 0.087 10.738
ENSG00000278175 E026 0.1482932 0.0415066930 1.000000e+00   9 39807381 39807389 9 - 0.000 0.087 10.738
ENSG00000278175 E027 0.0000000       9 39807390 39807405 16 -      
ENSG00000278175 E028 0.7738329 0.0407736495 5.941641e-01 0.7164436511 9 39807406 39807694 289 - 0.169 0.276 0.902
ENSG00000278175 E029 0.2955422 0.0291019304 5.640344e-01   9 39807695 39807699 5 - 0.169 0.087 -1.092
ENSG00000278175 E030 7.1661187 0.0067369708 2.183100e-04 0.0010422666 9 39807700 39808557 858 - 1.140 0.718 -1.600
ENSG00000278175 E031 0.1817044 0.0403035225 1.000000e+00   9 39808558 39808559 2 - 0.000 0.088 10.747
ENSG00000278175 E032 0.1817044 0.0403035225 1.000000e+00   9 39808560 39808560 1 - 0.000 0.088 10.747
ENSG00000278175 E033 0.1817044 0.0403035225 1.000000e+00   9 39808561 39808564 4 - 0.000 0.088 10.747
ENSG00000278175 E034 26.3660400 0.0012910683 3.209794e-01 0.4641628787 9 39808565 39808761 197 - 1.331 1.418 0.304
ENSG00000278175 E035 23.0067170 0.0035896707 4.113039e-01 0.5548862985 9 39808762 39808933 172 - 1.280 1.362 0.289
ENSG00000278175 E036 27.2169579 0.0122179160 7.288566e-01 0.8212186293 9 39808934 39809304 371 - 1.418 1.408 -0.035
ENSG00000278175 E037 13.7062118 0.0013369707 6.300480e-01 0.7453009680 9 39809305 39809485 181 - 1.076 1.137 0.220
ENSG00000278175 E038 172.3378044 0.0002545261 9.923048e-01 0.9992765620 9 39809486 39809587 102 - 2.180 2.195 0.050
ENSG00000278175 E039 109.3561448 0.0003494370 8.678020e-02 0.1702524775 9 39809588 39809615 28 - 1.939 2.015 0.254
ENSG00000278175 E040 27.8037863 0.0007850805 3.374808e-01 0.4813709506 9 39809616 39809633 18 - 1.448 1.396 -0.180
ENSG00000278175 E041 25.8331980 0.0008385839 8.863410e-01 0.9313162646 9 39809634 39809730 97 - 1.376 1.380 0.013
ENSG00000278175 E042 230.4112644 0.0066929542 9.082287e-03 0.0264860297 9 39809731 39810128 398 - 2.232 2.345 0.375