ENSG00000275111

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000614034 ENSG00000275111 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF2 protein_coding protein_coding 3.571067 3.675265 3.336853 0.3211999 0.07597134 -0.1389632 2.7043901 3.17775519 2.4224654 0.39137421 0.05898383 -0.3901216 0.75430417 0.8593 0.72686667 -0.13243333 0.17262806 0.02961594 FALSE  
ENST00000617923 ENSG00000275111 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF2 protein_coding protein_coding 3.571067 3.675265 3.336853 0.3211999 0.07597134 -0.1389632 0.6067809 0.31594626 0.6334677 0.05222493 0.16149587 0.9812336 0.16803333 0.0870 0.18870000 0.10170000 0.16811926 0.02961594 FALSE  
MSTRG.18857.1 ENSG00000275111 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF2 protein_coding   3.571067 3.675265 3.336853 0.3211999 0.07597134 -0.1389632 0.1422879 0.03898276 0.2332287 0.02498748 0.04816597 2.3119677 0.04132917 0.0096 0.07006667 0.06046667 0.02961594 0.02961594 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000275111 E001 0.1451727 0.043350138 0.4263080116   2 95164937 95165431 495 + 0.123 0.000 -10.730
ENSG00000275111 E002 2.1328015 0.008052700 0.0021059945 0.007552613 2 95165432 95165465 34 + 0.694 0.216 -2.612
ENSG00000275111 E003 7.5558308 0.002313799 0.0004860535 0.002106788 2 95165466 95165788 323 + 1.085 0.741 -1.307
ENSG00000275111 E004 3.3838941 0.004831083 0.0944124598 0.182001298 2 95165789 95165808 20 + 0.748 0.553 -0.836
ENSG00000275111 E005 3.4663971 0.022260874 0.0751776577 0.151819440 2 95165809 95165816 8 + 0.773 0.552 -0.944
ENSG00000275111 E006 16.6164899 0.010557361 0.8303471601 0.893544820 2 95165817 95165860 44 + 1.207 1.291 0.295
ENSG00000275111 E007 18.8044075 0.007799903 0.7000776365 0.799631585 2 95176188 95176259 72 + 1.249 1.345 0.336
ENSG00000275111 E008 32.8677396 0.005183960 0.2088145711 0.337090471 2 95177483 95177609 127 + 1.546 1.528 -0.063
ENSG00000275111 E009 0.7458221 0.018922314 0.1205703659 0.220782290 2 95180156 95180158 3 + 0.364 0.121 -2.029
ENSG00000275111 E010 34.6539480 0.005179744 0.0840314549 0.165848929 2 95180159 95180272 114 + 1.581 1.536 -0.155
ENSG00000275111 E011 0.5202097 0.021470101 0.4781843350 0.616635839 2 95181064 95181102 39 + 0.219 0.122 -1.025
ENSG00000275111 E012 299.0659549 0.016594945 0.0240488597 0.059914548 2 95181103 95184317 3215 + 2.414 2.520 0.355