ENSG00000273247

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000608661 ENSG00000273247 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB33B-AS1 lncRNA lncRNA 0.8742443 0.5055151 0.9495218 0.06425247 0.07399242 0.8963008 0.32184021 0.12295791 0.56848767 0.04826878 0.04912571 2.1213166 0.36727083 0.2280000 0.60033333 0.37233333 0.005895862 0.001722269 TRUE FALSE
ENST00000608663 ENSG00000273247 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB33B-AS1 lncRNA lncRNA 0.8742443 0.5055151 0.9495218 0.06425247 0.07399242 0.8963008 0.01005130 0.00000000 0.08041044 0.00000000 0.08041044 3.1764893 0.01052917 0.0000000 0.08423333 0.08423333 0.896611796 0.001722269   FALSE
ENST00000609359 ENSG00000273247 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB33B-AS1 lncRNA lncRNA 0.8742443 0.5055151 0.9495218 0.06425247 0.07399242 0.8963008 0.08573401 0.00000000 0.03469416 0.00000000 0.03469416 2.1600865 0.07437917 0.0000000 0.03226667 0.03226667 0.883517479 0.001722269   FALSE
ENST00000610159 ENSG00000273247 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB33B-AS1 lncRNA lncRNA 0.8742443 0.5055151 0.9495218 0.06425247 0.07399242 0.8963008 0.05497549 0.04798847 0.04276791 0.02058083 0.01473727 -0.1361052 0.07197917 0.0967000 0.04473333 -0.05196667 0.521781533 0.001722269   FALSE
ENST00000685735 ENSG00000273247 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB33B-AS1 lncRNA lncRNA 0.8742443 0.5055151 0.9495218 0.06425247 0.07399242 0.8963008 0.24240274 0.32606338 0.20860954 0.02797136 0.03940669 -0.6203770 0.34741250 0.6575667 0.22066667 -0.43690000 0.001722269 0.001722269   FALSE
MSTRG.25497.5 ENSG00000273247 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB33B-AS1 lncRNA   0.8742443 0.5055151 0.9495218 0.06425247 0.07399242 0.8963008 0.09719058 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.05826667 0.0000000 0.00000000 0.00000000   0.001722269   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000273247 E001 18.9211281 0.001376746 4.759729e-10 7.478159e-09 4 139411927 139413801 1875 - 1.443 0.998 -1.579
ENSG00000273247 E002 1.4468057 0.011151929 2.325815e-01 3.655221e-01 4 139413802 139413815 14 - 0.464 0.250 -1.294
ENSG00000273247 E003 0.9684132 0.014361012 1.995236e-01 3.256358e-01 4 139413816 139413823 8 - 0.373 0.143 -1.809
ENSG00000273247 E004 1.8372593 0.036378616 1.372167e-02 3.758988e-02 4 139413824 139413953 130 - 0.602 0.143 -2.943
ENSG00000273247 E005 1.0987104 0.136154317 1.692350e-01 2.871936e-01 4 139413954 139414024 71 - 0.420 0.144 -2.056
ENSG00000273247 E006 0.2903454 0.391230534 4.220242e-01   4 139415937 139416012 76 - 0.188 0.000 -9.840
ENSG00000273247 E007 0.0000000       4 139416013 139416146 134 -      
ENSG00000273247 E008 0.1451727 0.045122686 6.768400e-01   4 139419870 139419923 54 - 0.105 0.000 -8.845
ENSG00000273247 E009 3.2199666 0.024441170 4.092282e-03 1.340116e-02 4 139448443 139451674 3232 - 0.373 0.831 2.083
ENSG00000273247 E010 5.7417592 0.024109037 2.101710e-02 5.362677e-02 4 139451675 139452356 682 - 0.658 0.962 1.203
ENSG00000273247 E011 2.2153532 0.087888883 5.507271e-01 6.803271e-01 4 139452357 139452497 141 - 0.464 0.568 0.496
ENSG00000273247 E012 3.8719377 0.004442048 7.067965e-01 8.048790e-01 4 139452498 139452931 434 - 0.707 0.653 -0.225
ENSG00000273247 E013 11.1240424 0.002384679 7.532745e-08 7.834079e-07 4 139452932 139453684 753 - 0.791 1.285 1.818
ENSG00000273247 E014 5.1209132 0.003714897 2.309018e-01 3.635550e-01 4 139453685 139454034 350 - 0.707 0.858 0.605