ENSG00000276550

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000614571 ENSG00000276550 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2P2 transcribed_unprocessed_pseudogene processed_transcript 16.35486 10.60484 12.46015 1.896067 1.042218 0.2323952 2.8476283 0.8949539 3.1528182 0.19233955 0.3741287 1.8052945 0.17672917 0.08376667 0.25226667 0.16850000 7.531460e-08 7.53146e-08   FALSE
ENST00000615156 ENSG00000276550 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2P2 transcribed_unprocessed_pseudogene processed_transcript 16.35486 10.60484 12.46015 1.896067 1.042218 0.2323952 1.5686518 0.6784036 1.0752610 0.06890018 0.2515672 0.6567154 0.09380833 0.06780000 0.08460000 0.01680000 7.266788e-01 7.53146e-08 TRUE FALSE
ENST00000619021 ENSG00000276550 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2P2 transcribed_unprocessed_pseudogene processed_transcript 16.35486 10.60484 12.46015 1.896067 1.042218 0.2323952 0.5033143 0.7270633 0.0000000 0.18711322 0.0000000 -6.2037167 0.03515000 0.07383333 0.00000000 -0.07383333 1.552387e-07 7.53146e-08 TRUE TRUE
ENST00000690192 ENSG00000276550 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2P2 transcribed_unprocessed_pseudogene processed_transcript 16.35486 10.60484 12.46015 1.896067 1.042218 0.2323952 3.4166228 4.4122237 1.4117644 0.83069556 0.3186103 -1.6370896 0.21590000 0.41696667 0.11146667 -0.30550000 9.912694e-08 7.53146e-08 TRUE TRUE
MSTRG.10313.12 ENSG00000276550 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2P2 transcribed_unprocessed_pseudogene   16.35486 10.60484 12.46015 1.896067 1.042218 0.2323952 0.8902691 0.1685932 0.6455372 0.16859319 0.4393389 1.8760005 0.05020000 0.01170000 0.04903333 0.03733333 6.396556e-01 7.53146e-08 TRUE TRUE
MSTRG.10313.13 ENSG00000276550 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2P2 transcribed_unprocessed_pseudogene   16.35486 10.60484 12.46015 1.896067 1.042218 0.2323952 2.0503962 1.0292701 2.2224512 0.39238291 0.3478933 1.1030579 0.12666667 0.09106667 0.17960000 0.08853333 1.321839e-01 7.53146e-08 TRUE TRUE
MSTRG.10313.16 ENSG00000276550 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2P2 transcribed_unprocessed_pseudogene   16.35486 10.60484 12.46015 1.896067 1.042218 0.2323952 1.9873238 1.6938313 1.4702346 0.36757809 0.1102033 -0.2029567 0.12207917 0.15776667 0.12090000 -0.03686667 4.175271e-01 7.53146e-08 TRUE TRUE
MSTRG.10313.3 ENSG00000276550 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2P2 transcribed_unprocessed_pseudogene   16.35486 10.60484 12.46015 1.896067 1.042218 0.2323952 0.8541102 0.3020714 1.2072962 0.04623182 0.1683705 1.9637320 0.05621667 0.02920000 0.09896667 0.06976667 1.996451e-03 7.53146e-08 TRUE TRUE
MSTRG.10313.8 ENSG00000276550 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2P2 transcribed_unprocessed_pseudogene   16.35486 10.60484 12.46015 1.896067 1.042218 0.2323952 0.2964558 0.5603293 0.0000000 0.24871274 0.0000000 -5.8337233 0.02017083 0.05430000 0.00000000 -0.05430000 1.150158e-03 7.53146e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000276550 E001 0.0000000       15 22494841 22494847 7 +      
ENSG00000276550 E002 0.0000000       15 22494848 22494855 8 +      
ENSG00000276550 E003 0.0000000       15 22494856 22494863 8 +      
ENSG00000276550 E004 0.9244060 0.0133171671 1.317950e-01 2.366180e-01 15 22494864 22494870 7 + 0.397 0.132 -2.079
