ENSG00000275052

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000611717 ENSG00000275052 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP4R3B protein_coding protein_coding 17.00695 4.392685 26.55294 0.1872045 0.7549359 2.592959 1.0798983 0.77514037 0.9358269 0.36419430 0.1704101 0.2686256 0.11014167 0.17193333 0.03550000 -0.13643333 4.580655e-02 6.421257e-37 FALSE TRUE
ENST00000612688 ENSG00000275052 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP4R3B protein_coding processed_transcript 17.00695 4.392685 26.55294 0.1872045 0.7549359 2.592959 0.9380681 0.73216290 1.4563532 0.13532385 0.1169214 0.9824249 0.08268333 0.16546667 0.05483333 -0.11063333 1.076564e-04 6.421257e-37 TRUE FALSE
ENST00000616288 ENSG00000275052 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP4R3B protein_coding protein_coding 17.00695 4.392685 26.55294 0.1872045 0.7549359 2.592959 5.6819082 0.00000000 8.7860219 0.00000000 0.2146410 9.7807074 0.24139167 0.00000000 0.33103333 0.33103333 6.421257e-37 6.421257e-37 FALSE TRUE
ENST00000616407 ENSG00000275052 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP4R3B protein_coding protein_coding 17.00695 4.392685 26.55294 0.1872045 0.7549359 2.592959 2.7430758 0.68342041 5.2462297 0.34440050 0.3280194 2.9222261 0.14030417 0.15956667 0.19763333 0.03806667 8.165841e-01 6.421257e-37 FALSE TRUE
MSTRG.18430.10 ENSG00000275052 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP4R3B protein_coding   17.00695 4.392685 26.55294 0.1872045 0.7549359 2.592959 1.1407758 0.00000000 2.5019968 0.00000000 0.1225728 7.9726908 0.04548750 0.00000000 0.09450000 0.09450000 6.620035e-11 6.421257e-37 FALSE TRUE
MSTRG.18430.7 ENSG00000275052 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP4R3B protein_coding   17.00695 4.392685 26.55294 0.1872045 0.7549359 2.592959 0.8911461 0.07287437 2.0162573 0.07287437 0.2697644 4.6117476 0.03761667 0.01813333 0.07550000 0.05736667 1.653430e-01 6.421257e-37 FALSE TRUE
MSTRG.18430.8 ENSG00000275052 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP4R3B protein_coding   17.00695 4.392685 26.55294 0.1872045 0.7549359 2.592959 4.0942856 1.76632587 5.1553434 0.20131419 0.5690110 1.5399680 0.28687917 0.40560000 0.19340000 -0.21220000 7.020403e-03 6.421257e-37 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000275052 E001 17.0996060 0.0021927167 3.505619e-06 2.585473e-05 2 55547292 55547450 159 - 1.018 1.484 1.644
ENSG00000275052 E002 54.2858424 0.0088252972 1.808010e-08 2.124695e-07 2 55547451 55547732 282 - 1.506 1.939 1.469
ENSG00000275052 E003 70.2349549 0.0117108975 1.855140e-05 1.159712e-04 2 55547733 55548377 645 - 1.640 1.987 1.170
ENSG00000275052 E004 371.3686515 0.0008397454 4.321629e-21 3.148922e-19 2 55548378 55549569 1192 - 2.376 2.641 0.884
ENSG00000275052 E005 54.0635533 0.0010930626 4.076585e-01 5.512508e-01 2 55549570 55549612 43 - 1.583 1.676 0.313
ENSG00000275052 E006 179.6243322 0.0068050914 9.701416e-01 9.853232e-01 2 55549613 55550006 394 - 2.107 2.147 0.133
ENSG00000275052 E007 135.0138379 0.0042677503 5.260397e-01 6.593199e-01 2 55558775 55558968 194 - 1.992 1.998 0.018
