ENSG00000276043

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000613817 ENSG00000276043 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF1 protein_coding protein_coding 57.6072 68.80112 51.77224 3.244286 0.146498 -0.4101845 8.726807 28.13258 0.000000 4.3404668 0.000000 -11.4585388 0.1342833 0.4047667 0.0000000 -0.40476667 5.098264e-45 5.098264e-45 FALSE TRUE
ENST00000615884 ENSG00000276043 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF1 protein_coding protein_coding 57.6072 68.80112 51.77224 3.244286 0.146498 -0.4101845 13.309496 14.01839 9.380785 0.5274244 1.127022 -0.5790318 0.2361750 0.2039333 0.1813000 -0.02263333 7.042752e-01 5.098264e-45 FALSE TRUE
ENST00000650932 ENSG00000276043 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF1 protein_coding protein_coding 57.6072 68.80112 51.77224 3.244286 0.146498 -0.4101845 31.351667 25.27026 40.386899 1.3555681 1.146358 0.6762334 0.5566208 0.3707333 0.7800333 0.40930000 1.017627e-11 5.098264e-45 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000276043 E001 0.1515154 0.0434135268 4.415606e-01   19 4903080 4903645 566 + 0.122 0.000 -10.797
ENSG00000276043 E002 2.1014903 0.0070642648 3.025993e-01 4.444916e-01 19 4909430 4909497 68 + 0.556 0.420 -0.669
ENSG00000276043 E003 2.1014903 0.0070642648 3.025993e-01 4.444916e-01 19 4909498 4909500 3 + 0.556 0.420 -0.669
ENSG00000276043 E004 128.9670415 0.0093993033 1.770049e-07 1.713983e-06 19 4909501 4909655 155 + 2.228 1.982 -0.823
ENSG00000276043 E005 1.3201556 0.2725520816 2.407327e-01 3.750363e-01 19 4910116 4910145 30 + 0.468 0.224 -1.521
ENSG00000276043 E006 28.2821956 0.0009370980 2.623967e-01 4.001825e-01 19 4910146 4910246 101 + 1.471 1.449 -0.075
ENSG00000276043 E007 0.1482932 0.0412716580 5.402198e-01   19 4910367 4910374 8 + 0.000 0.122 10.539
ENSG00000276043 E008 1.1426264 0.0125804800 1.139042e-02 3.209746e-02 19 4910375 4910494 120 + 0.000 0.471 13.130
ENSG00000276043 E009 4.9630933 0.0033233577 4.449356e-01 5.865077e-01 19 4910495 4910875 381 + 0.690 0.837 0.593
ENSG00000276043 E010 318.8517451 0.0024725670 1.017412e-10 1.792649e-09 19 4910876 4911038 163 + 2.576 2.431 -0.484
ENSG00000276043 E011 525.9216378 0.0015337085 1.630970e-09 2.324749e-08 19 4929222 4929476 255 + 2.766 2.679 -0.290
ENSG00000276043 E012 407.7314892 0.0001995709 7.154807e-11 1.293745e-09 19 4930716 4930876 161 + 2.643 2.579 -0.213
ENSG00000276043 E013 480.0068653 0.0006319865 5.012772e-11 9.316733e-10 19 4932741 4932956 216 + 2.720 2.646 -0.245
ENSG00000276043 E014 289.8926819 0.0002523387 9.811732e-09 1.211973e-07 19 4941528 4941628 101 + 2.498 2.429 -0.231
ENSG00000276043 E015 299.5093755 0.0006337308 3.158418e-04 1.444076e-03 19 4941745 4941907 163 + 2.492 2.462 -0.101
ENSG00000276043 E016 146.5174255 0.0002676844 6.109277e-03 1.889595e-02 19 4941908 4941931 24 + 2.183 2.156 -0.091
ENSG00000276043 E017 269.5436764 0.0007330674 2.602364e-04 1.217729e-03 19 4944132 4944255 124 + 2.449 2.413 -0.122
ENSG00000276043 E018 195.0294703 0.0011816934 8.957579e-04 3.599123e-03 19 4944343 4944369 27 + 2.314 2.268 -0.152
ENSG00000276043 E019 225.5950623 0.0005553215 1.509434e-03 5.666683e-03 19 4944370 4944450 81 + 2.368 2.340 -0.092
ENSG00000276043 E020 164.3627607 0.0002540971 1.689761e-01 2.868537e-01 19 4945861 4945965 105 + 2.209 2.225 0.051
ENSG00000276043 E021 246.1560300 0.0001890623 1.312533e-01 2.358935e-01 19 4947105 4947211 107 + 2.380 2.400 0.064
ENSG00000276043 E022 354.9024902 0.0014205806 7.102895e-01 8.074879e-01 19 4950611 4950773 163 + 2.525 2.568 0.144
ENSG00000276043 E023 408.4070023 0.0029915004 5.166944e-01 6.512323e-01 19 4950859 4950996 138 + 2.591 2.624 0.108
ENSG00000276043 E024 307.4472371 0.0002033538 1.904951e-02 4.944390e-02 19 4954350 4954488 139 + 2.428 2.530 0.342
ENSG00000276043 E025 214.5790790 0.0002376178 2.397817e-08 2.752419e-07 19 4954650 4954822 173 + 2.215 2.410 0.649
ENSG00000276043 E026 106.9959194 0.0002933007 1.569247e-01 2.709995e-01 19 4956709 4956813 105 + 1.972 2.075 0.344
ENSG00000276043 E027 1350.4697326 0.0046901632 5.079163e-28 7.207732e-26 19 4960657 4962154 1498 + 2.884 3.263 1.261