ENSG00000277053

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000614592 ENSG00000277053 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IP1 transcribed_unprocessed_pseudogene transcribed_unprocessed_pseudogene 19.93354 19.50424 24.1411 2.029307 0.5947158 0.3075619 2.376934 0.0000000 6.081338 0.00000000 2.42384295 9.250615 0.1021417 0.00000000 0.2513000 0.2513000 6.957794e-09 3.432554e-45 TRUE TRUE
ENST00000616377 ENSG00000277053 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IP1 transcribed_unprocessed_pseudogene processed_transcript 19.93354 19.50424 24.1411 2.029307 0.5947158 0.3075619 1.294341 0.3377941 2.662956 0.10050016 0.28335534 2.942131 0.0630750 0.01696667 0.1107667 0.0938000 1.310269e-08 3.432554e-45 TRUE TRUE
ENST00000618412 ENSG00000277053 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IP1 transcribed_unprocessed_pseudogene retained_intron 19.93354 19.50424 24.1411 2.029307 0.5947158 0.3075619 2.045768 4.5474349 0.000000 0.27611127 0.00000000 -8.832078 0.1177750 0.23740000 0.0000000 -0.2374000 7.300299e-36 3.432554e-45   FALSE
ENST00000621948 ENSG00000277053 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IP1 transcribed_unprocessed_pseudogene retained_intron 19.93354 19.50424 24.1411 2.029307 0.5947158 0.3075619 4.040986 0.4372623 6.325949 0.05065599 0.03647509 3.824368 0.1969125 0.02243333 0.2623667 0.2399333 3.432554e-45 3.432554e-45   FALSE
ENST00000622829 ENSG00000277053 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2IP1 transcribed_unprocessed_pseudogene processed_transcript 19.93354 19.50424 24.1411 2.029307 0.5947158 0.3075619 9.378760 13.9848509 7.628902 1.78533209 2.56667788 -0.873459 0.4803833 0.71356667 0.3153000 -0.3982667 9.558306e-03 3.432554e-45 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000277053 E001 0.3299976 0.0274424043 0.2932072203   7 75185385 75185395 11 - 0.000 0.193 9.620
ENSG00000277053 E002 24.6361803 0.0170547866 0.0047134585 0.0151337295 7 75185396 75186115 720 - 1.217 1.485 0.933
ENSG00000277053 E003 22.4167919 0.0226165534 0.0270605387 0.0661141207 7 75186116 75186527 412 - 1.206 1.435 0.796
ENSG00000277053 E004 2.8429536 0.0059348244 0.1048457697 0.1978653837 7 75186528 75187060 533 - 0.400 0.667 1.271
ENSG00000277053 E005 2.0324898 0.0122832037 0.7937396717 0.8681562029 7 75187061 75187219 159 - 0.514 0.471 -0.210
ENSG00000277053 E006 2.8616161 0.0099046362 0.1078152617 0.2023045857 7 75187220 75187241 22 - 0.400 0.667 1.271
ENSG00000277053 E007 11.1233170 0.0016698908 0.5327572296 0.6650722224 7 75187242 75187295 54 - 1.034 1.097 0.228
ENSG00000277053 E008 52.8299049 0.0004558751 0.2528887457 0.3893233304 7 75188075 75188116 42 - 1.746 1.695 -0.173
ENSG00000277053 E009 91.5899044 0.0005148128 0.6419972464 0.7549202859 7 75189215 75189256 42 - 1.957 1.942 -0.049
ENSG00000277053 E010 3.6578397 0.0519341623 0.0903597391 0.1756866641 7 75189257 75190538 1282 - 0.798 0.515 -1.219
ENSG00000277053 E011 54.0795193 0.0004692978 0.0175132372 0.0460694583 7 75190539 75190567 29 - 1.651 1.763 0.380