ENSG00000275052 E008 121.6313085 0.0007627803 1.270653e-01 2.300494e-01 2 55564313 55564470 158 - 1.953 1.922 -0.106
ENSG00000275052 E009 54.9998963 0.0004537041 9.623093e-03 2.783732e-02 2 55564471 55564476 6 - 1.629 1.484 -0.496
ENSG00000275052 E010 52.2319875 0.0004754179 1.733430e-02 4.567805e-02 2 55564477 55564497 21 - 1.606 1.472 -0.457
ENSG00000275052 E011 108.9252378 0.0003187627 1.205894e-03 4.660594e-03 2 55564902 55565041 140 - 1.915 1.790 -0.420
ENSG00000275052 E012 0.8073328 0.0157475230 1.558816e-01 2.696209e-01 2 55568029 55568193 165 - 0.139 0.429 2.161
ENSG00000275052 E013 123.5711929 0.0002745240 1.321222e-03 5.047827e-03 2 55568194 55568363 170 - 1.968 1.856 -0.376
ENSG00000275052 E014 109.8173536 0.0007789591 1.305317e-05 8.437570e-05 2 55573619 55573777 159 - 1.927 1.733 -0.655
ENSG00000275052 E015 67.4101367 0.0004031616 1.880662e-03 6.854979e-03 2 55577315 55577356 42 - 1.715 1.551 -0.559
ENSG00000275052 E016 59.6720005 0.0005531832 5.736129e-01 6.995534e-01 2 55578247 55578342 96 - 1.641 1.643 0.009
ENSG00000275052 E017 84.6588086 0.0004106943 6.771319e-03 2.062887e-02 2 55579679 55579781 103 - 1.806 1.691 -0.390
ENSG00000275052 E018 95.4963586 0.0003368440 1.819153e-04 8.861059e-04 2 55581567 55581698 132 - 1.865 1.698 -0.564
ENSG00000275052 E019 82.5052162 0.0003051070 3.013778e-06 2.253873e-05 2 55585051 55585167 117 - 1.811 1.561 -0.848
ENSG00000275052 E020 94.2084474 0.0002887725 6.052807e-08 6.412875e-07 2 55586618 55586734 117 - 1.871 1.590 -0.950
ENSG00000275052 E021 83.5291779 0.0003211610 7.954385e-06 5.405267e-05 2 55588879 55588956 78 - 1.814 1.581 -0.792
ENSG00000275052 E022 2.5364462 0.0473772986 3.104966e-01 4.529073e-01 2 55591505 55591568 64 - 0.479 0.265 -1.261
ENSG00000275052 E023 116.4222420 0.0002483118 1.054027e-07 1.066451e-06 2 55598416 55598697 282 - 1.956 1.719 -0.797
ENSG00000275052 E024 34.0765202 0.0005854076 9.381992e-03 2.723803e-02 2 55598698 55598703 6 - 1.432 1.231 -0.700
ENSG00000275052 E025 136.3601105 0.0002589832 1.500311e-09 2.152764e-08 2 55598704 55599039 336 - 2.026 1.772 -0.853
ENSG00000275052 E026 81.2306366 0.0028013217 2.820881e-07 2.625049e-06 2 55603978 55604076 99 - 1.810 1.485 -1.105
ENSG00000275052 E027 75.4744160 0.0146804899 2.576395e-13 6.909547e-12 2 55614176 55615450 1275 - 1.597 2.162 1.906
ENSG00000275052 E028 67.0255359 0.0004252154 7.266876e-04 2.994818e-03 2 55615451 55615506 56 - 1.715 1.530 -0.631
ENSG00000275052 E029 14.3927532 0.0013517538 5.603600e-21 4.031847e-19 2 55616518 55616617 100 - 0.742 1.635 3.220
ENSG00000275052 E030 193.9714633 0.0129408349 2.670137e-01 4.052858e-01 2 55617144 55617978 835 - 2.129 2.247 0.396
ENSG00000275052 E031 1.3412721 0.0676163143 2.358605e-02 5.896030e-02 2 55617979 55618065 87 - 0.177 0.641 2.746
ENSG00000275052 E032 4.4753929 0.2033470506 3.055558e-02 7.305781e-02 2 55618066 55618094 29 - 0.497 1.030 2.182
ENSG00000275052 E033 17.7522327 0.0013841597 9.307913e-08 9.504426e-07 2 55618095 55618750 656 - 1.002 1.519 1.824
ENSG00000275052 E034 6.6779758 0.0393904235 7.707218e-02 1.548021e-01 2 55618751 55619758 1008 - 0.690 1.013 1.256