ENSG00000275131

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000637601 ENSG00000275131 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 1.272682 0.6483353 1.223698 0.04977883 0.04187889 0.9060954 0.38007910 0.23039549 0.2755000 0.02322796 0.01907076 0.2480807 0.29814583 0.36573333 0.2259333 -0.1398000 0.42075746 0.03766252 TRUE TRUE
MSTRG.1966.1 ENSG00000275131 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   1.272682 0.6483353 1.223698 0.04977883 0.04187889 0.9060954 0.52560722 0.38654000 0.3587749 0.07397419 0.11247481 -0.1047258 0.44963750 0.58516667 0.2941667 -0.2910000 0.18644283 0.03766252 TRUE TRUE
MSTRG.1966.3 ENSG00000275131 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   1.272682 0.6483353 1.223698 0.04977883 0.04187889 0.9060954 0.14938592 0.01294451 0.2763869 0.01294451 0.08009043 3.6417444 0.09884583 0.02343333 0.2249667 0.2015333 0.03766252 0.03766252 TRUE TRUE
MSTRG.1966.6 ENSG00000275131 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   1.272682 0.6483353 1.223698 0.04977883 0.04187889 0.9060954 0.08741267 0.00000000 0.1899922 0.00000000 0.09598426 4.3218715 0.06313333 0.00000000 0.1576333 0.1576333 0.30225131 0.03766252 TRUE TRUE
MSTRG.1966.8 ENSG00000275131 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   1.272682 0.6483353 1.223698 0.04977883 0.04187889 0.9060954 0.03369870 0.00000000 0.1078710 0.00000000 0.10787097 3.5591365 0.02704167 0.00000000 0.0853000 0.0853000 0.90378340 0.03766252 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000275131 E001 2.9182586 0.033496055 0.47204920 0.61112054 1 120470800 120471033 234 - 0.516 0.639 0.557
ENSG00000275131 E002 6.5516063 0.003144236 0.02387631 0.05955151 1 120489811 120489859 49 - 0.723 0.996 1.056
ENSG00000275131 E003 6.5181805 0.065314955 0.03065811 0.07324841 1 120489860 120489916 57 - 0.673 1.015 1.336
ENSG00000275131 E004 6.2657428 0.002745323 0.05149745 0.11181063 1 120491582 120491628 47 - 0.723 0.962 0.931
ENSG00000275131 E005 1.2596890 0.010988995 0.28037017 0.42023741 1 120491897 120491934 38 - 0.433 0.241 -1.207
ENSG00000275131 E006 9.7487830 0.002152996 0.02799871 0.06800958 1 120491935 120492073 139 - 0.895 1.122 0.839
ENSG00000275131 E007 5.8690205 0.004292890 0.00791000 0.02355173 1 120493158 120493301 144 - 0.617 0.963 1.381
ENSG00000275131 E008 1.5500449 0.009308477 0.47374771 0.61265819 1 120494234 120494460 227 - 0.331 0.456 0.701
ENSG00000275131 E009 0.3697384 0.027442404 0.13866230 0.24624950 1 120495030 120495146 117 - 0.000 0.241 12.199
ENSG00000275131 E010 0.1482932 0.042258692 0.38261214   1 120497182 120497421 240 - 0.000 0.137 11.195
ENSG00000275131 E011 0.2214452 0.036435167 0.38187014   1 120501110 120501206 97 - 0.000 0.137 11.202
ENSG00000275131 E012 0.2214452 0.036435167 0.38187014   1 120501207 120501234 28 - 0.000 0.137 11.202
ENSG00000275131 E013 2.3230361 0.080280452 0.98156562 0.99253635 1 120501928 120502117 190 - 0.516 0.511 -0.025
ENSG00000275131 E014 4.8308825 0.062532653 0.39279342 0.53670323 1 120503600 120503719 120 - 0.673 0.824 0.612
ENSG00000275131 E015 5.5199233 0.003179995 0.20442447 0.33169258 1 120504382 120504513 132 - 0.723 0.885 0.642
ENSG00000275131 E016 5.6014838 0.002965231 0.94508380 0.96955726 1 120505711 120505962 252 - 0.808 0.817 0.038
ENSG00000275131 E017 0.0000000       1 120509485 120509670 186 -      
ENSG00000275131 E018 3.7903651 0.004557949 0.99669364 1.00000000 1 120511666 120511818 153 - 0.673 0.673 0.001
ENSG00000275131 E019 3.7213683 0.061207169 0.22319612 0.35420717 1 120512470 120512693 224 - 0.767 0.555 -0.907
ENSG00000275131 E020 1.8455897 0.007892776 0.18626088 0.30905955 1 120513766 120513817 52 - 0.553 0.325 -1.207