ENSG00000276550 E005 1.0716550 0.0114694968 7.567282e-02 1.525836e-01 15 22494871 22494872 2 + 0.446 0.132 -2.342
ENSG00000276550 E006 1.3640767 0.0096292304 2.464270e-02 6.114585e-02 15 22494873 22494874 2 + 0.531 0.132 -2.757
ENSG00000276550 E007 3.0788767 0.3498412106 1.362163e-01 2.427796e-01 15 22494875 22494899 25 + 0.761 0.386 -1.736
ENSG00000276550 E008 6.7807487 0.0024646756 9.512812e-02 1.830697e-01 15 22494900 22494955 56 + 0.972 0.775 -0.756
ENSG00000276550 E009 7.2173110 0.0023469748 8.398947e-02 1.657920e-01 15 22495570 22495672 103 + 0.999 0.800 -0.756
ENSG00000276550 E010 4.0440666 0.0142670477 1.293010e-01 2.332056e-01 15 22516876 22516908 33 + 0.805 0.583 -0.928
ENSG00000276550 E011 5.3541186 0.0029680031 4.833625e-02 1.062192e-01 15 22516909 22516990 82 + 0.913 0.657 -1.020
ENSG00000276550 E012 10.3301764 0.0017133829 5.797310e-02 1.231563e-01 15 22534068 22534243 176 + 1.132 0.944 -0.689
ENSG00000276550 E013 15.3896687 0.0011428400 2.483899e-02 6.154504e-02 15 22537438 22537608 171 + 1.291 1.103 -0.666
ENSG00000276550 E014 3.6848366 0.0180254715 4.565089e-02 1.013933e-01 15 22537993 22538096 104 + 0.805 0.494 -1.344
ENSG00000276550 E015 0.0000000       15 22539090 22539096 7 +      
ENSG00000276550 E016 0.9244060 0.0133171671 1.317950e-01 2.366180e-01 15 22539097 22539247 151 + 0.397 0.132 -2.079
ENSG00000276550 E017 2.1487212 0.0397262722 7.420971e-02 1.502742e-01 15 22541995 22542209 215 + 0.633 0.314 -1.635
ENSG00000276550 E018 10.3532409 0.0017195419 3.026025e-01 4.444929e-01 15 22542483 22542615 133 + 1.092 0.994 -0.360
ENSG00000276550 E019 18.4858694 0.0147105857 2.401324e-01 3.742945e-01 15 22542723 22542850 128 + 1.330 1.224 -0.371
ENSG00000276550 E020 23.1629869 0.0009785789 3.043365e-01 4.463444e-01 15 22542943 22543138 196 + 1.407 1.340 -0.231
ENSG00000276550 E021 18.1932870 0.0040085699 2.623285e-02 6.442153e-02 15 22545767 22545900 134 + 1.353 1.172 -0.636
ENSG00000276550 E022 18.8766388 0.0461921766 1.249804e-01 2.271017e-01 15 22546430 22546600 171 + 1.365 1.197 -0.591
ENSG00000276550 E023 8.2529849 0.2173696713 2.804027e-01 4.202680e-01 15 22546678 22546820 143 + 1.038 0.857 -0.680
ENSG00000276550 E024 3.2078175 0.2479918243 1.280763e-01 2.314881e-01 15 22546938 22547089 152 + 0.784 0.382 -1.851
ENSG00000276550 E025 0.0000000       15 22547852 22547880 29 +      
ENSG00000276550 E026 10.5418728 0.0135586984 2.303581e-02 5.782515e-02 15 22547881 22548072 192 + 1.178 0.925 -0.924
ENSG00000276550 E027 17.5737281 0.0077285402 5.392472e-02 1.161291e-01 15 22554385 22554572 188 + 1.347 1.180 -0.587
ENSG00000276550 E028 11.4530180 0.0015673290 9.777491e-01 9.901728e-01 15 22556012 22556204 193 + 1.082 1.091 0.034
ENSG00000276550 E029 3.9146972 0.0042460682 7.147621e-01 8.108695e-01 15 22556910 22556912 3 + 0.662 0.720 0.243
ENSG00000276550 E030 23.3810594 0.0008713446 1.771007e-01 2.974634e-01 15 22556913 22557092 180 + 1.422 1.333 -0.308
ENSG00000276550 E031 31.2553827 0.0016264764 1.418802e-02 3.865225e-02 15 22559789 22559970 182 + 1.567 1.418 -0.511
ENSG00000276550 E032 23.3417890 0.0156756955 7.195223e-01 8.143289e-01 15 22560788 22560935 148 + 1.386 1.367 -0.064
ENSG00000276550 E033 10.2004491 0.0176485098 4.475831e-03 1.447404e-02 15 22560936 22560997 62 + 1.186 0.847 -1.250
ENSG00000276550 E034 10.4739739 0.0203604596 3.876328e-05 2.241386e-04 15 22560998 22561059 62 + 1.242 0.722 -1.946
