ENSG00000273749

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000561263 ENSG00000273749 HEK293_OSMI2_2hA HEK293_TMG_2hB CYFIP1 protein_coding protein_coding 30.95873 30.44925 31.39274 1.994813 1.032614 0.04401012 2.196255 3.2904196 1.210661 0.4958239 0.2038720 -1.434986604 0.07121667 0.10813333 0.0389000 -0.06923333 0.004151229 0.004151229 FALSE  
ENST00000611832 ENSG00000273749 HEK293_OSMI2_2hA HEK293_TMG_2hB CYFIP1 protein_coding protein_coding 30.95873 30.44925 31.39274 1.994813 1.032614 0.04401012 1.655303 0.3228126 2.812444 0.1629820 0.8329852 3.084162984 0.05258333 0.01123333 0.0881000 0.07686667 0.107423081 0.004151229 FALSE  
MSTRG.10320.4 ENSG00000273749 HEK293_OSMI2_2hA HEK293_TMG_2hB CYFIP1 protein_coding   30.95873 30.44925 31.39274 1.994813 1.032614 0.04401012 25.003074 25.1084077 25.050203 1.8476869 0.4147064 -0.003346916 0.80736667 0.82373333 0.7991333 -0.02460000 0.723137523 0.004151229 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000273749 E001 0.8920389 0.0143244920 3.499781e-01 4.941620e-01 15 22867052 22867124 73 - 0.372 0.211 -1.113
ENSG00000273749 E002 29.1181270 0.0007789784 3.066602e-02 7.326547e-02 15 22867125 22869465 2341 - 1.542 1.411 -0.450
ENSG00000273749 E003 577.5024472 0.0029986253 9.551690e-17 4.121957e-15 15 22869466 22870192 727 - 2.600 2.852 0.841
ENSG00000273749 E004 9.3353529 0.0018713676 7.761362e-02 1.556322e-01 15 22872637 22872824 188 - 0.890 1.089 0.737
ENSG00000273749 E005 330.2470537 0.0012915421 7.389332e-06 5.058126e-05 15 22872825 22872972 148 - 2.445 2.569 0.412
ENSG00000273749 E006 336.5338134 0.0009483002 4.163010e-09 5.500556e-08 15 22873491 22873680 190 - 2.437 2.588 0.501
ENSG00000273749 E007 158.0470407 0.0029530738 2.445900e-08 2.802688e-07 15 22873681 22873729 49 - 2.060 2.286 0.756
ENSG00000273749 E008 246.4768175 0.0013563143 1.200584e-08 1.458835e-07 15 22874550 22874644 95 - 2.289 2.460 0.573
ENSG00000273749 E009 220.7229797 0.0003813977 8.403509e-07 7.094724e-06 15 22875199 22875271 73 - 2.265 2.399 0.446
ENSG00000273749 E010 0.5117019 0.0227864132 9.998325e-02 1.904686e-01 15 22875272 22875462 191 - 0.000 0.288 11.305
ENSG00000273749 E011 286.3304275 0.0005551608 3.325784e-05 1.955857e-04 15 22879913 22880043 131 - 2.396 2.503 0.354
ENSG00000273749 E012 243.4292011 0.0005379497 2.084800e-04 1.000302e-03 15 22881846 22881936 91 - 2.329 2.430 0.338
ENSG00000273749 E013 284.2203770 0.0003576154 5.917252e-01 7.144246e-01 15 22882868 22883011 144 - 2.444 2.465 0.069
ENSG00000273749 E014 235.4773532 0.0004287513 9.338616e-01 9.623124e-01 15 22892890 22892977 88 - 2.368 2.379 0.035
ENSG00000273749 E015 211.0647440 0.0026152856 9.517682e-01 9.737939e-01 15 22903706 22903757 52 - 2.319 2.326 0.021
ENSG00000273749 E016 305.6252294 0.0015506378 7.540136e-01 8.397546e-01 15 22903758 22903905 148 - 2.485 2.482 -0.011
ENSG00000273749 E017 2.4378149 0.0065633667 1.512436e-01 2.633684e-01 15 22903906 22905440 1535 - 0.372 0.616 1.212
ENSG00000273749 E018 243.1648791 0.0009300881 9.738591e-01 9.877116e-01 15 22909194 22909313 120 - 2.382 2.388 0.020
ENSG00000273749 E019 197.8872898 0.0001936451 6.528711e-01 7.634958e-01 15 22910520 22910628 109 - 2.298 2.295 -0.011
ENSG00000273749 E020 191.3697919 0.0002136284 3.179097e-01 4.608212e-01 15 22910737 22910813 77 - 2.292 2.274 -0.059
ENSG00000273749 E021 232.6739099 0.0002283859 3.337059e-03 1.125449e-02 15 22912179 22912275 97 - 2.399 2.338 -0.205
ENSG00000273749 E022 1.0287911 0.0130204408 9.107003e-01 9.472509e-01 15 22912276 22912386 111 - 0.304 0.288 -0.108
ENSG00000273749 E023 237.0146881 0.0002143467 5.289537e-03 1.672012e-02 15 22914726 22914826 101 - 2.406 2.349 -0.190
ENSG00000273749 E024 155.5454295 0.0018704278 5.856940e-01 7.093411e-01 15 22914827 22914882 56 - 2.198 2.185 -0.044