ENSG00000277053 E012 10.3093129 0.0302712161 0.0001701352 0.0008355782 7 75190568 75191533 966 - 1.264 0.786 -1.765
ENSG00000277053 E013 89.7591161 0.0004560835 0.9545056870 0.9754759634 7 75192047 75192230 184 - 1.940 1.939 -0.003
ENSG00000277053 E014 0.8116123 0.1213389638 0.4739518710 0.6128298133 7 75192899 75192980 82 - 0.329 0.194 -1.011
ENSG00000277053 E015 1.0716670 0.0133484992 0.4447717993 0.5863244246 7 75193903 75193983 81 - 0.400 0.265 -0.846
ENSG00000277053 E016 1.5834576 0.0199617358 0.2851665240 0.4254724784 7 75194657 75194712 56 - 0.514 0.327 -1.014
ENSG00000277053 E017 2.7378285 0.2370609630 0.2777360946 0.4173498238 7 75196613 75196667 55 - 0.712 0.431 -1.293
ENSG00000277053 E018 2.8808111 0.0140378523 0.0476481472 0.1049945163 7 75196668 75196796 129 - 0.743 0.429 -1.428
ENSG00000277053 E019 2.3325019 0.0067088783 0.0172048150 0.0453949191 7 75196974 75197039 66 - 0.712 0.327 -1.888
ENSG00000277053 E020 3.1280902 0.0050320853 0.6774766660 0.7821827236 7 75197948 75198049 102 - 0.643 0.580 -0.276
ENSG00000277053 E021 2.2455145 0.0067331784 0.3861663540 0.5303575968 7 75199651 75199670 20 - 0.400 0.547 0.742
ENSG00000277053 E022 2.5796661 0.0087862982 0.6892163964 0.7911352616 7 75199671 75199725 55 - 0.514 0.580 0.306
ENSG00000277053 E023 0.0000000       7 75199726 75199808 83 -      
ENSG00000277053 E024 0.0000000       7 75199809 75200120 312 -      
ENSG00000277053 E025 1.8015668 0.0114762505 0.8490021286 0.9062889146 7 75200121 75200179 59 - 0.460 0.429 -0.165
ENSG00000277053 E026 3.9061895 0.0042779189 0.9307415869 0.9604186313 7 75201121 75201304 184 - 0.679 0.692 0.056
ENSG00000277053 E027 0.1451727 0.0428405841 0.3695388883   7 75201305 75201316 12 - 0.139 0.000 -12.298
ENSG00000277053 E028 0.0000000       7 75201554 75201718 165 -      
ENSG00000277053 E029 0.0000000       7 75201865 75201923 59 -      
ENSG00000277053 E030 0.8889184 0.0135273925 0.0418161585 0.0943886593 7 75202542 75202613 72 - 0.461 0.107 -2.752
ENSG00000277053 E031 0.0000000       7 75205995 75206260 266 -      
ENSG00000277053 E032 1.3651329 0.0710910679 0.4723101800 0.6113412999 7 75207956 75208014 59 - 0.460 0.324 -0.766
ENSG00000277053 E033 3.8665505 0.0042920315 0.4689696658 0.6082975337 7 75209376 75209559 184 - 0.743 0.640 -0.429
ENSG00000277053 E034 1.1436731 0.0111222147 0.9873963092 0.9961883562 7 75210528 75210599 72 - 0.329 0.327 -0.014
ENSG00000277053 E035 0.9651910 0.0130858426 0.2402048911 0.3743632235 7 75212079 75212137 59 - 0.400 0.193 -1.428
ENSG00000277053 E036 1.7253960 0.0084161773 0.0456613738 0.1014127983 7 75213406 75213589 184 - 0.604 0.265 -1.843
ENSG00000277053 E037 0.9127647 0.0157529402 0.2417175195 0.3762131032 7 75215756 75215821 66 - 0.400 0.193 -1.429
ENSG00000277053 E038 0.6266857 0.0180381951 0.7673032550 0.8495723000 7 75217154 75217264 111 - 0.244 0.193 -0.430
ENSG00000277053 E039 0.4418608 0.0248568602 0.0477948877 0.1052554267 7 75237293 75237694 402 - 0.329 0.000 -13.813
ENSG00000277053 E040 0.0000000       7 75237695 75237696 2 -      
ENSG00000277053 E041 0.0000000       7 75243466 75243609 144 -