ENSG00000276550 E035 9.5797595 0.0218918026 6.455696e-06 4.481175e-05 15 22561060 22561121 62 + 1.227 0.623 -2.309
ENSG00000276550 E036 11.7229152 0.0212108734 2.640553e-01 4.020027e-01 15 22561122 22561183 62 + 1.142 1.030 -0.407
ENSG00000276550 E037 12.3522303 0.0086622399 2.209387e-01 3.515582e-01 15 22561184 22561257 74 + 1.169 1.054 -0.415
ENSG00000276550 E038 34.2314322 0.0039442140 8.724515e-01 9.219747e-01 15 22561258 22561433 176 + 1.530 1.550 0.067
ENSG00000276550 E039 21.7552223 0.0008823951 3.425260e-01 4.865195e-01 15 22561434 22561454 21 + 1.311 1.387 0.266
ENSG00000276550 E040 35.3269538 0.0042784974 5.400719e-01 6.712657e-01 15 22561559 22561789 231 + 1.526 1.576 0.168
ENSG00000276550 E041 7.1608822 0.0023915341 2.604411e-01 3.979694e-01 15 22561790 22561895 106 + 0.972 0.846 -0.477
ENSG00000276550 E042 7.4857702 0.0023115379 2.112846e-01 3.400091e-01 15 22561896 22561934 39 + 0.986 0.846 -0.527
ENSG00000276550 E043 1.5134246 0.0131998898 2.230008e-01 3.539565e-01 15 22562643 22562731 89 + 0.278 0.495 1.242
ENSG00000276550 E044 21.1724381 0.0009311734 2.984719e-02 7.166361e-02 15 22562949 22563087 139 + 1.242 1.412 0.592
ENSG00000276550 E045 25.2261674 0.0008161643 9.849031e-02 1.881960e-01 15 22564389 22564532 144 + 1.341 1.462 0.419
ENSG00000276550 E046 15.2223577 0.0284626977 1.718818e-01 2.906563e-01 15 22566305 22566362 58 + 1.093 1.276 0.651
ENSG00000276550 E047 34.3155989 0.0024098585 3.022231e-02 7.240719e-02 15 22569149 22569291 143 + 1.460 1.603 0.490
ENSG00000276550 E048 59.1681735 0.0004596994 9.406020e-01 9.666865e-01 15 22572929 22573181 253 + 1.769 1.779 0.035
ENSG00000276550 E049 45.7871134 0.0005257824 8.982100e-01 9.390542e-01 15 22573279 22573402 124 + 1.659 1.659 0.002
ENSG00000276550 E050 31.1917913 0.0007152883 4.414927e-01 5.831338e-01 15 22573403 22573415 13 + 1.519 1.478 -0.140
ENSG00000276550 E051 30.8626395 0.0006907202 2.273436e-01 3.592274e-01 15 22573975 22574073 99 + 1.530 1.462 -0.234
ENSG00000276550 E052 0.2214452 0.0358461547 4.223514e-01   15 22574660 22574712 53 + 0.000 0.132 9.014
ENSG00000276550 E053 0.0000000       15 22576115 22576205 91 +      
ENSG00000276550 E054 2.3970314 0.0284971326 6.113321e-01 7.304424e-01 15 22576759 22577158 400 + 0.490 0.582 0.431
ENSG00000276550 E055 12.1233936 0.0015983209 3.238544e-01 4.671864e-01 15 22577159 22577332 174 + 1.060 1.160 0.362
ENSG00000276550 E056 7.9527352 0.0670983799 6.408732e-01 7.540288e-01 15 22577430 22577555 126 + 0.913 1.000 0.325
ENSG00000276550 E057 0.0000000       15 22579348 22579477 130 +      
ENSG00000276550 E058 12.1291247 0.0867749191 8.586108e-01 9.127862e-01 15 22579584 22579678 95 + 1.103 1.147 0.158
ENSG00000276550 E059 14.0377368 0.0565724261 9.093456e-01 9.464235e-01 15 22579679 22579723 45 + 1.187 1.181 -0.022
ENSG00000276550 E060 0.0000000       15 22579724 22579813 90 +      
ENSG00000276550 E061 23.8064228 0.0497128555 9.792249e-01 9.910670e-01 15 22587344 22587391 48 + 1.392 1.407 0.051
ENSG00000276550 E062 6.5616099 0.0139919791 5.890633e-03 1.832345e-02 15 22587392 22587876 485 + 1.024 0.658 -1.433
ENSG00000276550 E063 34.6899746 0.0022674053 2.203826e-01 3.508649e-01 15 22589680 22589942 263 + 1.503 1.586 0.286
ENSG00000276550 E064 198.2332032 0.0022794140 2.522126e-18 1.322472e-16 15 22589943 22590820 878 + 2.132 2.409 0.924