ENSG00000276293

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000613767 ENSG00000276293 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP4K2B protein_coding processed_transcript 21.42395 23.25308 18.85003 0.7385927 0.292682 -0.3027103 1.798133 0.330816 1.390129 0.1663786 0.3838572 2.0384943 0.08597083 0.0140000 0.0734000 0.0594 1.269046e-01 8.464875e-07 FALSE FALSE
ENST00000619039 ENSG00000276293 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP4K2B protein_coding protein_coding 21.42395 23.25308 18.85003 0.7385927 0.292682 -0.3027103 18.508630 22.124908 16.004265 0.6766659 0.2352857 -0.4669658 0.86029583 0.9515333 0.8494333 -0.1021 8.464875e-07 8.464875e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000276293 E001 2348.9065256 0.0063810886 2.531013e-07 2.378555e-06 17 38765691 38769771 4081 - 3.247 3.437 0.630
ENSG00000276293 E002 157.2203734 0.0008649825 2.291150e-05 1.400844e-04 17 38770436 38770539 104 - 2.206 2.180 -0.084
ENSG00000276293 E003 151.2766307 0.0010329611 5.033313e-02 1.097567e-01 17 38771014 38771173 160 - 2.150 2.193 0.143
ENSG00000276293 E004 135.1027036 0.0030236487 7.124287e-02 1.453999e-01 17 38771174 38771272 99 - 2.109 2.143 0.115
ENSG00000276293 E005 2.1702861 0.0067950204 4.480401e-01 5.893656e-01 17 38776604 38776625 22 - 0.376 0.576 1.004
ENSG00000276293 E006 174.1663751 0.0003535163 8.805602e-05 4.658461e-04 17 38777687 38777800 114 - 2.239 2.237 -0.007
ENSG00000276293 E007 114.5331056 0.0011812552 3.881623e-04 1.729043e-03 17 38778334 38778372 39 - 2.067 2.044 -0.079
ENSG00000276293 E008 154.8558993 0.0030305340 1.605640e-05 1.017848e-04 17 38779383 38779529 147 - 2.217 2.158 -0.195
ENSG00000276293 E009 2.6592772 0.0056367878 1.470413e-01 2.576588e-01 17 38779852 38779930 79 - 0.648 0.498 -0.682
ENSG00000276293 E010 2.5465576 0.0220450307 3.721442e-01 5.166049e-01 17 38780447 38780451 5 - 0.575 0.500 -0.353
ENSG00000276293 E011 103.6950739 0.0044459860 1.146108e-05 7.513292e-05 17 38780452 38780552 101 - 2.065 1.966 -0.333
ENSG00000276293 E012 81.8833141 0.0015217586 4.058360e-04 1.797205e-03 17 38780553 38780604 52 - 1.937 1.892 -0.152
ENSG00000276293 E013 94.3308949 0.0042913557 6.586972e-04 2.747308e-03 17 38784243 38784339 97 - 2.003 1.947 -0.188
ENSG00000276293 E014 95.2292385 0.0016193057 7.902411e-05 4.232649e-04 17 38786823 38786920 98 - 2.007 1.954 -0.179
ENSG00000276293 E015 0.5202097 0.0206027066 3.799819e-01 5.242468e-01 17 38792726 38792882 157 - 0.228 0.117 -1.164
ENSG00000276293 E016 106.3806390 0.0067962638 2.072855e-04 9.951751e-04 17 38799266 38799556 291 - 2.071 1.986 -0.285
ENSG00000276293 E017 0.1482932 0.0415443786 6.694760e-01   17 38799984 38800126 143 - 0.000 0.116 13.416