ENSG00000272886

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000294241 ENSG00000272886 HEK293_OSMI2_2hA HEK293_TMG_2hB DCP1A protein_coding protein_coding 15.93246 9.196543 22.91549 1.411378 0.1175936 1.316221 1.168083 0.007475707 3.114334 0.007475707 1.0971535 7.482054 0.05345833 0.0006333333 0.1358333 0.1352000 3.679988e-07 3.679988e-07 FALSE TRUE
ENST00000610213 ENSG00000272886 HEK293_OSMI2_2hA HEK293_TMG_2hB DCP1A protein_coding protein_coding 15.93246 9.196543 22.91549 1.411378 0.1175936 1.316221 13.757425 9.104204429 18.330248 1.417501179 0.7332454 1.008825 0.89197083 0.9897666667 0.7999333 -0.1898333 4.832616e-04 3.679988e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000272886 E001 1496.1390601 0.0099237271 3.442702e-16 1.382972e-14 3 53283429 53287365 3937 - 2.979 3.372 1.307
ENSG00000272886 E002 25.0066624 0.0108959029 8.993070e-03 2.626305e-02 3 53287366 53287369 4 - 1.377 1.328 -0.169
ENSG00000272886 E003 160.4960189 0.0002364032 4.669816e-07 4.155976e-06 3 53287370 53287660 291 - 2.143 2.198 0.184
ENSG00000272886 E004 132.0577575 0.0046478937 1.741881e-03 6.414130e-03 3 53288065 53288283 219 - 2.057 2.114 0.189
ENSG00000272886 E005 1.6931438 0.0091943411 2.989322e-01 4.404128e-01 3 53288284 53288361 78 - 0.414 0.342 -0.412
ENSG00000272886 E006 66.1923974 0.0046462585 8.521973e-05 4.526995e-04 3 53290791 53290856 66 - 1.783 1.752 -0.102
ENSG00000272886 E007 244.7264085 0.0002488304 3.389392e-27 4.462198e-25 3 53292069 53292632 564 - 2.355 2.285 -0.233
ENSG00000272886 E008 127.7941867 0.0053493369 3.078958e-08 3.456384e-07 3 53292633 53292827 195 - 2.077 1.999 -0.261
ENSG00000272886 E009 69.7856629 0.0075718712 7.511946e-04 3.083474e-03 3 53304177 53304220 44 - 1.801 1.784 -0.060
ENSG00000272886 E010 66.1995963 0.0205556960 2.630112e-02 6.455237e-02 3 53304221 53304256 36 - 1.772 1.776 0.012
ENSG00000272886 E011 60.6027158 0.0006774247 9.778223e-06 6.516992e-05 3 53304257 53304290 34 - 1.742 1.720 -0.074
ENSG00000272886 E012 97.0411676 0.0003286431 1.513003e-08 1.804090e-07 3 53312241 53312379 139 - 1.945 1.925 -0.067
ENSG00000272886 E013 57.6707786 0.0004324210 4.204692e-07 3.776628e-06 3 53319407 53319473 67 - 1.732 1.673 -0.200
ENSG00000272886 E014 0.8899506 0.0136488150 6.362529e-02 1.327360e-01 3 53338091 53338145 55 - 0.314 0.001 -9.330
ENSG00000272886 E015 85.5994511 0.0030744520 2.596882e-08 2.961900e-07 3 53342144 53342271 128 - 1.905 1.824 -0.271
ENSG00000272886 E016 64.4403482 0.0008084525 1.390779e-06 1.119537e-05 3 53344902 53344936 35 - 1.772 1.734 -0.129
ENSG00000272886 E017 44.9669611 0.0005196047 1.785637e-05 1.120070e-04 3 53344937 53344942 6 - 1.622 1.574 -0.164
ENSG00000272886 E018 65.5318561 0.0009988612 8.149753e-09 1.021534e-07 3 53347383 53347421 39 - 1.794 1.704 -0.303
ENSG00000272886 E019 78.5996238 0.0026882720 6.490948e-11 1.181032e-09 3 53347422 53347586 165 - 1.882 1.743 -0.469