ENSG00000273749 E025 0.5202097 0.0211305680 5.171853e-01 6.516308e-01 15 22914883 22915103 221 - 0.224 0.119 -1.108
ENSG00000273749 E026 90.7014616 0.0003338610 9.913715e-01 9.986675e-01 15 22916477 22916482 6 - 1.954 1.962 0.026
ENSG00000273749 E027 188.1506478 0.0008091217 1.181562e-01 2.172959e-01 15 22916483 22916630 148 - 2.295 2.257 -0.126
ENSG00000273749 E028 4.3771857 0.0065806159 3.577039e-02 8.314001e-02 15 22916631 22916881 251 - 0.871 0.582 -1.188
ENSG00000273749 E029 4.3876691 0.2168701826 1.218483e-01 2.225567e-01 15 22916882 22917029 148 - 0.909 0.507 -1.681
ENSG00000273749 E030 6.5193221 0.0687329258 7.972395e-02 1.591279e-01 15 22917030 22917313 284 - 1.019 0.707 -1.207
ENSG00000273749 E031 2.1444402 0.0115113631 1.261934e-01 2.288537e-01 15 22917623 22917787 165 - 0.607 0.353 -1.278
ENSG00000273749 E032 194.0424993 0.0003530447 5.559230e-01 6.847003e-01 15 22917788 22917935 148 - 2.292 2.285 -0.026
ENSG00000273749 E033 208.1533009 0.0002347010 7.711455e-01 8.522573e-01 15 22918692 22918858 167 - 2.311 2.326 0.052
ENSG00000273749 E034 156.1265626 0.0005980422 5.784087e-01 7.035007e-01 15 22925982 22926107 126 - 2.202 2.194 -0.026
ENSG00000273749 E035 140.7238218 0.0002459847 4.245770e-02 9.554760e-02 15 22927906 22928028 123 - 2.181 2.129 -0.174
ENSG00000273749 E036 166.9662543 0.0002972723 9.330749e-03 2.711045e-02 15 22932223 22932340 118 - 2.262 2.199 -0.212
ENSG00000273749 E037 173.1267407 0.0002307048 6.253502e-05 3.438818e-04 15 22933802 22933893 92 - 2.295 2.195 -0.334
ENSG00000273749 E038 178.8337550 0.0002372864 2.471257e-04 1.163305e-03 15 22937104 22937208 105 - 2.304 2.214 -0.298
ENSG00000273749 E039 191.4964705 0.0053592056 7.995386e-02 1.594904e-01 15 22939192 22939320 129 - 2.319 2.252 -0.225
ENSG00000273749 E040 201.7995048 0.0038654519 3.203891e-03 1.086743e-02 15 22939411 22939507 97 - 2.362 2.255 -0.359
ENSG00000273749 E041 171.7476514 0.0040533769 1.734831e-03 6.392766e-03 15 22943173 22943228 56 - 2.299 2.179 -0.401
ENSG00000273749 E042 142.2306921 0.0028283148 1.261321e-04 6.418823e-04 15 22943229 22943258 30 - 2.228 2.086 -0.477
ENSG00000273749 E043 128.9709926 0.0013076769 4.047821e-03 1.327484e-02 15 22943259 22943288 30 - 2.162 2.070 -0.311
ENSG00000273749 E044 161.6505768 0.0006912988 3.884301e-06 2.833754e-05 15 22943289 22943354 66 - 2.279 2.150 -0.434
ENSG00000273749 E045 127.6506941 0.0009216793 2.482787e-08 2.841862e-07 15 22944558 22944596 39 - 2.201 2.020 -0.608
ENSG00000273749 E046 151.3450471 0.0033183233 4.961438e-05 2.798242e-04 15 22944597 22944659 63 - 2.261 2.105 -0.519
ENSG00000273749 E047 138.8497181 0.0080744700 1.821309e-04 8.870650e-04 15 22944862 22944939 78 - 2.240 2.050 -0.635
ENSG00000273749 E048 0.8116123 0.1554766736 6.160803e-01 7.342082e-01 15 22946709 22946840 132 - 0.304 0.212 -0.692
ENSG00000273749 E049 0.5085815 0.2292754153 6.736969e-01 7.793163e-01 15 22946841 22947002 162 - 0.126 0.212 0.899
ENSG00000273749 E050 134.0543472 0.0030310372 7.482302e-07 6.386284e-06 15 22947003 22947092 90 - 2.227 2.036 -0.639
ENSG00000273749 E051 106.1919472 0.0038678710 5.797996e-05 3.215306e-04 15 22947169 22947291 123 - 2.119 1.945 -0.583
ENSG00000273749 E052 4.8419977 0.1228882937 4.225836e-01 5.657156e-01 15 22947292 22947318 27 - 0.850 0.697 -0.613
ENSG00000273749 E053 0.4460135 0.0300548684 7.270460e-02 1.478480e-01 15 22947911 22948029 119 - 0.304 0.000 -11.801
ENSG00000273749 E054 54.2633882 0.0004389438 5.334533e-02 1.151025e-01 15 22980287 22980388 102 - 1.787 1.703 -0.282
ENSG00000273749 E055 0.4783925 0.0212151365 5.157147e-01 6.503402e-01 15 22980568 22980630 63 - 0.224 0.118 -1.110
ENSG00000273749 E056 0.2955422 0.0292054044 9.448959e-01   15 22981009 22981063 55 - 0.126 0.118 -0.113