ENSG00000276141

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000611636 ENSG00000276141 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene transcribed_unprocessed_pseudogene 1.29641 0.4674324 1.574713 0.1201592 0.1202489 1.730853 0.1426919 0.01774469 0.40283530 0.01774469 0.02969814 3.8952828 0.1000417 0.02510000 0.2601667 0.235066667 0.01686764 0.01686764 TRUE TRUE
ENST00000612263 ENSG00000276141 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene retained_intron 1.29641 0.4674324 1.574713 0.1201592 0.1202489 1.730853 0.3933258 0.11221355 0.31519732 0.06774912 0.10942721 1.4119111 0.2665250 0.21213333 0.1917667 -0.020366667 0.92025675 0.01686764   FALSE
ENST00000621139 ENSG00000276141 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 1.29641 0.4674324 1.574713 0.1201592 0.1202489 1.730853 0.1437154 0.11416423 0.09300975 0.11416423 0.04938783 -0.2694687 0.1636875 0.31780000 0.0642000 -0.253600000 0.97871901 0.01686764 TRUE TRUE
ENST00000622062 ENSG00000276141 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene retained_intron 1.29641 0.4674324 1.574713 0.1201592 0.1202489 1.730853 0.1539811 0.03130428 0.16553954 0.01020487 0.01716537 2.0874328 0.1139250 0.06556667 0.1056000 0.040033333 0.71778410 0.01686764   FALSE
MSTRG.10312.3 ENSG00000276141 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   1.29641 0.4674324 1.574713 0.1201592 0.1202489 1.730853 0.2144846 0.12302342 0.25877623 0.12302342 0.03148264 1.0147253 0.1775708 0.17393333 0.1653000 -0.008633333 0.90523590 0.01686764   FALSE
MSTRG.10312.5 ENSG00000276141 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   1.29641 0.4674324 1.574713 0.1201592 0.1202489 1.730853 0.2482114 0.06898219 0.33935461 0.06898219 0.05550744 2.1450930 0.1782458 0.20550000 0.2130000 0.007500000 0.68111010 0.01686764 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000276141 E001 0.4375944 0.028906843 0.3865524303 0.5307339291 15 22664359 22664678 320 + 0.210 0.000 -9.798
ENSG00000276141 E002 1.7694058 0.008494983 0.0106651590 0.0303690366 15 22664679 22664960 282 + 0.542 0.000 -12.893
ENSG00000276141 E003 0.4396707 0.061024444 0.3908081000 0.5347592785 15 22664961 22665127 167 + 0.210 0.000 -11.567
ENSG00000276141 E004 0.4460135 0.063514037 0.3910638765 0.5350091199 15 22665128 22665267 140 + 0.210 0.000 -11.565
ENSG00000276141 E005 0.5943067 0.027860830 1.0000000000 1.0000000000 15 22665268 22665334 67 + 0.210 0.179 -0.284
ENSG00000276141 E006 2.1475633 0.007335922 0.2360738347 0.3696277543 15 22667898 22668054 157 + 0.542 0.306 -1.281
ENSG00000276141 E007 3.3226745 0.005117639 0.1157764781 0.2139174689 15 22671457 22671607 151 + 0.693 0.404 -1.359
ENSG00000276141 E008 0.5181333 0.021110698 0.8119802172 0.8807136997 15 22672307 22672465 159 + 0.151 0.180 0.306
ENSG00000276141 E009 9.3184429 0.002146932 0.2792519212 0.4189807212 15 22672690 22672859 170 + 1.031 0.884 -0.550
ENSG00000276141 E010 0.4439371 0.022108543 0.3843816626 0.5285348995 15 22672860 22674420 1561 + 0.210 0.000 -11.608
ENSG00000276141 E011 5.4335142 0.003591149 0.8101683997 0.8795116217 15 22674421 22674586 166 + 0.805 0.748 -0.227
ENSG00000276141 E012 0.0000000       15 22674587 22675118 532 +      
ENSG00000276141 E013 2.9999751 0.005746056 0.4347567959 0.5770612189 15 22676805 22676934 130 + 0.635 0.483 -0.697
ENSG00000276141 E014 5.3362509 0.011821591 0.5473933605 0.6774501066 15 22678197 22678383 187 + 0.819 0.706 -0.452
ENSG00000276141 E015 0.1451727 0.045191222 1.0000000000   15 22681094 22681175 82 + 0.082 0.000 -10.328
ENSG00000276141 E016 4.2888209 0.004091084 0.8963031436 0.9377204788 15 22681176 22681262 87 + 0.711 0.707 -0.019
ENSG00000276141 E017 4.0328040 0.004406383 0.4240235732 0.5670179068 15 22681517 22681605 89 + 0.655 0.748 0.385
ENSG00000276141 E018 4.2835103 0.003801262 0.7621787830 0.8458437312 15 22681606 22681885 280 + 0.728 0.661 -0.282
ENSG00000276141 E019 24.7016890 0.001161867 0.0001782154 0.0008702542 15 22683672 22686213 2542 + 1.315 1.501 0.640