ENSG00000274265

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000612135 ENSG00000274265 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 1.89925 2.454139 3.040632 0.1525792 0.1532168 0.3080248 0.1215824 0.00000000 0.4744799 0.00000000 0.16896326 5.5983650 0.05452083 0.00000000 0.15676667 0.156766667 0.0005047912 0.0005047912   FALSE
ENST00000655610 ENSG00000274265 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 1.89925 2.454139 3.040632 0.1525792 0.1532168 0.3080248 0.1216034 0.06007326 0.1001792 0.04452753 0.05129624 0.6529160 0.08285833 0.02396667 0.03133333 0.007366667 0.9025984204 0.0005047912 FALSE FALSE
ENST00000667654 ENSG00000274265 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 1.89925 2.454139 3.040632 0.1525792 0.1532168 0.3080248 0.6016493 0.91149309 1.1328715 0.10613917 0.27564871 0.3106180 0.27210833 0.37313333 0.36656667 -0.006566667 0.9955689232 0.0005047912 FALSE FALSE
ENST00000668239 ENSG00000274265 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 1.89925 2.454139 3.040632 0.1525792 0.1532168 0.3080248 0.8532319 1.33559752 1.0586752 0.14185194 0.04835083 -0.3324235 0.48985833 0.54163333 0.35173333 -0.189900000 0.0439277994 0.0005047912 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000274265 E001 0.8179419 0.016125401 0.631517752 0.74650194 1 149175748 149175769 22 + 0.300 0.215 -0.634
ENSG00000274265 E002 3.0560972 0.005988131 0.760368944 0.84451410 1 149175770 149175889 120 + 0.634 0.589 -0.201
ENSG00000274265 E003 2.9088481 0.006485644 0.944754694 0.96930400 1 149175890 149175892 3 + 0.600 0.589 -0.049
ENSG00000274265 E004 2.9088481 0.006485644 0.944754694 0.96930400 1 149175893 149175897 5 + 0.600 0.589 -0.049
ENSG00000274265 E005 3.1302933 0.005725980 0.872754066 0.92217609 1 149175898 149175943 46 + 0.600 0.623 0.103
ENSG00000274265 E006 4.0933934 0.004839497 0.739395154 0.82908379 1 149175944 149176021 78 + 0.667 0.713 0.194
ENSG00000274265 E007 4.4642908 0.008340852 0.749763154 0.83662135 1 149176022 149176040 19 + 0.697 0.740 0.177
ENSG00000274265 E008 15.4039183 0.001277509 0.692291757 0.79356566 1 149176041 149176182 142 + 1.192 1.222 0.107
ENSG00000274265 E009 17.0507489 0.001350883 0.640796128 0.75398057 1 149176183 149176250 68 + 1.236 1.269 0.118
ENSG00000274265 E010 0.0000000       1 149176551 149176601 51 +      
ENSG00000274265 E011 6.2280823 0.003033726 0.543967528 0.67449105 1 149177158 149177212 55 + 0.900 0.830 -0.272
ENSG00000274265 E012 0.0000000       1 149177213 149178213 1001 +      
ENSG00000274265 E013 1.4478498 0.011747823 0.295626878 0.43676936 1 149180296 149180547 252 + 0.475 0.292 -1.049
ENSG00000274265 E014 0.0000000       1 149180548 149180611 64 +      
ENSG00000274265 E015 0.1472490 0.056066372 0.464832613   1 149181062 149182153 1092 + 0.124 0.000 -10.600
ENSG00000274265 E016 0.5922303 0.018747970 0.294435866 0.43553722 1 149190636 149190795 160 + 0.299 0.120 -1.635
ENSG00000274265 E017 0.2924217 0.028703986 0.189482297   1 149191147 149191268 122 + 0.221 0.000 -11.527
ENSG00000274265 E018 14.2262896 0.037268726 0.399722448 0.54345970 1 149250565 149251069 505 + 1.122 1.227 0.375
ENSG00000274265 E019 1.4987540 0.012710016 0.006383666 0.01962058 1 149259502 149259987 486 + 0.600 0.121 -3.218