ENSG00000275131 E021 3.9846427 0.004260675 0.72243611 0.81653975 1 120514825 120515060 236 - 0.723 0.673 -0.207
ENSG00000275131 E022 4.0180553 0.004423266 0.35644975 0.50081830 1 120516824 120517352 529 - 0.767 0.637 -0.541
ENSG00000275131 E023 0.6934950 0.035705526 0.79703596 0.87049770 1 120518530 120518649 120 - 0.196 0.242 0.383
ENSG00000275131 E024 0.8450104 0.015926755 0.87428957 0.92317038 1 120519218 120519410 193 - 0.269 0.241 -0.205
ENSG00000275131 E025 0.4847352 0.244032788 0.77623607 0.85592778 1 120519468 120519690 223 - 0.197 0.137 -0.623
ENSG00000275131 E026 0.1472490 0.042511770 0.61484134   1 120519691 120519731 41 - 0.109 0.000 -10.717
ENSG00000275131 E027 0.4460135 0.024794834 0.13151384 0.23625202 1 120519732 120519821 90 - 0.269 0.000 -12.302
ENSG00000275131 E028 3.0476530 0.005522935 0.55763428 0.68600575 1 120520234 120520563 330 - 0.646 0.556 -0.399
ENSG00000275131 E029 1.5834456 0.008783550 0.11985116 0.21977305 1 120520564 120520669 106 - 0.516 0.241 -1.621
ENSG00000275131 E030 0.0000000       1 120522099 120522162 64 -      
ENSG00000275131 E031 2.6708934 0.009152512 0.08979480 0.17481521 1 120523894 120524126 233 - 0.673 0.395 -1.322
ENSG00000275131 E032 9.9976174 0.002018943 0.09424718 0.18176282 1 120528387 120530295 1909 - 0.954 1.122 0.615
ENSG00000275131 E033 4.4618918 0.025951149 0.20912629 0.33748764 1 120530296 120530384 89 - 0.827 0.636 -0.780
ENSG00000275131 E034 4.4597018 0.100977753 0.32244473 0.46574429 1 120531878 120532089 212 - 0.827 0.633 -0.794
ENSG00000275131 E035 1.3555664 0.010376918 0.07299994 0.14833396 1 120536311 120536402 92 - 0.196 0.509 1.963
ENSG00000275131 E036 2.0209619 0.072779157 0.37246155 0.51692813 1 120538323 120538404 82 - 0.385 0.557 0.870
ENSG00000275131 E037 4.7877196 0.003602038 0.37625154 0.52060157 1 120538571 120538735 165 - 0.699 0.817 0.478
ENSG00000275131 E038 6.7600324 0.002694163 0.71802734 0.81326247 1 120541892 120542078 187 - 0.862 0.906 0.167
ENSG00000275131 E039 3.0064025 0.082186878 0.45835940 0.59869149 1 120542079 120542086 8 - 0.647 0.514 -0.600
ENSG00000275131 E040 0.0000000       1 120543006 120543016 11 -      
ENSG00000275131 E041 5.7970210 0.003165053 0.57087101 0.69729978 1 120543017 120543196 180 - 0.862 0.792 -0.274
ENSG00000275131 E042 5.4972150 0.003140629 0.06794991 0.13996397 1 120543947 120544084 138 - 0.910 0.673 -0.944
ENSG00000275131 E043 5.2380907 0.003148692 0.11869334 0.21807238 1 120544267 120544380 114 - 0.879 0.673 -0.823
ENSG00000275131 E044 5.6195591 0.003220097 0.02870255 0.06941219 1 120545281 120545439 159 - 0.925 0.638 -1.151
ENSG00000275131 E045 3.3290001 0.027752015 0.45692514 0.59729546 1 120548289 120548501 213 - 0.673 0.558 -0.506
ENSG00000275131 E046 1.4122486 0.010461802 0.53484537 0.66683614 1 120548641 120548733 93 - 0.433 0.325 -0.623
ENSG00000275131 E047 3.7279109 0.004612215 0.39436080 0.53821722 1 120548973 120549092 120 - 0.723 0.599 -0.528
ENSG00000275131 E048 4.4922686 0.003730623 0.21896372 0.34914880 1 120550145 120550276 132 - 0.808 0.638 -0.699
ENSG00000275131 E049 9.9056087 0.001919219 0.02737748 0.06675911 1 120557019 120557503 485 - 1.132 0.906 -0.833
ENSG00000275131 E050 0.4418608 0.026918351 0.13159649 0.23635792 1 120558770 120558800 31 - 0.269 0.000 -12.302
ENSG00000275131 E051 0.0000000       1 120573072 120573189 118 -      
ENSG00000275131 E052 0.0000000       1 120578706 120578881 176 -      
ENSG00000275131 E053 0.0000000       1 120579071 120579194 124 -      
ENSG00000275131 E054 0.0000000       1 120620355 120620465 111 -      
ENSG00000275131 E055 0.0000000       1 120641608 120641759 152 -      
ENSG00000275131 E056 0.0000000       1 120646873 120646928 56 -      
ENSG00000275131 E057 0.0000000       1 120701057 120701289 233 -